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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Progress of mesenchymal stem cell therapy for neural and retinal diseases显示文摘Complex circuitry and limited regenerative power make central nervous system(CNS)disorders the most challenging and difficult for functional repair.With elusive disease mechanisms,traditional surgical and medical interventions merely slow down the progression of the neurodegenerative diseases.However,the number of neurons still diminishes in many patients.Recently,stem cell therapy has been proposed as a viable option.Mesenchymal stem cells(MSCs),a widely-studied human adult stem cell population,have been discovered for more than 20 years.MSCs have been found all over the body and can be conveniently obtained from different accessible tissues:bone marrow,blood,and adipose and dental tissue.MSCs have high proliferative and differentiation abilities,providing an inexhaustible source of neurons and glia for cell replacement therapy.Moreover,MSCs also show neuroprotective effects without any genetic modification or reprogramming.In addition,the extraordinary immunomodulatory properties of MSCs enable autologous and heterologous transplantation.These qualities heighten the clinical applicability of MSCs when dealing with the pathologies of CNS disorders.Here,we summarize the latest progress of MSC experimental research as well as human clinical trials for neural and retinal diseases.This review article will focus on multiple sclerosis,spinal cord injury,autism,glaucoma,retinitis pigmentosa and age-related macular degeneration. | Tsz Kin Ng Veronica R Fortino Daniel Pelaez Herman S Cheung | 2014 | World Journal of Stem Cells2014，6，2： | 13 |
| 3 | Screening of virulence- associated genes as a molecular typing method for characteriza- tion of Streptococcus suis isolates recovered from wild boars and pigs显示文摘 | Veronica S R Jose F G Lucas D | 2016 | Vet J2016，209，： | 1 |
| 4 | Excitotoxic damage,disrupted energy metabolism,and oxidative stress in the rat brain:antioxidant and neuroprotective effects of L-carnitine显示文摘 | DANIELA S A VERONICA P D C MARA N H M | 2008 | Jonrnal of Neurochemistry2008，105，： | 1 |
| 5 | The effect of dietary docosahexaenoic acid (DHA)on growth,survival and pigmentation of California halibut Paralichthys californicus larvae ( Ayres, 1810 ) 显示文摘 | Veronica V O Juan P L a Benjamin B S | 2010 | Aquaculture2010，302，： | 1 |
| 6 | Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellar DNA replication 显示文摘 | Nilma B Veronica S Deborah H | 2003 | J Virol2003，77，4： | 1 |
| 7 | Struc-tural evolution of the Neogene Gar Basin,western Tibet:Implications for releasing bend development and drainagepattems显示文摘 | Veronica I S Michael A M William R D | 2010 | GSA Bulletin2010，122，56： | 1 |
| 8 | Identification and characterization of nine polymorphic microsatellite loci in the North American pika,Ochotona princes显示文摘 | Veronica S Kirchoff and Susan J Merideth | 2002 | Molecukar Ecology Notes2002，11，2： | 1 |
| 9 | Design and validation of an ELISA for equine infectious anemia (EIA) diagnosis using synthetic peptides显示文摘 | Adriana S Veronica V Mario R | 2001 | Vet Microbiol2001，79，： | 1 |
| 10 | The effect of mode of exercise on fat oxidation during exercise显示文摘 | STEPHEN C G VERONICA J S DEVONNA A | 1999 | J Strength Condition Res1999，13，1： | 1 |
| 11 | Activity-related typologies and longitudinal change in physical activity and sedentary time in children and adolescents:The UP&DOWN Study显示文摘Background:Children and adolescents can be distinguished by different typologies(clusters) of physical activity and sedentary behavior.How physical activity and sedentary behaviors change over time within different typologies is not known.This study examined longitudinal changes in physical activity and sedentary time among children and adolescents with different baseline typologies of activity-related behavior.Methods:In this longitudinal study(3 annual time points) of children(n=600,age=9.2±0.4 years(mean±SD),50.3% girls) and adolescents(n=1037,age=13.6±1.7 years,48.4% girls),participants were recruited in Spain in 2011-2012.Latent class analyses identified typologies based on self-reported screen,educational,social and relaxing sedentary behaviors,active travel,muscle strengthening activity,and sport at baseline.Within each typology,linear mixed growth models explored longitudinal changes in accelerometer-derived moderate-to-vigorous physical activity and sedentary time,as well as time by class interactions.Results:Three typologies were identified among children( 'social screenies',12.8%;'exercisers',61.5%;and 'non-sporty active commuters',25.7%) and among adolescents 'active screenies',43.5%;'active academics',35.0%;and 'non-sporty active commuters',21.5%) at baseline.Sedentary time increased within each typology among children and adolescents,with no significant differences between typologies.No changes in physical activity were found in any typology among children.In adolescents,physical activity declined within all typologies,with 'non-sporty active commuters' declining significantly more than 'active screenies' over 3 years.Conclusion:These results support the need for interveation to promote physical activity and prevent increases in sedentary time during childhood and adolescence.Adolescents characterized as 'non-sporty active commuters' may require specific interventions to maintain their physical activity over time. | Kate Parker Anna Timperio Jo Salmon Karen Villanueva Helen Brown Irene Esteban-Cornejo Veronica Cabanas-Sánchez José Castro-Pinero David Sánchez-Oliva OscarL.Veiga | 2021 | Journal of Sport and Health Science2021，10，4： | 1 |
| 12 | Temperature and emulsifier concentration effects on gallic acid distribution in a model food emulsion显示文摘 | SONIA L B VERONICA S P | 2012 | Journal of Colloid and Interface Science2012，，370： | 1 |
| 13 | DNA damage produced by cadmium in a human fetal hepatic cell line显示文摘 | Piedad LO Veronica S Leticia B | 1999 | Mutat Res1999，439，： | 1 |
| 14 | The impact of a 100% smoke- free law on the health of hospitality workers from the city of Neuquen, Argentina显示文摘 | Veronica S Mariela A Ernesto R | 2010 | Tob Control2010，19，： | 1 |
| 15 | Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses显示文摘 | Veronica S Antonio D Antonio L | 2003 | J Clin Invest2003，111，2： | 1 |
| 16 | Human cytomegalovirus infection leads to accumulation of Geminin and inhibition of cellular DNA replication显示文摘 | Nilima B Veronica S Deborah H | 2003 | J Virol2003，77，4： | 1 |
| 17 | Accounting for spatial var-iability in field experim ents on tea Experim ental显示文摘 | PEIRIS T U S SAMITA S VERONICA W H D | 2008 | Agriculture2008，44，4： | 1 |
| 18 | Interactions between isoflavones and soybean proteins : Applications in soybean - proteineisolate production 显示文摘 | Francisco S Veronica M Marfa C | 2010 | LWT - Food Science and Technology2010，32，2010： | 1 |
| 19 | Improvement in mechanical and structural integrity of natural stone by applying un- saturated polyester resin - nanosilica hybrid thin coating显示文摘 | VERONICA M M VERONICA P S JOSE M M | 2008 | Europe- an Polymer Journal2008，44，10： | 1 |
| 20 | A pseudoautoso mal random amplified polymorphic DNA marker for the sex chromosomes of Silene dioica 显示文摘 | Veronica S D Kesseli R V Muleahy D L | 1998 | Genetics1998，149，： | 1 |
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