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| 1 | New means to monitor the effect of glucocorticoid therapy in children显示文摘AIM:To study the individual effects of glucocorticoid (GC) therapy on the state ofimmune activation in patient serum.METHODS:We developed a novel assay in which the effect of corticosteroid-treated patient serum on healthy donor peripheral blood mononuclear cells (target cells) was studied,with a panel of markers for effector [interferon (IFN)γ and interleukin (IL)-5] and regulatory T cells (FOXP3 and glucocorticoid-induced tumor necrosis factor receptor,GITR).The study group comprised 19 children with inflammatory bowel disease.The individual effect of patient serum on target cells was analyzed prior to GC therapy and 2 wk later.RESULTS:The effect of GC therapy mediated by patient serum was seen as a decrease in the target cells expression of regulatory T-cell-related markers GITR (median suppression 24%,range of suppression 1%-63%,in 2 cases increase of 6% and 77%,P < 0.01 for mitogen-activated target cells) and FOXP3 (median suppression 33%,range of suppression 0%-79%,in one case an increase of 173%,P < 0.05 for resting cells),and secretion of IFNγ [from a mean of 87 700 pg/mL (SD 33 900 pg/mL) to 60 900 pg/mL (SD 44 200 pg/mL) in mitogen-activated target cells,13 of the cases showed a decrease,P < 0.01].The total or weight-related prednisolone dose did not correlate with the patient-seruminduced changes in the target cell markers.CONCLUSION:GC response could be monitored at an individual level by studying the effect of patient serum on signaling pathways of target immune cells. | Hanne Rintamki Harri M Salo Outi Vaarala Kaija-Leena Kolho | 2010 | World Journal of Gastroenterology2010，16，9： | 4 |
| 2 | Antibodies to prothrombin imply a risk of myocardial infarction in middle-aged men显示文摘 | Vaarala O Puurunen M Manttari M | 1996 | Thromb Haemost1996，75，3： | 1 |
| 3 | Simvastatin protects a-gainst multiple low-dose streptozotocin-induced type 1 di-abetes in CD-1 mice and recurrence of disease innonobese diabetic mice显示文摘 | Rydgren T Vaarala O Sandler S | 2007 | J Pharmacol Exp Ther2007，323，1： | 1 |
| 4 | Lactose inhibits regulatory T-cell-mediated suppression of effector T-cell interferon-Tand IL- l7 production显示文摘 | Paasela M Kolho KL Vaarala O | 2014 | Br J Nutr2014，112，11： | 1 |
| 5 | Cow's milk formula feeding induces primaryimmunization to insulin in infants at genetic risk for type 1diabetes显示文摘 | Vaarala O Knip M Paronen J | 1999 | Diabetes1999，48，： | 1 |
| 6 | Neurogenic Pulmonary Edema in Patients with Nontraumatic Intracerebral Hemorrhage: Predictors and Association with Outcome显示文摘 | Eija Junttila Tero Ala-Kokko Pasi Ohtonen Anne Vaarala Ari Karttunen Olli Vuolteenaho Tuula Salo Meeri Sutinen Toni Karhu Karl-Heinz Herzig Juha Koskenkari | 2013 | Anesthesia & Analgesia2013，，4： | 1 |
| 7 | Cow milk feeding induces antibodies toinsulin in children--a link between cow milk and insulin-dependent diabetesmellitus?显示文摘 | Vaarala O Paronen J Otonkoski T | 1998 | Scand J Immunol1998，47，： | 1 |
| 8 | Gut mierobiota and type 1 diabetes 显示文摘 | Vaarala O | 2012 | Rev Diabet Stud2012，9，4： | 1 |
| 9 | Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice显示文摘 | Vaarala O Sandler S | 2007 | J Pharmacol Exp Ther2007，323，1： | 1 |
| 10 | Interplay between PT- PN22 C1858T polymorphism and cow' s milk formula exposure in type 1 diabetes显示文摘 | Lempainen J Vaarala O Makela M | 2009 | J Autoimmun2009，33，： | 1 |
| 11 | Infiltration of Foxp3- and Toll-like Receptor-4–positive Cells in the Intestines of Children With Food Allergy显示文摘 | Mia Westerholm-Ormio Outi Vaarala Minna Tiittanen Erkki Savilahti | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，4： | 1 |
| 12 | Induction of interferongamma and IL - 4 production by mitogen and specific antigens in peripheral blood lymphocytes of Type 1 diabetes patients显示文摘 | Halminen M Juhela S Vaarala O | 2001 | Autoimmunity2001，34，1： | 1 |
| 13 | Differentially expressed genes in two LNCaP prostate cancer cell lines reflecting changes during prostate cancer progression 显示文摘 | Vaarala MH Porvari K Kyllonen A | 2000 | Lab Invest2000，80，8： | 1 |
| 14 | Several genes encoding ribosomal proteins are over-expressed in prostate-cancercell lines:confirmation of L7a and L37 over-expression in prostate-cancer tissue samples显示文摘 | Vaarala MH Porvari KS Kyllonen AP | 1998 | Int J Cancer1998，78，1： | 1 |
| 15 | HuR expression is a marker of poor prognosis in renal cell carcinoma显示文摘 | Ronkainen H Vaarala MH Hirvikoski P | 2011 | Tumour Biol2011，32，： | 1 |
| 16 | CIP2A expression is increased in prostate cancer显示文摘 | Vaarala MH Vaisanen MR Ristinaki A | | 0，，01： | 1 |
| 17 | Fecal Microbiota Composition Differs Between Children With [Beta]-Cell Autoimmunity and Those Without显示文摘 | de Goffau Marcus C Luopaj?rvi Kristiina Knip Mikael Ilonen Jorma Ruohtula Terhi H?rk?nen Taina Orivuori Laura Hakala Saara Welling Gjalt W Harmsen Hermie J Vaarala Outi | 2013 | Diabetes2013，，4： | 1 |
| 18 | Crossreaction becveen antibodies to oxidized low-density lipoprotein and to cardiolipin in systemic lipus erythomatosus显示文摘 | Vaarala O Alfthan G Janhiainen M | 1993 | Lancent1993，341，： | 1 |
| 19 | Leaking gut in type 1 diabetes 显示文摘 | Vaarala O Vaarala O | 2008 | Current Opinion in Gastroenterology2008，24，3： | 1 |
| 20 | Retro- spective analysis of long-term outcomes of 64 patients treated by endopyelotomy in two low-volume hospitals: good and durable results显示文摘 | Vaarala M H Marttila T Paananen I | 2008 | J Endourol2008，22，8： | 1 |
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