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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Risk of relapse of childhood acute lymphoblastic leukemia is predicted by flow cytometric measurement of residual disease on day 15 bone marrow显示文摘 | Basso G Veltroni M Valsecchi MG | | 0，，31： | 1 |
| 4 | Improved outcome in high-risk childhood acute lymphoblastic leukemia defined by prednisone-poor response treated with double Berlin-Frankfurt-Muenster protocol 2显示文摘 | Arico M Valsecchi MG Conter V | 2002 | Blood2002，100，2： | 1 |
| 5 | Visual oddbal s induce prolonged microsaccadic inhibition显示文摘 | Valsecchi M Betta E Turatto M | | 0，，02： | 1 |
| 6 | Outcome of treatment in childhood with Philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘 | Arico M Valsecchi MG Camitta B | 2000 | N Engl J Med2000，342，14： | 1 |
| 7 | Improved outcome in high-risk childhood acute lymphoblastic leukemia defined by prednisone poor response treated with double Berlin-Frankfurt- Muenster protocol Ⅱ显示文摘 | Arico M Valsecchi MG Conter V | 2002 | Blood2002，100，2： | 1 |
| 8 | In-hospital clini eal outcome in elderly patients with acute myocardial infarction treated with primary angioplasty 显示文摘 | Tespili M Guagliumi G Valsecchi O | 2003 | Ital Heart J2003，4，3： | 1 |
| 9 | Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘 | Arico M Valsecchi MG Camitta B | 2000 | N Engl J Med2000，342，14： | 1 |
| 10 | Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘 | Arico M Valsecchi MG Camitta B | 2000 | N Engl J Med2000，342，14： | 1 |
| 11 | Fiber laser cladding with high content of WC - Co based powder 显示文摘 | Valsecchi B P~vitali B Vedani M | 2010 | IntJ Mater Form2010，3，1： | 1 |
| 12 | Recent Treatment Advances and Novel Therapies in Pancreas Cancer: A Review显示文摘 | Matias E. Valsecchi Enrique Díaz-Cantón Máximo Vega Susan J. Littman | 2014 | Journal of Gastrointestinal Cancer2014，，2： | 1 |
| 13 | Dynamic Mechanical and Rheological Behavior of Fluoroelastomer-Organoclay Nanocomposites Obtained from Different Preparation Me- thods显示文摘 | Valsecchi R Vigan6 M Levi M | 2006 | Journal of Polymer Science2006，102，5： | 1 |
| 14 | Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma显示文摘 | Valsecchi M E McDonald M Brody J R | 2012 | Cancer2012，118，14： | 1 |
| 15 | Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Munster-based intensive chemotherapy显示文摘 | Conter V Arico M Valsecchi MG | 1995 | Clin Oncol1995，13，10： | 1 |
| 16 | The speed and accuracy of material recognition in natural imag- es显示文摘 | Wiebel C B Valsecchi M Gegenfurtner K R | 2013 | Attention Perception &Psychophysics2013，75，5： | 1 |
| 17 | Outcome of treatment in children with Philadelphia chromosome-positive ( Ph + ) acute lymphoblastic leukemia显示文摘 | Arico M Valsecchi MG Camitta B | 2000 | N Engl J Med2000，342，： | 1 |
| 18 | Sudden Death andAssociated Factors in a Historical Cohort of ChronicHaemodialysis Patients 显示文摘 | Genovesi S Valsecchi M G Rossi E | 2009 | Nephrol Dial Transplant2009，24，8： | 1 |
| 19 | ttydrophilic - oleuphobic behavior in thin films from flunromodified nanoelays and polystyrene 显示文摘 | TURRI S VALSECCHI R VIGANO M | 2009 | Polymer Bulletin2009，63，2： | 1 |
| 20 | AFLP to assess genetic variation in laboratory gerbils (Meriones unguiculatus ) 显示文摘 | Razzou M Papa R Valsecchi P | 2003 | J Heredity2003，94，6： | 1 |
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