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	题名	作者	年代	出处	被引量
1	ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease.	Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde	2014	World Journal of Gastroenterology2014，20，10：	2
2	GC-MS analysis of breath odor compounds in liver patients显示文摘	Van den Velde S Nevens F Van Hee P	2008	J Chromatogr B Analyt Technol Biomed Life Sci2008，875，2：	1
3	Cross-national variation in the gender gap in depression 显示文摘	Van de Velde S Bracke P Levecque Gender differences in de- pression in 23 European countries	2010	Soc Sci Med2010，71，2：	1
4	Poly-L-Lysine induces fibrosis on alginate microcapsules via the induction of cytokines显示文摘	STRAND B L RYAN T L INT VELD P	2001	Cell Transplant2001，10，3：	1
5	Neuronspecific enolase as a marker of brain metastasis in patients with small-cell lung carcinoma显示文摘	Van de Pol M Tgwijnstra A Ten Velde G P	1994	J Neurooncol1994，19，2：	1
6	Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treat- ment of Cancer trial 10902 显示文摘	van der HAGE J A van de VELDE C J H JULIEN J P	2001	J Clin Oneol2001，19，22：	1
7	Interactional metadiscourse in research article absrtacts 显示文摘	GILLAERTS P & VAN DE VELDE F	2010	Journal of English for Academic Purpose2010，，9：	1
8	Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘	Bal P M De Lange A H Jansen P G W Der Velde M E G V	2008	Journal of Vocational Behavior2008，72，1：	1
9	Influ- ence of age,comorbidity and performance status on the choice of treatment for patients with non- small cell lung cancer : re- sults of a population- based study 显示文摘	De RIJKE J M SCHOUTEN L J Ten VELDE G P	2004	Lung Cancer2004，46，2：	1
10	The immediate bactericidal effect of lactic acid on meat-borne pathogens显示文摘	VAN NETTEN P J HJ HUIS IN'T VELD	1994	App1Bacteriol1994，，77：	1
11	Cell allocation and chromosomal complement of parthenogenetic and IVF bovine embryos显示文摘	Van De Velde A Liu L Bols P E J	1999	Molecular reproduction and development1999，54，1：	1
12	A ge- nomic and functional inventory of deubiquitinating enzymes显示文摘	NIJMAN S M LUNA-VARGAS M P VELDS A et o/	2005	Cell2005，123，5：	1
13	Toxicity of sediments contaminated with fractions of creosote 显示文摘	Sved D W Roberts M H Van Veld P A	1997	Water Reseach1997，31，2：	1
14	Model for patterned erosion 显示文摘	Slikkerveer P J in 't Veld F H	1999	Wear1999，，：	1
15	Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer显示文摘	van de VELDE H KARASEK P	2004	J Clin Oncol2004，22，8：	1
16	Phase Ⅲ trial of gemeitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer显示文摘	Van Cutsem E van de Velds H Karasek P	2004	J Clin Oncol2004，22，：	1
17	β-cell replication is increased in donor organs from young patients after prolonged life support显示文摘	In't Veld P De Munck N Van Belle K		0，，07：	1
18	Development of PCR-based markers for detection of Leifsonia xyli subsp, xyli in fibrovascular fluid of infected sugarcane plants 显示文摘	TAYLOR P W J PETRASOVITE L A VELDE R	2003	Australasion Plant Pathology2003，32，3：	1
19	Detection of brain metastases from small cell lung cancer: consequences of changing imaging techniques显示文摘	Seute T Leffers P ten Velde GP	2008	Cancer2008，112，：	1
20	Pharse Ⅲtrial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer 显示文摘	Van de velde P Karasek H	2004	J Clin Oncol2004，，：	1

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