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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Oral ziprasidone in thetreatment of patients with bipolar disorders: a critical review显示文摘 | Sacchetti E Galluzzo A Valsecchi P | 2011 | Expert Rev Clin Pharmacol2011，4，2： | 1 |
| 4 | The soy isoflavone genistein reverses oxidative and inflammatory state, neu- ropathic pain, neurotrophic and vasculature deficits in diabetes mouse model显示文摘 | VALSECCHI A E FRANCHI S PANERAI A E | 2011 | Eur J Phammcol2011，650，23： | 1 |
| 5 | Intravenous neural stem cellsabolish nociceptive hypersensitivity and rigger nerve regenera- tion in experimental neuropathy 显示文摘 | Franchi S Valsecchi AE Borsani E | 2012 | Pain2012，153，： | 1 |
| 6 | Visual oddbal s induce prolonged microsaccadic inhibition显示文摘 | Valsecchi M Betta E Turatto M | | 0，，02： | 1 |
| 7 | Ziprasidone vs Clozapine in schizophrenia patients refractory to multiple antipsychotic treatments:the MOZART study显示文摘 | Sacchetti E Galluzzo A Valsecchi P | 2009 | Schizophr Res2009，113，1： | 1 |
| 8 | Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regenera- tion in experimental neuropathy 显示文摘 | Franchi S Valsecchi AE Borsani E | 2012 | Pain2012，153，： | 1 |
| 9 | Sudden death and associated factors in a historical cohort of chronic haemodialysis patients显示文摘 | Genovesi S Valsecchi MG Rossi E | | 0，，： | 1 |
| 10 | Microsatellite markers for the study of cetacean population显示文摘 | Valsecchi E Amos W | 1996 | Molecular Ecology1996，5，： | 1 |
| 11 | Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma显示文摘 | Valsecchi M E McDonald M Brody J R | 2012 | Cancer2012，118，14： | 1 |
| 12 | Behavioral and physiological responses of guide dogs to a situation of emotional dis- tress显示文摘 | FALLANI G Prato PREVIDE E VALSECCHI P | 2007 | Physiol Behav2007，90，4： | 1 |
| 13 | Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regeneration inexperimental neuropathy 显示文摘 | Franchi S Valsecchi AE Borsani E | 2012 | Pain2012，153，4： | 1 |
| 14 | Sudden Death andAssociated Factors in a Historical Cohort of ChronicHaemodialysis Patients 显示文摘 | Genovesi S Valsecchi M G Rossi E | 2009 | Nephrol Dial Transplant2009，24，8： | 1 |
| 15 | Microsatellite markers for the study of cetacean populations显示文摘 | VALSECCHI E AMOS W | 1996 | Mol Ecol1996，5，1： | 1 |
| 16 | Ziprasidone vs c-lozapine in schizophrenia patients refractory to multiple antip- sychotic treatments the MOZART study 显示文摘 | Sacchetti E Galluzzo A Valsecchi P | 2009 | $chizophr Res2009，110，13： | 1 |
| 17 | Microsatellite markers for the study of cetacean population显示文摘 | Valsecchi E and Amos W | 1996 | Molecular Ecology1996，5，： | 1 |
| 18 | Long-term results of a randomized trial on extended use of high dose L-asparaginase for standard risk childhood acute lymphoblastie leukemia 显示文摘 | Pession A Valsecchi MG Masera G Kamps WA Magyarosy E Rizzari C | 2005 | J Clin Oncol2005，23，28： | 1 |
| 19 | Sudden death and associ- ated factors in a historical cohort of chronic haemodialysis patients 显示文摘 | Genovesi S Valsecchi MG Rossi E | 2009 | Nephrol Dial Transplant2009，24，8： | 1 |
| 20 | Free protein S deficiency is a risk factor for venous thrombosis显示文摘 | Faioni E M Valsecchi C Palla A | 1997 | Thromb Haemost1997，78，5： | 1 |
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