|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT3 and 5-HT4 receptors in cultured murine small intestine interstitial cells of Cajal显示文摘AIM To investigate the effects of a water extract of Hwangryunhaedok-tang(HHTE) on the pacemaker potentials of mouse interstitial cells of Cajal(ICCs).METHODS We dissociated ICCs from small intestines and cultured. ICCs were immunologically identified using an antic-kit antibody. We used the whole-cell patch-clamp configuration to record the pacemaker potentials generated by cultured ICCs under the current clamp mode(I = 0). All experiments were performed at 30 ℃-32 ℃RESULTS HHTE dose-dependently depolarized ICC pacemaker potentials. Pretreatment with a 5-HT_3 receptor anta-gonist(Y25130) or a 5-HT_4 receptor antagonist(RS39604) blocked HHTE-induced pacemaker potential depolarizations, whereas pretreatment with a 5-HT7 receptor antagonist(SB269970) did not. Intracellular GDPβS inhibited HHTE-induced pacemaker potential depolarization and pretreatment with a Ca^(2+)-free solution or thapsigargin abolished the pacemaker potentials. In the presence of a Ca^(2+)-free solution or thapsigargin, HHTE did not depolarize ICC pacemaker potentials. In addition, HHTE-induced pacemaker potential depolarization was unaffected by a PKC inhibitor(calphostin C) or a Rho kinase inhibitor(Y27632). Of the four ingredients of HHT, Coptidis Rhizoma and Gardeniae Fructus more effectively inhibited pacemaker potential depolarization.CONCLUSION These results suggest that HHTE dose-dependently depolarizes ICC pacemaker potentials through 5-HT_3 and 5-HT_4 receptors via external and internal Ca^(2+) regulation and via G protein-, PKC-and Rho kinase-independent pathways. | Hyun Jung Kim Guem San Lee Hyungwoo Kim Byung Joo Kim | 2017 | World Journal of Gastroenterology2017，23，29： | 3 |
| 2 | Embedded self-sensing piezoelectric for damage detection显示文摘 | Pardo D V C Guemes J A | 1998 | J of Intelligent Material Systems and Structures1998，9，11： | 1 |
| 3 | Effect of route of administration on the pharmacokinetic behavior of enantiomers of nefopam and desmethylnefopam显示文摘 | Chawla J Le - Guem ME Alquier C | 2003 | Ther Drug Monit2003，25，2： | 1 |
| 4 | Predictive models for available chlorine depletion and total microbial count reon during washing of fresh-cut spinach显示文摘 | PIROVANI M GUEMES D PIAGNETINI A | 2001 | Journal of Food Science2001，66，6： | 1 |
| 5 | Oligoguluronates elicit an oxidative burst in the brown algal kelp Laminaria digitata显示文摘 | Kiipper F C Kloareg B Guem J | 2001 | Plant Physiology2001，125，1： | 1 |
| 6 | Neonatal hypoglycemia显示文摘 | Arya VB Senniappan S Guemes M | | 0，，01： | 1 |
| 7 | Neonatal Hypoglycemia显示文摘 | Ved Bhushan Arya Senthil Senniappan Maria Guemes Khalid Hussain | 2014 | The Indian Journal of Pediatrics2014，，1： | 1 |
| 8 | Neonatal hypoglycemia显示文摘 | Arya VB Senniappan S Guemes M | 2014 | Indian J Pediatr2014，81，1： | 1 |
| 9 | Method for calculating the ground resistance of grounding grids vsing FEM显示文摘 | | 2004 | IEEE Transactions on Power Delivery2004，19，2： | 1 |
| 10 | Phosphorylation regulates the water channel activity of the seed-specific aquaporin γ-TIP显示文摘 | Maurel C Kado R T Guem J | 1995 | The EMBO J1995，14，13： | 1 |
| 11 | Effect of graded anterior transposition of the inferior oblique muscle on versions and vertical deviation in primary position显示文摘 | Guemes A Wright KW | 1998 | J AAPOS1998，2，4： | 1 |
| 12 | Binocular function and patient satisfaction after monovision induced by myopic photorefractive keratectomy 显示文摘 | Wright KW Guemes A Kapadia MS Wilson SE | 1999 | J Cataract Refract Surg1999，25，2： | 1 |
| 13 | Modeling changes of sensory attributes for individual and mixed fresh-cut leafy vegetables显示文摘 | PIAGENTINI A M MENDEZ J C GUEMES D R | 2005 | Postharvest Biology & Technology2005，38，3： | 1 |
| 14 | Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice显示文摘AIM To investigate the effects of Hwangryunhaedok-tang(HHT) on gastrointestinal(GI) motility in mice.METHODS The effects of a boiling water extract of HHT(HHTE) on GI motility were investigated by calculating percent intestinal transit rates(ITR%) and gastric emptying(GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction(GMD). In addition, the effects of the four components of HHT, that is, Gardeniae Fructus(GF), Scutellariae Radix(SR), Coptidis Rhizoma(CR), and Phellodendri Cortex(PC), on GI motility were also investigated.RESULTS In normal ICR mice, ITR% and GE values were significantly and dose-dependently increased by the intragastric administration of HHTE(0.1-1 g/kg). The ITR% values of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose-dependently inhibited by HHTE(0.1-1 g/kg). Additionally, GF, CR, and PC dosedependently increased ITR% and GE values in normal and GMD mice.CONCLUSION These results suggest that HHT is a novel candidate for the development of a gastroprokinetic agent for the GI tract. | Hyoyeon Kim Iksung Kim Min Cheol Lee Hyun Jung Kim Guem San Lee Hyungwoo Kim Byung Joo Kim | 2017 | World Journal of Gastroenterology2017，23，15： | 1 |
| 15 | Neonatal hypoglycemia显示文摘 | Arya VB Senniappan S Guemes M | | 0，，01： | 1 |
| 16 | Binocular function and patient satisfaction after monovision induced by myopic photorefractive keratectomy显示文摘 | Wright KW Guemes A Kapadia MS | 1999 | J Cataract Refract Surg1999，25，2： | 1 |
| 17 | Effect of Substrate on the Phase Transformation of TiO2 in Pearlescent Pigment显示文摘 | Young C R Tae G K Guem S S | 2008 | Journal of Industrial and Engineering Chemistry2008，14，： | 1 |
| 18 | Role of calcium ions in the mechanism of action of a lignosulphonate used to modify the wettability of plastics for their separation by flotation显示文摘 | Conil P Houot R | 2000 | Minerals Engineering2000，，1： | 1 |
| 19 | Binocular fu-nction and patient satisfaction after monovision induced by myopic photorefractive keratectomy 显示文摘 | Wright KW Guemes A Kapadia MS Wilson SE | 1999 | J Cataract Refract Surg1999，25，2： | 1 |
| 20 | A practical approach for deternining the ground resistance of grounding grids 显示文摘 | GUEMES J A | 2006 | IEEE Transac- tions on Power Delivery2006，21，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员