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| 1 | Role of Kupffer cells in the pathogenesis of liver disease显示文摘Kupffer cells, the resident liver macrophages have long been considered as mostly scavenger cells responsible for removing particulate material from the portal circu- lation. However, evidence derived mostly from animal models, indicates that Kupffer cells may be implicated in the pathogenesis of various liver diseases including viral hepatitis, steatohepatitis, alcoholic liver disease, in- trahepatic cholostasis, activation or rejection of the liver during liver transplantation and liver fibrosis. There is accumulating evidence, reviewed in this paper, suggest- ing that Kupffer cells may act both as effector cells in the destruction of hepatocytes by producing harmful soluble mediators as well as antigen presenting cells during viral infections of the liver. Moreover they may represent a significant source of chemoattractant molecules for cy- totoxic CD8 and regulatory T cells. Their role in fibrosis is well established as they are one of the main sources of TGFβ1 production, which leads to the transformation of stellate cells into myofibroblasts. Whether all these variable functions in the liver are mediated by different Kupffer cell subpopulations remains to be evaluated. In this review we propose a model that demonstrates the role of Kupffer cells in the pathogenesis of liver disease. | George Kolios Vassilis Valatas Elias Kouroumalis | 2006 | World Journal of Gastroenterology2006，12，46： | 74 |
| 2 | Intussusception of the bowel in adults:A review显示文摘Intussusception of the bowel is defined as the telescop-ing of a proximal segment of the gastrointestinal tract within the lumen of the adjacent segment.This condi-tion is frequent in children and presents with the classic triad of cramping abdominal pain,bloody diarrhea and a palpable tender mass.However,bowel intussusception in adults is considered a rare condition,accounting for 5% of all cases of intussusceptions and almost 1%-5%of bowel obstruction.Eight to twenty percent of cases are idiopathic,without a lead point lesion.Secondary intus-susception is caused by organic lesions,such as inflam-matory bowel disease,postoperative adhesions,Meckel's diverticulum,benign and malignant lesions,metastatic neoplasms or even iatrogenically,due to the presence of intestinal tubes,jejunostomy feeding tubes or after gas-tric surgery.Computed tomography is the most sensitive diagnostic modality and can distinguish between intus-susceptions with and without a lead point.Surgery is the definitive treatment of adult intussusceptions.Formal bowel resection with oncological principles is followed for every case where a malignancy is suspected.Reduction of the intussuscepted bowel is considered safe for benign lesions in order to limit the extent of resection or to avoid the short bowel syndrome in certain circumstances. | Athanasios Marinis Anneza Yiallourou Lazaros Samanides Nikolaos Dafnios Georgios Anastasopoulos Ioannis Vassiliou Theodosios Theodosopoulos | 2009 | World Journal of Gastroenterology2009，15，4： | 31 |
| 3 | Erectile dysfunction after transurethral prostatectomy for lower urinary tract symptoms:results from a center with over 500 patients显示文摘瞄准:为良性的职业人员静电干扰增生(BPH ) 在前列腺(TURP ) 的经尿道切除术以后为可勃起的机能障碍(编辑) 识别可能的风险因素。方法:在 1999 年 3 月和 2004 年 3 月之间, 629 个病人为征兆的 BPH 的治疗在我们的部门经历了 TURP。所有病人经历了 transrectal 超声检查。另外,流动率,尿残余,国际前列腺症状分数(IPSS ) 和生命(QOL ) 的质量为没有一根导管,介绍了的那些被记录。最后,病人的可勃起的功能根据可勃起的功能仪器(IIEF-5 ) 问询表的国际索引被评估。在哪儿有不到 21 的一个全部的分数,被决定编辑存在。流动率, IPSS 和 QOL 评价在 3 和 6 个月被执行处理以后。IIEF-5 评价在 6 月的后续被重复。逻辑回归分析被用来鉴别潜力为编辑结果冒因素的风险:在基线, 522 (83%) 病人们回答了 IIEF-5 问询表。吝啬的耐心的年龄是(63.7+/-9.7 ) 年。编辑率是 65% 。在 6 个月以后,(88%) 459 从 522 个病人归还了 IIEF 问询表。这个组的其余部分从统计分析被排除。在 TURP 以后的六个月,报导编辑的病人的率增加了到 77% 。统计分析表明在 TURP 以后与最新报导的编辑联系的唯一的重要因素是糖尿病(P = 0.003, r = 3.67 ) 并且观察 intraoperative 胶囊的穿孔(P = 0.02, r = 1.12 ) 。结论:在 TURP 以后的手术后的、最新报导的编辑的发生是 12% 。为它的出现的风险因素是糖尿病和 intraoperative 胶囊的穿孔。 | Vassilis Poulakis Nikolaos Ferakis Ulrich Witzsch Rachelle de Vries Eduard Becht | 2006 | Asian Journal of Andrology2006，8，1： | 21 |
| 4 | Role of radiotherapy in the management of hepatocellular carcinoma:A systematic review显示文摘Many patients with hepatocellular carcinoma(HCC) present with advanced disease,not amenable to curative therapies such as surgery,transplantation or radiofrequency ablation. Treatment options for this group of patients include transarterial chemoembolization(TACE) and radiation therapy. Especially TACE,delivering a highly concentrated dose of chemotherapy to tumor cells while minimizing systemic toxicity of chemotherapy,has given favorable results on local control and survival. Radiotherapy,as a therapeutic modality of internal radiation therapy with radioisotopes,has also achieved efficacious tumor control in advanced disease. On the contrary,the role of external beam radiotherapy for HCC has been limited in the past,due to the low tolerance of surrounding normal liver parenchyma. However,technological innovations in the field of radiotherapy treatment planning and delivery,have provided the means of delivering radical doses to the tumor,while sparing normal tissues. Advanced and highly conformal radiotherapy approaches such as stereotactic body radiotherapy and proton therapy,evaluated for efficacy and safety for HCC,report encouraging results. In this review,we present the role of radiotherapy in hepatocellular carcinoma patients not suitable for radical treatment. | Maria-Aggeliki Kalogeridi Anna Zygogianni George Kyrgias John Kouvaris Sofia Chatziioannou Nikolaos Kelekis Vassilis Kouloulias | 2015 | World Journal of Hepatology2015，7，1： | 18 |
| 5 | Association between polymorphisms in the Toll-like receptor 4,CD14,and CARD15/NOD2and inflammatory bowel disease in the Greek population显示文摘AIM: Crohn's disease(CD)and ulcerative colitis(UC)are multifactorial diseases with a significant genetic background.Apart from CARD15/NOD2 gene, evidence is accumulating that molecules related to the innate immune response such as CD14 or Toll-like receptor 4 (TLR4), are involved in their pathogenesis. In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp,Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.METHODS: DNA was obtained from 120 patients with CD,85 with UC and 100 healthy individuals. Genotyping was performed by allele specific PCR or by PCR-RFLP analysis.RESULTS: The 299Gly allele frequency of the TLR4 gene and the T allele and TT genotype frequendes of the CD14 promoter were significantly higher in CD patients only compared to healthy individuals (P = 0.026<0.05; P = 0.0048<0.01 and P= 0.047<0.05 respectively). Concerning the NOD2/CARD15mutations the overall presence in CD patients was significantly higher than that in UC patients or in controls.Additionally, 51.67% of the CD patients were carriers of a TLR4 and/or CD14 polymorphic allele and at least one variant of the NOD2/CARD15, compared to 27% of the UC patients. It should be pointed out that both frequencies significantly increased as compared with the 10% frequency of multiple carriers found in healthy controls. A possible interaction of the NOD2/CARD15 with TLR4 and especially CD14, increased the risk of developing inflammatory bowel disease (IBD).CONCLUSION: Our results indicate that co-existence of a mutation in either the TLR4 or CD14 gene, and in NOD2/CARD15is associated with an increased susceptibility to developing CD compared to UC, and to developing either CD or UC compared to healthy individuals. | Maria Gazouli Gerassimos Mantzaris Athanassios Kotsinas Panayotis Zacharatos Efstathios Papalambros Athanassios Archimandritis John Ikonomopoulos Vassilis G Gorgoulis | 2005 | World Journal of Gastroenterology2005，11，5： | 17 |
| 6 | Acute upper gastrointestinal bleeding in octοgenarians:Clinical outcome and factors related to mortality显示文摘AIM: To evaluate the aetiology, clinical outcome and factors related to mortality of acute upper gastrointestinal bleeding (AUGIB) in octogenarians. METHODS: We reviewed the records of all patients over 65 years old who were hospitalised with AUGIB in two hospitals from January 2006 to December of 2006. Patients were divided into two groups: Group A (65-80 years old) and Group B (> 80 years old). RESULTS: Four hundred and sixteen patients over 65 years of age were hospitalized because of AUGIB. Group A included 269 patients and Group B 147 patients. Co-morbidity was more common in octogenarians (P = 0.04). The main cause of bleeding was peptic ulcer in both groups. Rebleeding and emergency surgery were uncommon in octogenarians and not different from those in younger patients. In-hospital complications were more common in octogenarians (P = 0.05) and more patients died in the group of octogenarians compared to the younger age group (P = 0.02). Inability to perform endoscopic examination (P = 0.002), presence of high risk for rebleeding stigmata (P = 0.004), urea on admission (P = 0.036), rebleeding (P = 0.004) and presenceof severe co-morbidity (P < 0.0001) were related to mortality. In multivariate analysis, only the presence of severe co-morbidity was independently related to mortality (P = 0.032). CONCLUSION: While rebleeding and emergency surgery rates are relatively low in octogenarians with AUGIB, the presence of severe co-morbidity is the main factor of adverse outcome. | George J Theocharis Vassiliki Arvaniti Stelios F Assimakopoulos Konstantinos C Thomopoulos Vassilis Xourgias Irini Mylonakou Vassiliki N Nikolopoulou | 2008 | World Journal of Gastroenterology2008，14，25： | 15 |
| 7 | Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells(strem-1) in peptic ulcer disease显示文摘AIM: To investigate the role of gastric mucosa at the secretion of sTREM-1 in peptic ulcer. METHODS: Seventy two patients were enrolled; 35 with duodenal, 21 with gastric ulcer and 16 with chronic gastritis. Patients were endoscoped and gastric juice was aspirated. Patients with duodenal and gastric ulcer underwent a second endoscopy post-treatment. Biopsies were incubated in the absence/presence of endotoxins or gastric juice. Supernatants were collected and sTREM-1 and TNFα were measured by enzyme immunoabsorbent assays. Scoring of gastritis was performed before and after treatment according to updated Sydney score. RESULTS: Patients with duodenal and gastric ulcer and those with chronic gastritis had similar scores of gastritis. sTREM-1 was higher in supernatants of tissue samples of H pylori-positive than of H pylori-negative patients with gastric ulcer. Median (± SE) sTREM-1 was found increased in supernatants of patients with gastric ulcer before treatment (203.21 ± 88.91 pg/1000 cells) compared to supernatants either from the same patients post-treatment (8.23 ± 5.79 pg/1000 cells) or from patients with chronic gastritis (6.21 ± 0.71 pg/1000 cells) (P < 0.001 and < 0.001, respectively). Similar differences for sTREM-1 were recorded among LPS-stimulated tissue samples of patients (P = 0.001). Similar differences were not found for TNFα. Positive correlations were found between sTREM-1 of supernatants from patients withboth duodenal and gastric ulcer before treatment and the degree of infiltration of neutrophils and monocytes. CONCLUSION: sTREM-1 secreted by the gastric mucosa is an independent mechanism connected to the pathogenesis of peptic ulcer. sTREM-1 was released at the presence of H pylori from the inflamed gastric mucosa in the field of gastric ulcer. | Vassilios Koussoulas Spyridon Vassiliou Ekaterini Spyridaki Maria Demonakou Ilia Vaki Charalambos Barbatzas Helen Giamarellou Evangelos J Giamarellos-Bourboulis | 2007 | World Journal of Gastroenterology2007，13，34： | 11 |
| 8 | Inferior vena cava obstruction and collateral circulation as unusual manifestations of hepatobiliary cystadenocarcinoma显示文摘BACKGROUND: Hepatobiliary cystadenocarcinoma represents a rare epithelial malignant tumor derived from the intrahepatic bile duct. METHODS: A 71-year-old woman, who had undergone laparoscopic drainage of a cystic lesion of the right hepatic lobe, was misdiagnosed as having hepatic echinococcal disease, and received intracystic infusion of 95% ethanol four years ago. She was admitted to our hospital for further treatment. RESULTS: Physical examination revealed dilated superficial veins across the right abdominal wall. After mapping the direction of blood flow in these vessels, we assumed that this was a sign of inferior vena cava obstruction. Abdominal ultrasound, computed tomography, magnetic resonance imaging combined with magnetic resonance angiography showed a large cystic mass in the right upper quadrant and epigastrium, displacing the adjacent structures, adherent to the inferior vena cava, which was not patent, resulting in dilation of superficial epigastric veins. The patient underwent an exploratory laparotomy. Total excision of the huge mass measuring 16×15 cm was possible under selective vascular exclusion of the liver. Removal of the tumor resulted in immediate restoration of flow in the inferior vena cava. On the basis of the pathology and findings of immunohistochemical analysis, a hepatobiliary cystadenocarcinoma was diagnosed.CONCLUSIONS: In the present case, hepatobiliary cystadenocar-cinoma was accompanied by dilated superficial venous collaterals due to inferior vena cava obstruction. Selective vascular exclusion of the liver allowed a safe oncological resection of the tumor. | Nikolaos Arkadopoulos Anneza I Yiallourou Constantinos Palialexis Emmanouil Stamatakis Evi Kairi-Vassilatou Vassilis Smyrniotis | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 10 |
| 9 | A case of hepatocellular carcinoma arising within large focal nodular hyperplasia with review of the literature显示文摘Focal nodular hyperplasia (FNH) is a relatively rare benign hepatic tumor, usually presenting as a solitary lesion; however, multiple localizations have also been described. The association of FNH with other hepatic lesions, such as adenomas and haemangiomas has been reported by various authors. We herein report a case of a hepatocellular carcinoma arising within a large focal nodular hyperplasia, in a young female patient. | Theodoros Petsas Athanasios Tsamandas Irene Tsota Dionisios Karavias Chrysoula Karatza Vassilios Vassiliou Dimitrios Kardamakis | 2006 | World Journal of Gastroenterology2006，12，40： | 10 |
| 10 | Surgical approaches of resectable synchronous colorectal liver metastases:Timing considerations显示文摘AIM: To compare the safety and efficacy of simultaneous versus two stage resection of primary colorectal tumors and liver metastases. METHODS: From January 1996 to May 2004, 103 colorectal tumor patients presented with synchronous liver metastases. Twenty five underwent simultaneous colorectal and liver surgery and 78 underwent liver surgery 1-3 mo after primary colorectal tumor resection. Data were retrospectively analyzed to assess and compare the morbidity and mortality between the surgical strategies. The two groups were comparable regarding the age and sex distribution, the types of liver resection and stage of primary tumors, as well as the number and size of liver metastases. RESULTS: In two-stage procedures more transfusions were required (4 ± 1.5 vs 2 ± 1.8, pRBCs, P < 0.05). Chest infection was increased after the two-stage approach (26% vs 17%, P < 0.05). The two-stage procedure was also associated with longer hospitalization (20 ± 8 vs 12 ± 6 d, P < 0.05). Five year survival in both groups was similar (28% vs 31%). No hospital mortality occurred in our series. CONCLUSION: Synchronous colorectal liver metastases can be safely treated simultaneously with the primary tumor. Liver resection should be prioritized over colon resection. It is advisable that complex liver resections with marginal liver residual volume should be dealt with at a later stage. | Ioannis Vassiliou Nick Arkadopoulos Theodosios Theodosopoulos Georgios Fragulidis Athanasios Marinis Agathi Kondi-Paphiti Lazaros Samanides Andreas Polydorou Constantinos Gennatas Dionysios Voros Vassilios Smyrniotis | 2007 | World Journal of Gastroenterology2007，13，9： | 8 |
| 11 | Photocatalytic oxidation of gaseous benzene,toluene and xylene under UV and visible irradiation over Mn-doped TiO_(2)nanoparticles显示文摘The photocatalytic oxidation of gaseous benzene,toluene and xylene(BTX)over un-doped,0.1 and 1 wt%Mn-TiO_(2)nanoparticles under ultraviolet and visible irradiation was studied in atmosphere of synthetic air or inert gas.The photocatalytic decomposition efficiency and the oxidation products were determined using a Static Photochemical Reactor coupled with FTIR spectroscopy.BTX underwent efficient decomposition over Mn-TiO_(2)photocatalysts under UV irradiation,more with oxygen presence and less without oxygen.More important toluene and xylene went substantial decomposition over 0.1 mol%Mn-TiO_(2)under visible irradiation with oxygen presence.The main final oxidation products in the UV photocatalysis of BTX were CO_(2),CO and H2O,with CO_(2) and CO yields 4 and 2 respectively.The conversion percentage of benzene,toluene,and xylene to CO_(2) were 63.6%,56.4%,51.8%,and to CO 29%,26.5%,23.2%,respectively.In the visible photocatalysis of toluene and xylene the yields of CO were insignificant.Formation of carbon containing deposits on TiO_(2)surfaces was observed after extensive UV photocatalysis of toluene and xylene,and such by-products surface coverage may reduce the photocatalytic activity of TiO_(2)samples.Some aspects of the photocatalytic mechanism were examined. | Vassilios Binas Vassilis Stefanopoulos George Kiriakidis Panos Papagiannakopoulos | 2019 | Journal of Materiomics2019，5，1： | 5 |
| 12 | Extracorporeal shockwave therapy for Peyronie's disease: an alternative treatment?显示文摘瞄准:回顾地与 Peyronie 的疾病在病人决定身体外的冲击波治疗(ESWT ) 的安全和功效。方法:有稳定的 Peyronie 的疾病的 53 个病人经历了 ESWT (组 1 ) 。与在组 1 的病人,没接受治疗,的基线特征匹配的十五个病人被用作控制(组 2 ) 。病人的可勃起的功能(可勃起的功能的国际索引[IIEF-5 ] 分数) ,疼痛严厉(视觉模拟规模) ,匾尺寸和阴茎作成角的度在组 2 在组 1 并且在后续期间在治疗前后被估计。结果:吝啬的后续时间是 32 个月(范围:6-64 月) 在组 1 和 35 月内(变化:9-48 月) 在组 2。所有病人为后续是可得到的。就可勃起的功能和匾尺寸而言,没有重要变化(P >
0.05 ) 在在 ESWT 前后的组 1 被观察。39 个病人(74%) 的一个总数在在 ESWT 以后的组 1 在疼痛地势报导了重要效果。关于疼痛地的改进,然而, IIEF-5 分数和匾缩放,没有有效差量在二个组之间被观察。在组 1 的 21 个病人(40%) ,偏差角度被减少有在 11 度的所有病人的吝啬的减小的超过 10 度(范围:6-20 度) 。没有严肃的复杂并发症就 ESWT 过程而言被注意。结论:ESWT 是为 Peyronie 的疾病的治疗的一个最低限度地侵略、安全的其他的过程。然而,阴茎疼痛,性功能和匾尺寸上的 ESWT 的效果仍然保持可疑。 | Vassilis Poulakis Konstantinos Skriapas Rachelle de Vries Wolfgang Dillenburg Nikolaos Ferakis Ulrich Witzsch Michael Melekos Edward Becht | 2006 | Asian Journal of Andrology2006，8，3： | 5 |
| 13 | Porosity of 3D biomaterial scaffolds and osteogenesis显示文摘 | Vassilis Karageorgiou David Kaplan | 2005 | Biomaterials2005，，27： | 4 |
| 14 | Observations of kinetic Alfvén waves by THEMIS near a substorm onset显示文摘Low frequency electromagnetic fluctuations in the vicinity of a magnetospheric substorm onset were investigated using simultaneous observations by THEMIS multiple probes in the near-Earth plasma sheet in the magnetotail.The observations indicate that in the vicinity of a substorm onset,kinetic Alfvén waves can be excited in the high-βplasma sheet(β=2μ0nT/B 2 ,the ratio of plasma thermal pressure to magnetic pressure)within the near-Earth magnetotail.The kinetic Alfvén wave has a small spatial scale in the high-βplasma.The parallel electric field accompanying kinetic Alfvén waves accelerates the charged particles along the magnetic field.The kinetic Alfvén waves play an important role in the substorm trigger process,and possibly in the formation of a substorm current wedge. | DUAN SuPing LIU ZhenXing ANGELOPOULOS Vassilis | 2012 | Chinese Science Bulletin2012，57，12： | 3 |
| 15 | Braking of high-speed flows in the magnetotail:THEMIS joint observations显示文摘The motion and deceleration processes of plasma sheet high-speed flows have great significance to magnetospheric particle acceleration,magnetic field perturbation,magnetic flux transport,triggering of substorm,and the current system formation in the magnetotail.From February to April 2009,two satellites of the Time History of Events and Macroscale Interactions during Substorms mission,THA and THE,were often separated largely in Z direction,but had small X and Y separations.Such special configuration allows simultaneous observations of highspeed flows at the center and boundary of the plasma sheet.Based on selected case study and statistical analysis,it is found that for about 89%of the events we selected,the probe further away from the neutral sheet observed the high-speed flow earlier than the one close to the center,and the flow is mainly field aligned.And for about 95%events the probe further away from the neutral sheet observed higher X component of the plasma flow.With the hypothesis that parallel flow keeps the same speed during its earthward propagation while central plasma sheet stream uniformly or suddenly brakes on its way to the earth,we deduced the position where the deceleration begins to be between 13 Re and 17 Re downtail,where thenear-earth reconnection is supposed to occur.In addition,our statistical results show that dipolarization fronts observed in the central plasma sheet are more prominent than those observed in the plasma sheet boundary layer ahead of the high-speed flow. | Wensai Shang Zhonghua Yao Quanqi Shi Weijie Sun Suiyan Fu Jiang Liu Anmin Tian Qiugang Zong Zuyin Pu Ting Xiao Vassilis Angelopoulos | 2014 | Chinese Science Bulletin2014，59，3： | 3 |
| 16 | LINX^(■) reflux management system to bridge the “treatment gap” in gastroesophageal reflux disease: A systematic review of 35 studies显示文摘BACKGROUND Gastroesophageal reflux disease(GERD) occurs when the reflux of stomach contents causes troublesome symptoms and/or complications. When medical therapy is insufficient, surgical therapy is indicated and, until now, Laparoscopic fundoplication(LF) constitutes the gold-standard method. However, magnetic sphincter augmentation(MSA) using the LINX^® Reflux Management System has recently emerged and disputes the standard therapeutic approach.AIM To investigate the device’s safety and efficacy in resolving GERD symptoms.METHODS This is a systematic review conducted in accordance to the PRISMA guidelines.We searched MEDLINE, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL databases from inception until September 2019.RESULTS Overall, 35 studies with a total number of 2511 MSA patients were included and analyzed. Post-operative proton-pump inhibitor(PPI) cessation rates reached 100%, with less bloating symptoms and a better ability to belch or vomit in comparison to LF. Special patient groups(e.g., bariatric or large hiatal-hernias)had promising results too. The most common postoperative complication was dysphagia ranging between 6% and 83%. Dilation due to dysphagia occurred in 8% of patients with typical inclusion criteria. Esophageal erosion may occur in up to 0.03% of patients. Furthermore, a recent trial indicated MSA as an efficient alternative to double-dose PPIs in moderate-to-severe GERD.CONCLUSION The findings of our review suggest that MSA has the potential to bridge the treatment gap between maxed-out medical treatment and LF. However, further studies with longer follow-up are needed for a better elucidation of these results. | Dimitrios Schizas Aikaterini Mastoraki Eleni Papoutsi Vassilis G Giannakoulis Prodromos Kanavidis Diamantis Tsilimigras Dimitrios Ntourakis Orestis Lyros Theodore Liakakos Dimitrios Moris | 2020 | World Journal of Clinical Cases2020，8，2： | 3 |
| 17 | Renal transplantation with expanded criteria donors: Which is the optimal immunosuppression?显示文摘The growing gap between demand and supply for kidney transplants has led to renewed interest in the use of expanded criteria donor(ECD) kidneys in an effort to increase the donor pool. Although most studies of ECD kidney transplantation confirm lowerallograft survival rates and, generally, worse outcomes than standard criteria donor kidneys, recipients of ECD kidneys generally have improved survival compared with wait-listed dialysis patients, thus encouraging the pursuit of this type of kidney transplantation. The relative benefits of transplantation using kidneys from ECDs are dependent on patient characteristics and the waiting time on dialysis. Because of the increased risk of poor graft function, calcineurin inhibitor(CNI)-induced nephrotoxicity, increased incidence of infections, cardiovascular risk, and malignancies, elderly recipients of an ECD kidney transplant are a special population that requires a tailored immunosuppressive regimen. Recipients of ECD kidneys often are excluded from transplant trials and, therefore, the optimal induction and maintenance immunosuppressive regimen for them is not known. Approaches are largely center specific and based upon expert opinion. Some data suggest that antithymocyte globulin might be the preferred induction agent for elderly recipients of ECD kidneys. Maintenance regimens that spare CNIs have been advocated, especially for older recipients of ECD kidneys. CNI-free regimens are not universally accepted due to occasionally high rejection rates. However, reduced CNI exposure and CNI-free regimens based on mammalian target of rapamycin inhibitors have shown acceptable outcomes in appropriately selected ECD transplant recipients. | Vassilis Filiopoulos John N Boletis | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 18 | Mechanisms of resistance to anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer显示文摘Metastatic colorectal cancer (mCRC) continues to be counted as a major health problem. The introduction of newer cytotoxics, irinotecan and oxaliplatin, has achieved a significant improvement in survival rates. Novel targeted therapies (bevacizumab, and cetux-imab) in combination with most efficient chemotherapy regimens have pushed the median survival beyond the 2-year mark and increased the proportion of patients which could benefit from resection of metastatic lesions. In addition, several studies have proved that the CRC mutation profiles should influence patient selection or stratif ication in prospective trials. KRAS mutational status represents a paradigm for biomarker development in the era of molecular targeted therapies. The present article is an overview of the most important studies in the development of biomarkers for the optimization of anti-epidermal growth factor receptor (anti-EGFR) treatment in mCRC, beyond KRAS mutations, which is a work in progress. The aim will be to identify molecular markers that might be used to select patients with a higher probability of response to anti-EGFR monoclonal antibodies. Overall the accumulating evidence of the molecular biology of CRC has substantially changed the approach to mCRC treatment and has given clinicians more rational options for treating this illness. | Zacharenia Saridaki Vassilis Georgoulias John Souglakos | 2010 | World Journal of Gastroenterology2010，16，10： | 3 |
| 19 | Impact of a trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study显示文摘 | Chao Li Francesco Carli Lawrence Lee Patrick Charlebois Barry Stein Alexander S. Liberman Pepa Kaneva Berson Augustin Mingkwan Wongyingsinn Ann Gamsa Do Jun Kim Melina C. Vassiliou Liane S. Feldman | 2013 | Surgical Endoscopy2013，，4： | 3 |
| 20 | Prognostic and predictive significance of MSI in stages Ⅱ/Ⅲ colon cancer显示文摘In colon cancer,classic disease staging remains the key prognosis and treatment determinant.Although adjuvant chemotherapy has an established role in stageⅢcolon cancer patients,in stageⅡit is still a subject of controversy due to its restriction to a small subgroup of patients with high-risk histopathologic features.Patients with stageⅡtumors form a highly heterogeneous group,with five-year relative overall survival rates ranging from 87.5%(ⅡA)to 58.4%(ⅡC).Identifying those for whom adjuvant chemotherapy would be appropriate and necessary has been challenging,and prognostic markers which could serve in the selection of patients more likely to recur or benefit from adjuvant chemotherapy are eagerly needed.The stronger candidate in this category seems to be microsatellite instability(MSI).The recently reported European Society for Medical Oncology guidelines suggest that MSI should be evaluated in stageⅡcolorectal cancer patients in order to contribute in treatment decisionmaking regarding chemotherapy administration.Thehypothetical predictive role of MSI regarding its response to 5-fluorouracil-based adjuvant chemotherapy has proven a much more difficult issue to address.Almost every possible relation between MSI and chemotherapy outcome has been described in the adjuvant colon cancer setting in the international literature,and the matter is far from being settled.In this current report we critically evaluate the prognostic and predictive impact of MSI status in patients with stageⅡand stageⅢcolon cancer patients. | Zacharenia Saridaki John Souglakos Vassilis Georgoulias | 2014 | World Journal of Gastroenterology2014，20，22： | 3 |
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