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| 1 | Benefit of combination β-blocker and endoscopic treatment to prevent variceal rebleeding: A meta-analysis显示文摘AIM: To determine whether the association of β-blockers with endoscopic treatment is superior to endoscopic treatment alone for the secondary prophylaxis of oesophageal variceal bleeding. METHODS: Randomised controlled trials comparing sclerotherapy (SCL) with SCL plus β-blockers (BB) or banding ligation (BL) with BL plus BB were identif ied.Main outcomes were overall and 6, 12 and 24 mo rebleeding rates, as well as overall and 6, 12 and 24 mo mortality. Two statistical methods were used: Yusuf-Peto, and Der Simonian and Laird. Inter-trial heterogeneity was systematically taken into account. RESULTS: Seventeen randomised controlled trials were included, 14 with SCL and 3 with BL. Combination β-blocker and endoscopic treatment signif icantly reduced rebleeding rates at 6, 12 and 24 mo and overall [odds ratio (OR): 2.20, 95% conf idence interval (CI): 1.69-2.85, P<0.0001] compared to endoscopic treatment alone. Mortality at 24 mo was signif icantly lower for the combined treatment group (OR: 1.83, 95% CI:1.16-2.90, P= 0.009), as well as overall mortality (OR: 1.43, 95% CI:1.03-1.98, P= 0.03). CONCLUSION: Combination therapy should thus be recommended as the fi rst line treatment for secondary prophylaxis of oesophageal variceal bleeding. | Natalie Funakoshi Frédérique Ségalas-Largey Yohan Duny Frédéric Oberti Jean-Christophe Valats Michael Bismuth Jean-Pierre Daurès Pierre Blanc | 2010 | World Journal of Gastroenterology2010，16，47： | 24 |
| 2 | Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination 显示文摘 | Valats JC Tuaillon E Funakoshi N | 2010 | Vaccine2010，28，： | 1 |
| 3 | Matrix metalloproteinases:the clue to intervertebral disc degeneration显示文摘 | Goupille P Jayson MI Valat JP | 1998 | Spine1998，23，14： | 1 |
| 4 | A new serologic index for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels显示文摘 | Benboubker L Valat C Linassier C | 2000 | Ann Oneol2000，11，11： | 1 |
| 5 | Matrix metalloproteinases: the clue to intervertebral disc degeneration 显示文摘 | Goupille P J ayson MI Valat JP | 1998 | Spine1998，23，： | 1 |
| 6 | Prospects of improved oil recovery related to wetability and brine composition 显示文摘 | Morrow R N Tang G Valat M | 1998 | J Petrol Sci Engng1998，20，： | 1 |
| 7 | A new serologic index for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels显示文摘 | Benboubker L Valat C Linassier C | | 0，，11： | 1 |
| 8 | A new serologic index for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels显示文摘 | Benboubker L Valat C Linassier C | 2000 | Ann Oneol2000，11，： | 1 |
| 9 | A new serologic index for low-grade non-Hodgkin ' s lymphoma based on initial CA125 and LDH serum levels 显示文摘 | Benboubker L Valat C Linassier C | 2000 | Ann Oncol2000，11，11： | 1 |
| 10 | A disposal protein A-Based immunosensor for flow-injection assay with electrochemical detection显示文摘 | VALAT C LIMOGES B HUET D | 2000 | Analytica Chimica Acta2000，404，2： | 1 |
| 11 | Symptomatic efficacy of avocado/ soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month follow-up demonstrating a persistent effect显示文摘 | Maheu E Mazieres B Valat JP | 1998 | Arthritis Rheum1998，41，1： | 1 |
| 12 | A new serologic index for low-grade non-Hodgkin's lym- phoma based on initial CA123 and LDH serum levels显示文摘 | BENBOUBKER L VALAT C LINASSIER C | 2000 | Ann Oncol2000，11，： | 1 |
| 13 | A new serologic index for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels 显示文摘 | Benboubker L Valat C Linassier C | 2000 | Ann Oneol2000，11，1： | 1 |
| 14 | Matrix metalloproteinases:the clue to intervertebral disc degeneration显示文摘 | Goupille P Jayson M I Valat J P | | 0，，14： | 1 |
| 15 | A new serologic index for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels 显示文摘 | Benboubker L Valat L Linassier C | 2000 | Ann Oncol2000，11，11： | 1 |
| 16 | Pathophysiology of gestational diabetes显示文摘 | Vambergue A Valat AS Dufour P | 2002 | J Gynecol Obstet Biol Reprod (Paris)2002，31，6： | 1 |
| 17 | Pathophysiology of gestational diabetes显示文摘 | Vambergue A Valat AS Dufour P | 2002 | J Gynecol Obstet Biol Reprod(Paris)2002，31，6： | 1 |
| 18 | A new serologic indes for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels显示文摘 | Benboubker L Valat C Linassier C | 2000 | Ann Oncol2000，11，： | 1 |
| 19 | Matrix metalloproteinases:the clue to intervertebral disc degeneration?显示文摘 | Goupille P Jayson MI Valat JP | 1998 | Spine1998，23，14： | 1 |
| 20 | Matrix metalloproteinases:The clue to intervertebral disc degeneration显示文摘 | Goupille P Jayson MI Valat JP | 1998 | Spine1998，23，14： | 1 |
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