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| 1 | Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract显示文摘Metabotropic glutamate receptor subtype 5(mGluR5) is a Group I mGlu subfamily of receptors coupled to the inositol trisphosphate/diacylglycerol pathway. Like other m Glu R subtypes, mGluR5 s contain a phylogenetically conserved, extracellular orthosteric binding site and a more variable allosteric binding site, located on the heptahelical transmembrane domain. The mGluR5 receptor has proved to be a key pharmacological target in conditions affecting the central nervous system(CNS) but its presence outside the CNS underscores its potential role in pathologies affecting peripheral organs such as the gastrointestinal(GI) tract and accessory digestive organs such as the tongue, liver and pancreas. Following identification of mGluR5s in the mouth, various studies have subsequently demonstrated its involvement in mechanical allodynia, inflammation, pain and oral cancer. mGluR5 expression has also been identified in gastroesophageal vagal pathways. Indeed, experimental and human studies have demonstrated that mGluR5 blockade reduces transient lower sphincter relaxation and reflux episodes. In the intestine, mGluR5s have been shown to be involved in the control of intestinal inflammation, visceral pain and the epithelial barrier function. In the liver, mGluR5s have a permissive role in the onset of ischemic injury in rat and mice hepatocytes. Conversely, livers from mice treated with selective negative allosteric modulators and mGluR5 knockout mice are protected against ischemic injury. Similar results have been observed in experimental models of free-radical injury and in vivo mouse models of acetaminophen intoxication. Finally, mGluR5s in the pancreas are associated with insulin secretion control. The picture is, however, far from complete as the review attempts to establish in particular as regards identifying specific targets and innovative therapeutic approaches for the treatment of GI disorders. | Andrea Ferrigno Clarissa Berardo Laura G Di Pasqua Veronica Siciliano Plinio Richelmi Mariapia Vairetti | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Screening of virulence- associated genes as a molecular typing method for characteriza- tion of Streptococcus suis isolates recovered from wild boars and pigs显示文摘 | Veronica S R Jose F G Lucas D | 2016 | Vet J2016，209，： | 1 |
| 3 | Degradation of chlorophenols by means of advanced oxidation processes: a general review 显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | Applied Catalysis B: Environmental2004，47，： | 1 |
| 4 | The effect of mode of exercise on fat oxidation during exercise显示文摘 | STEPHEN C G VERONICA J S DEVONNA A | 1999 | J Strength Condition Res1999，13，1： | 1 |
| 5 | Inactivation of HIV in blood显示文摘 | ASA O VERONICA G SAIKA A | 2002 | Transfusion2002，42，10： | 1 |
| 6 | Degradation of chlorophenols by means of advanced oxidation processes: a general review 显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | Applied Catalysis B : Environmental2004，47，4： | 1 |
| 7 | Alignment of carbon nanotubes under low magnetic fields through attachment of magnetic nanoparticles 显示文摘 | Miguela C D Marek G Veronica S M | 2005 | J Phys Chem B2005，109，19： | 1 |
| 8 | Synthetic opals based on silica-coated gold nanoparticles显示文摘 | Florencio G S Veronica S M Cefe L | 2002 | Langmuir2002，18，： | 1 |
| 9 | Aging,metabolic syndrome and the heart显示文摘 | Veronica G Esther RR | 2012 | Aging Dis2012，3，3： | 1 |
| 10 | Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs 显示文摘 | Hirotsugu U Nieves G Veronica S | 2011 | 32(8) :16852011，32，8： | 1 |
| 11 | Appli Cat B: Environ显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | 47(4):219-2562004，47，4： | 1 |
| 12 | Interactions of Acetobacter diazotrophicus with an amylolytie yeast in nitrogen-free batch culture显示文摘 | ENIO H C VERONICA M R ANA C G S JOHANNA D | 1993 | FEMS Microbiol Leters1993，106，： | 1 |
| 13 | Electronic and magnetic properties of iron: dinuclear complexes with carboxylate bridges 显示文摘 | Veronica P G Ramon O L Evgenia S | 2004 | Polyhedron2004，23，11： | 1 |
| 14 | Anovel de novo nonsense mutation in ATP1A2 associated with sporadic hemiplegic migraine and epileptic seizures显示文摘 | Andrea G Alessandra T Veronica C | 2008 | Journal of the Neurological Sciences2008，273，： | 1 |
| 15 | In vivo abnormal keratinization in Darier-White's disease as viewed by real-time confocal imaging显示文摘 | Salvador G Gennady R Veronica M | | 0，，： | 1 |
| 16 | A consistent attentional bias for drug-related material in active cocaine users across word and picture versions of the emotional Stroop task 显示文摘 | Robert H Veronica D Hugh G | 2006 | Drug Alcohol Depend2006，81，： | 1 |
| 17 | Acute cadmium exposure enhances AP-1 DNA binding and induces cytokines expressien and heat shock protein 70 in HepG2 cells显示文摘 | Veronica S Madel C Luis G | 2004 | Toxicology2004，197，： | 1 |
| 18 | Electrodeposition of PbO2 on glassy carbon electrodes: Influence of ultrasound frequency 显示文摘 | VERONICA S JOS G JESJS I | 2004 | Electrochemistry Communications2004，6，8： | 1 |
| 19 | Method for measuring antioxidant activity and its application to monitoring the antioxidant capacity of wines显示文摘 | Fogliano V Veronica V Randazzo G | 1999 | Agric Food Chem1999，47，： | 1 |
| 20 | Peri-urbanization and in-home environmental health risks: the side effects of planned and unplanned growth 显示文摘 | JAY G PATRICK G VERONICA C - B | 2004 | Environmental Health2004，，207： | 1 |
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