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| 1 | Challenges in diagnosing mesenteric ischemia显示文摘Early identification of acute mesenteric ischemia (AMI) is challenging. The wide variability in clinical presentation challenges providers to make an early accurate diagnosis. Despite major diagnostic and treatment advances over the past decades, mortality remains high. Arterial embolus and superior mesenteric artery thrombosis are common causes of AMI. Non-occlusive causes are less common, but vasculitis may be important, especially in younger people. Because of the unclear clinical presentation and non-specific laboratory findings, low clinical suspicion may lead to loss of valuable time. During this diagnostic delay, progression of ischemia to transmural bowel infarction with peritonitis and septicemia may further worsen patient outcomes. Several diagnostic modalities are used to assess possible AMI. Multi-detector row computed tomographic angiography is the current gold standard. Although computed tomographic angiography leads to an accurate diagnosis in many cases, early detection is a persistent problem. Because early diagnosis is vital to commence treatment, new diagnostic strategies are needed. A non-invasive simple biochemical test would be ideal to increase clinical suspicion of AMI and would improve patient selection for radiographic evaluation. Thus, AMI could be diagnosed earlier with follow-up computed tomographic angiography or high spatial magnetic resonance imaging. Experimental in vitro and in vivo studies show promise for alpha glutathione S transferase and intestinal fatty acid binding protein as markers for AMI. Future research must confirm the clinical utility of these biochemical markers in the diagnosis of mesenteric ischemia. | Teun C van den Heijkant Bart AC Aerts Joep A Teijink Wim A Buurman Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，9： | 31 |
| 2 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 3 | Challenges in diagnosing adhesive small bowel obstruction显示文摘Adhesive small bowel obstruction(ASBO)is the most frequently encountered surgical disorder of the small intestine.Up to 80%of ASBO cases resolve spontaneously and do not require invasive treatment.It is important to identify such patients that will benefit from conservative treatment in order to prevent unnecessarily exposing them to the risks associated with surgical intervention,such as morbidity and further adhesion formation.For the remaining ASBO patients,timely surgical intervention is necessary to prevent small bowel strangulation,which may cause intestinal ischemia and bowel necrosis.While early identification of these patients is key to decreasing ASBO-related morbidity and mortality,the non-specific signs and laboratory findings upon clinic presentation limit timely diagnosis and implementation of appropriate clinical management.Combining the clinical presentation findings with those from other diagnostic imaging modalities,such as abdominal X-ray,computed tomography-scan and water-soluble contrast studies,will improve diagnosis of ASBO and help clinicians to better evaluate the potential of conservative management as a safe strategy for a particular patient.Nonetheless,patients who present with moderate findings by all these approaches continue to represent a challenge.A new diagnostic strategy is urgently needed to further improve our ability to identify early signs of strangulated bowel,and this diagnostic modality should be able to indicate when surgical management is required.A number of potential serum markers have been proposed for this purpose,including intestinal fatty acid binding protein andα-glutathione S transferase.On-going research is attempting to clearly define their diagnostic utility and to optimize their potential role in determining which patients should be managed surgically. | Thijs R van Oudheusden Bart AC Aerts Ignace HJT de Hingh Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，43： | 7 |
| 4 | Essential fatty acid status in neonates after fish-oil supplementation during late pregnancy显示文摘 | Van Houwelingen AC S φrensen JD Hornstra G | 1995 | Brit J Nutr1995，74，： | 2 |
| 5 | Dose-finding study of daily GnRH antagonist for the prevention of premature Lid surges in IVF/ICSI patients:optimal changes in LH and progesterone for clinical pregnancy显示文摘 | Huime JA van Loonen AC Schats R | 2005 | Hum Reprod2005，20，2： | 1 |
| 6 | The tolerance of rat spinal cord to interstitial irradiation显示文摘 | Van der plas M Ruifork AC | 1998 | Int J Radiat Oncol Biol Phys1998，40，： | 1 |
| 7 | Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy:European organization for research and treatment of cancer 10801 trial显示文摘 | van Dougen JA Voogd AC Fentiman IS | 2000 | J Natl Cancer Inst2000，92，14： | 1 |
| 8 | The determination of gemcitabine and 2'-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry 显示文摘 | Honeywell R Laan AC van Groeningen C J | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，847，2： | 1 |
| 9 | The site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology显示文摘 | Van der Wal AC Becker AE van der Loos CM | 1994 | Circulation1994，89，： | 1 |
| 10 | The canine 'groove' model,compared with the ACLT model of osteoarthritis显示文摘 | Marijnissen AC van Roermund PM TeKoppele JM | 2002 | Osteoarthritis Cartilage2002，10，2： | 1 |
| 11 | Cluster structure of anaerobic aggregates of an expanded granular sludge bed reactor显示文摘 | Gonzalez-Gil G Lens P van Aelst AC | 2001 | Appl Environ Microbiol2001，67，8： | 1 |
| 12 | Abdominal wall endometriosis: clinical presentation and imaging features with emphasis on sonography显示文摘 | Hensen JH Van Breda Vriesman AC Puylaert JB | 2006 | AJR Am J Roentgenol2006，186，3： | 1 |
| 13 | Perspectives and vision for strain selection in bioaugmentation 显示文摘 | Singer AC van der Gast C J Thompson IP | 2005 | Trends in Biotechnology2005，23，2： | 1 |
| 14 | Treanment of rupu- tures of the lateral ankle ligaments:a meta-analysis 显示文摘 | Pijnenburg AC Van Dijk CN Bossuyt PM | 2000 | J Bone Joint Surs(Am)2000，82，6： | 1 |
| 15 | D-4F,an apoA-I mimetic peptide inhibits the inflammatory response induced by influenza A infection of human type Ⅱ pneumocytes显示文摘 | Van Lenten BJ Wagner AC Navab M | | 0，，20： | 1 |
| 16 | Pathophysiology and clinical significance of the abdominal compartment syndrome显示文摘 | Grubben AC van Baardwijk AA Broering DC | 2001 | Zentralblatt für Chirurgie2001，，08： | 1 |
| 17 | Reliability and validity of the visual analogue scale for fear of falling in older persons显示文摘 | Scheffer AC Schurmans MJ van Dijk N | | 0，，11： | 1 |
| 18 | Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2-and 3-dimensional transesophageal echocardiography and multislice computed tomography显示文摘 | Ng AC Delgado V Van der Kley F | | 0，，01： | 1 |
| 19 | The speed of blood pressure fluctuations in patients with chronic obstructive pulmonary disease显示文摘 | van Gestel AJ Clarenbach CF Stowhas AC | 2014 | Heart Lung Circ2014，23，3： | 1 |
| 20 | Guided bone regeneration in rat mandibular defects using resorbable poly( tri- methylene carbonate ) barrier membranes 显示文摘 | van Leeuwen AC Huddleston Slater JJ Gielkens PF | 2012 | Acta Biomaterialia2012，8，4： | 1 |
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