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| 1 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 2 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 3 | Antihy- pertensive drugs and incidence of dementia: the Rotter- dam Study 显示文摘 | Bint Veld BYA Ruitenberg A Hofman A | 2001 | Nettrobiol Aging2001，，22： | 1 |
| 4 | Intrathecal sufentanil and fetal heart rate abnormalities:a double-blind,double placebo-controlled trial comparing two forms of combined spinal epidural analgesia with epidural analgesia in labor显示文摘 | VAN DE VELDE M TEUNKENS A HANSSENS M | 2004 | Anesth Analg2004，98，4： | 1 |
| 5 | Inflammatory signal transduction in Crohn's disease and novel therapeutic approaches显示文摘 | Van Montfrans C Peppelenbosch M Te Velde A A | 2002 | Biochem Pharmacol2002，64，： | 1 |
| 6 | Nonsteroidal antiinflammatory drugs and the risk of Alzheimer′s disease显示文摘 | in t′Veld BA Ruitenberg A Hofman A Launer LJ van Duijn CM Stijnen T | 2001 | N Engl J Med2001，345，21： | 1 |
| 7 | Gastric cancer:epidemiology, pathology and treatment显示文摘 | Alberts SR Cervantes A Velde CJ | 2003 | Ann Oncol2003，14，12： | 1 |
| 8 | Efficient gene ration and amplification of high-capacity adeno-associated virus Padenovirus hybrid vectors显示文摘 | Goncalves M A vander Velde I Janssen J M | 2002 | J Virol2002，76，10： | 1 |
| 9 | Neuronspecific enolase as a marker of brain metastasis in patients with small-cell lung carcinoma显示文摘 | Van de Pol M Tgwijnstra A Ten Velde G P | 1994 | J Neurooncol1994，19，2： | 1 |
| 10 | Early endostatin treatment inhibits metastatic seeding of murine colorectal cancer cells in the liver and their adhesion to endothelial cells 显示文摘 | Velde EA Reijerkerk A Brandsma D | 2005 | Br J Cancer2005，92，4： | 1 |
| 11 | Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treat- ment of Cancer trial 10902 显示文摘 | van der HAGE J A van de VELDE C J H JULIEN J P | 2001 | J Clin Oneol2001，19，22： | 1 |
| 12 | Gastric cancer: epidemiology, pathology and treatment 显示文摘 | Alberts SR Cervantes A van de Velde CJ | 2003 | Ann Oncol2003，14，2： | 1 |
| 13 | Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘 | Bal P M De Lange A H Jansen P G W Der Velde M E G V | 2008 | Journal of Vocational Behavior2008，72，1： | 1 |
| 14 | A quantitative review of the effects of biochar application to soils on crop productivity using meta-analysis显示文摘 | Jeffery S Verheijen F G A van der Velde M | 2011 | Agriculture Ecosystems & Environment2011，144，： | 1 |
| 15 | Police Message Diffu- sion on Twitter: Analysing the Reach of Social Media Communi- cations显示文摘 | Van De Velde B Meijer A Homburg V | 2015 | Behaviour & Information Technology2015，34，1： | 1 |
| 16 | In-vitro matured metaphase-I oocytes have a lower fertilization rate but similar embryo quality as mature metaphase-II oocytes after intracytoplasmic sperm injection显示文摘 | DeVos A Van de Velde H Joris H | 1999 | Hum Reprod1999，14，7： | 1 |
| 17 | The use of?uorescent dyes and probes in surgical oncolo-gy显示文摘 | TE VELDE E A VEERMAN T SUBRAMANIAM V etal | 2010 | EJSO2010，36，1： | 1 |
| 18 | Cell allocation and chromosomal complement of parthenogenetic and IVF bovine embryos显示文摘 | Van De Velde A Liu L Bols P E J | 1999 | Molecular reproduction and development1999，54，1： | 1 |
| 19 | A quantitative re-view of the effects of biochar application to soils on crop productivityusing meta-analysis显示文摘 | Jeffery S Verheijen F G A van der Velde M | 2011 | Agriculture Ecosystems & Environment2011，144，1： | 1 |
| 20 | A quantitative review of the effects of biochar application to soils on crop productivity using meta-analysis显示文摘 | Van Zwicten S Verheijen F G A Van Der Velde M | 2011 | Agriculture Ecosystems and Environment2011，144，1： | 1 |
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