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| 1 | Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications显示文摘Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects. | MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI Nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 2 | Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors显示文摘 | Martyn E. Caplin Marianne Pavel Jaros?aw B. ?wik?a Alexandria T. Phan Markus Raderer Eva Sedlá?ková Guillaume Cadiot Edward M. Wolin Jaume Capdevila Lucy Wall Guido Rindi Alison Langley Séverine Martinez Jo?lle Blumberg Philippe Ruszniewski | 2014 | The New England Journal of Medicine2014，，： | 3 |
| 3 | 富含组织细胞型横纹肌母细胞肿瘤:一种组织学独特的横纹肌母细胞肿瘤显示文摘许多软组织肿瘤不能简单地划分为“良性”或“恶性”。WHO软组织和骨肿瘤分类将几种类型的软组织肿瘤(如脂肪细胞肿瘤中的非典型脂肪瘤性肿瘤和内皮细胞肿瘤中的血管内皮瘤)确定为中间型(交界型)。一些软组织肿瘤(如韧带样型纤维瘤病和含铁血黄素沉着性纤维脂肪瘤性肿瘤)被认为是中度恶性肿瘤,这可能是因为它们具有局部侵袭性生长的能力,也可能因为它们(如血管瘤样纤维组织细胞瘤和骨化性纤维黏液样肿瘤)具有较低但无法预测的远处转移风险。血管球肿瘤和PEComa等肿瘤的分类系统不仅可以预测临床良、恶性肿瘤具有合理的敏感性和特异性,而且还可以将这些肿瘤的少部分划分为恶性潜能不确定型。有选择的软组织肿瘤(如胃肠道间质肿瘤和孤立性纤维性肿瘤),应从风险评估的角度来看待,而非良、恶性。显示骨骼肌分化的肿瘤传统上一分为二为良性横纹肌瘤或完全恶性横纹肌肉瘤(RMS)。 | Martinez A P Fritchie K J Weiss S W 张仁亚 | 2019 | 临床与实验病理学杂志2019，35，11： | 3 |
| 4 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 5 | Prognostic value of epidermal growth factor receptors in gastric cancer: a survival analysis by Weibull model incorporating long-term survivors显示文摘 | Alexandre Andrade Anjos Jácome Durval R. Wohnrath Cristovam Scapulatempo Neto Estela C. Carneseca Sérgio V. Serrano Luciano Souza Viana Jo?o S. Nunes Edson Z. Martinez José Sebasti?o Santos | 2014 | Gastric Cancer2014，，1： | 2 |
| 6 | Antioxidant and free radical scavenging activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia 显示文摘 | PF REZ G R M VARGAS S R MARTINEZ M F J | 2004 | Phytother Res2004，18，5： | 1 |
| 7 | Theory of Acoustic Band Structure of Periodic Elastic Composites显示文摘 | Kushwaha M S Halevi P Martinez G | 1994 | Physical Review B1994，49，4： | 1 |
| 8 | Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K^+ channels 显示文摘 | Poliak S Gollan L Martinez R | 1999 | Neuron1999，24，4： | 1 |
| 9 | Rhinitis as an independent risk factor for adult onset asthma显示文摘 | Guerra S Sharrill DL Martinez FD | 2002 | J Allergy Clin Immunol2002，109，3： | 1 |
| 10 | Renal effects of angiotensin Ⅱ-receptor blocka-ed and angiotensin convertase inhibition in man 显示文摘 | Schmitt F Natov S Martinez F | 1996 | Clin Sci1996，90，3： | 1 |
| 11 | Diagnostics for the developing world:microfluidic paper-based analytical devices显示文摘 | Martinez A W Phillips S T Whitesides G M | 2010 | Anal Chem2010，82，1： | 1 |
| 12 | Abandoned mine sites as a source of contamination by heavy metals:A case study in a semi-arid zone显示文摘 | Navarro M C Perez S C Martinez S M J | 2008 | Journal of Geochemical Exploration2008，96，23： | 1 |
| 13 | Alternative activation of macrophages:mechanism and functions显示文摘 | Gordon S Martinez FO | 2010 | Immunity2010，32，5： | 1 |
| 14 | Sustainable aquacul- ture and producer performance:measurement of envi- ronmentally adjusted productivity and efficiency of a sample of shrimp farms in Mexico显示文摘 | Francisco J Martinez C Ping S L | 2004 | Aquaculture2004，241，14： | 1 |
| 15 | The influence of specific mechanical energy on cornmeal viscosity measured by an on - line systemduring twin - screw extrusion 显示文摘 | Chang Y K Martinez - Bustos F Park T S | 1999 | Brazilian Journal of Chemical Engineering1999，16，3： | 1 |
| 16 | Pulmonary nocardiosis: risk factors, clinical features, diagnosis and prognosis 显示文摘 | Martinez R Reyes S Menendez R | 2008 | Curr Opin Pulm Med2008，14，3： | 1 |
| 17 | Design, synthesis and biological evaluation of new 3--1-arylpropane derivatives as potential antidepressants with a dual mode of action: Serotonin reuptake inhibition and 5-HT1A receptor antagonism 显示文摘 | Oficialdegui A M Martinez J P6rez S | 2000 | II Farmaco2000，55，5： | 1 |
| 18 | Genetic variability and relationship of closely related Spanish traditional cultivars of tomato as detected by SRAP and SSR markers 显示文摘 | Ruiz J J Garcia - Martinez S Pico B | 2005 | J Am Soc Horticult Sci2005，130，1： | 1 |
| 19 | Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate显示文摘 | Elbashir S M Martinez J Patkaniowska A | 2001 | EMBO J2001，20，23： | 1 |
| 20 | Rhinitis as an independent risk factor for adult-onset asthma 显示文摘 | Guerra S Sherrill DL Martinez FD | 2002 | J Allergy Clin Immunol2002，109，3： | 1 |
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