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1High mobility group box protein 1 and white matter injury following traumatic brain injury: perspectives on mechanisms and therapeutic strategies显示文摘Traumatic brain injury(TBI)is a major cause of morbidity and mortality worldwide.Despite significant medical advances over recent decades,many survivors of TBI develop long term neuro-cognitive deficits.Previously,only moderate and severe injuries were thought to account for the devastating consequences of TBI.However,there is increasing evidence that even milder injuries may result in problematic lifelong cognitive and affective disturbances.TBI is typically characterized by an an acute physical injury followed by a protracted innate neuro-inflammatory response.These reponses,mediated via neuronal,astrocyte and microglial cells,amongst others,and may result in widespread neuronal death and a micro-environment that is not conducive to brain repair(Manivannan et al.,2021).Whilst the primary physical injury often evades intervention from a medical perspective,the subsequent neuro-inflammatory response offers a potential therapeutic target.Nonetheless,effective pharmacological strategies continue to elude clinicians and scientists due to the complex underlying pathogenesis and difficulties of modelling such a heterogeneous disease.However,the majority of research to date has focused on investigating the effects of post-traumatic neuro-inflammation on grey matter injury rather than the consequences upon white matter(WM),which contributes greatly to cognitive dysfunction across many neurological diseases(Filly and Kelly,2018).Herein,we will briefly discuss:(i)high mobility group box protein 1(HMGB1)as a potential therapeutic target;(ii)the relevance of WM injury in TBI and current understanding of WM repair following injury;and(iii)perspectives on how HMGB1 may play a role.Ronak Ved Susruta Manivannan Imogen Tasker Malik Zaben 2022Neural Regeneration Research2022,17,8:2
2Development and characterization of a wood adhesive using bagasse lignin 显示文摘Mozaffar Alam Khan Sayed Marghoob Ashraf Ved Prakash Malhotra 2004International Journal of Adhesion and Adhesives2004,24,6:1
3The pharmocokinetics of propofol in children using three different analysis approaches显示文摘KATARIA R K VED S A NICODERNUS H F 1994Anesthesioloogy1994,80,1:1
4Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate 显示文摘Ved H Koenig M L Dave J R 1997Neuro Report1997,8,4:1
5Neonatal Hypoglycemia显示文摘Ved Bhushan Arya Senthil Senniappan Maria Guemes Khalid Hussain 2014The Indian Journal of Pediatrics2014,,1:1
6Laparoscopic Approach to Pheochromocytoma: Is a Lower Intraabdominal Pressure Helpful?显示文摘Jayashree Sood Lakshmi Jayaraman Ved P. Kumra Pradeep K. Chowbey 2006Anesthesia & Analgesia2006,,2:1
7Mechnaism of magnesium oxychloride formation during the hardening o{ magnesium oxychloride cement 显示文摘Ved E Zharov E F Phong H 1976Zh Prikl Khim (Rus)1976,49,10:1
8Evaluation of vildagliptin and fixed dose combination of vildagliptin and metformin on glycemic control and insulin dose over 3 months in patients with type 2 diabetes mellitus 显示文摘Ved P Shah S 2012Indian J Endocrinol Metab2012,16,1:1
9A dynamic ID-based remote user authentication scheme显示文摘Manik Lal Das Ashutosh Aaxena Ved P Gulati 2004IEEE Transactions on Consumer Electronics2004,50,2:1
10The pharmacokinetics of propofol in children using three different data analysis approaches显示文摘Kataria BK Ved SA Nicodemus HF 1994Anesthesiology1994,80,1:1
11Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration 显示文摘Hulse RP Beazley-Long N Ved N 2015Clin Sci (Lond)2015,129,8:1
12HuperzineA, a ptential therapeutic agent for dementia, reduces neuronalcell death caused by glutamate显示文摘Ved HS Koenig ML Dave JR 1997Neuroreport1997,8,:1
13A novel remote user authentication scheme using bilinear pairings显示文摘Manik Lal Das Ashutosh Saxena A Ved P Gulati 2006Computers & Security2006,,25:1
14Acquired Epidermoid Cysts of the Cauda Equina显示文摘Nica DA Strambu VED Rosca T 2011Journal of Medicine and Life2011,4,3:1
15A dynamic ID-based remote user authentication scheme 显示文摘Manik L D Ashutosh S Ved P G 2004IEEE Transac- tions on Consumer Electronics2004,50,2:1
16The effects of repeated minimal electroconvulsive shock exposure on levels of mRNA encoding fibroblast growth factor-2 and nerve growth factor in limbic regions显示文摘 Ved R Gale K 2002Neuroscience2002,114,2:1
17Development and characterization of a wood adhesive using bagasse lignin 显示文摘Mozaffar Alam Khan Seyed Marghoob Ashraf Ved Prakash Malhotra 2004International Journal of Adhesion and Adhesives2004,24,6:1
18Synthesis,chiral chromatographic separation, and biological activities ofthe enantiomers of 10, 10-dimethylhuperzine A 显示文摘Rajendran V Prakash K R C Ved H S 2000Bioorg Med Chem Lett2000,10,:1
19The 'good governance' concept revisited显示文摘Ved P.Nanda 0,,603:1
20Mechanism of magnesiumoxychloride formation during the hardening of magnesium oxychloridecement显示文摘VED E I ZHAROV E F PHONG H V 1976Zh Prikl Khim1976,49,21:1
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