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| 1 | Ovarian cancer standard of care: are there real alternatives?显示文摘Ovarian cancer remains a major issue for gynecological oncologists, and most patients are diagnosed when the disease is already advanced with a poor chance of survival. Debulking surgery followed by platinum-taxane chemotherapy is the current standard of care, but based on several different strategies currently under evaluation, some encouraging data have been published in the last 4 to 5 years. This review provides a state-of-the-art overview of the available alternatives to conventional treatment and the most promising new combinations. For example, neoadjuvant chemotherapy does not seem to be inferior to primary debulking. Despite its outcome improvements, intraperitoneal chemotherapy struggles for acceptance due to the heavy toxicity. Dose-dense chemotherapy, after showing an impressive efficacy in Asian populations, has not produced equal results in a European cohort, and the results of alternative platinum doublets are not superior to those of carboplatin and paclitaxel. In this setting, adherence to a maintenance therapy after first-line treatment and multiple(primarily antiangiogenic) agents appears to be effective. Although many questions, including the duration of maintenance treatment and the use of bevacizumab beyond progression, remain unanswered, new biologic agents, such as poly(ADP-ribose) polymerase(PARP) inhibitors, nintedanib, and mitogen-activated protein/extracellular signal-regulated kinase(MEK) inhibitors, have emerged as potential therapeutic options in the very near future. Based on the multiplicity of available strategies, the histological and molecular features of the tumor, in addition to patient's clinical condition and disease state, continue to gain importance in guiding treatment choices. | Chiara Della Pepa Giuseppe Tonini Carmela Pisano Marilena Di Napoli Sabrina Chiara Cecere Rosa Tambaro Gaetano Facchini Sando Pignata | 2015 | Chinese Journal of Cancer2015，34，1： | 5 |
| 2 | Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model显示文摘AIM To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate.METHODS Dexamethasone cholesteryl butyrate-solid lipid nanoparticles(Dx Cb-SLN) were obtained with the warm microemulsion method. The anti-inflammatory activity of this novel nanoformulation has been investigated in vitro(cell adhesion to human vascular endothelial cells and pro-inflammatory cytokine release by lipopolysaccharideinduced polymorphonuclear cells) and in vivo(disease activity index and cytokine plasma concentrations in a dextran sulfate sodium-induced mouse colitis) models. Each drug was also administered separately to compare its effects with those induced by their co-administration in SLN at the same concentrations.RESULTS Dx Cb-SLN at the lowest concentration tested(Dx 2.5 nmol/L and Cb 0.1 μmol/L) were able to exert a more than additive effect compared to the sum of the individual effects of each drug, inducing a significant in vitro inhibition of cell adhesion and a significant decrease of pro-inflammatory cytokine(IL-1β and TNF-α) in both in vitro and in vivo models. Notably, only the Dx Cb nanoformulation administration was able to achieve a significant cytokine decrease compared to the cytokine plasma concentration of the untreated mice with dextran sulfate sodium-induced colitis. Specifically, Dx Cb-SLN induced a IL-1β plasma concentration of 61.77% ± 3.19%, whereas Dx or Cb used separately induced a concentration of 90.0% ± 2.8% and 91.40% ± 7.5%, respectively; Dx Cb-SLN induced a TNF-α plasma concentration of 30.8% ± 8.9%, whereas Dx or Cb used separately induced ones of 99.5% ± 4.9% and 71.1% ± 10.9%, respectively.CONCLUSION Our results indicate that the co-administration of dexamethasone and butyrate by nanoparticles may be beneficial for inflammatory bowel disease treatment. | Chiara Dianzani Federica Foglietta Benedetta Ferrara Arianna Carolina Rosa Elisabetta Muntoni Paolo Gasco Carlo Della Pepa Roberto Canaparo Loredana Serpe | 2017 | World Journal of Gastroenterology2017，23，23： | 3 |
| 3 | Impact of a trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study显示文摘 | Chao Li Francesco Carli Lawrence Lee Patrick Charlebois Barry Stein Alexander S. Liberman Pepa Kaneva Berson Augustin Mingkwan Wongyingsinn Ann Gamsa Do Jun Kim Melina C. Vassiliou Liane S. Feldman | 2013 | Surgical Endoscopy2013，，4： | 3 |
| 4 | Waterborne acrylic-epoxy coatings 显示文摘 | Hegedus C R Pepa F R Dickenson J B | 2002 | JCT2002，74，927： | 1 |
| 5 | Damage-induced permeability changes in granite: a case example at the URL in Canada显示文摘 | Souley M Homand F Pepa S Hoxha D | 2001 | International Journal of Rock Mechanics and Mining Sciences2001，38，2： | 1 |
| 6 | Damage-induced permeability changes in granite: a case example at the URL in Canada显示文摘 | M. Souley F. Homand S. Pepa D. Hoxha | 2001 | International Journal of Rock Mechanics and Mining Sciences2001，，： | 1 |
| 7 | Update on the surgical man- agement of adenomyosis显示文摘 | Pepas L Deguara C Davis C | 2012 | Curt ()pin Obstet Gynecol2012，24，25： | 1 |
| 8 | Neuromodulation of vegetative state through spinal cord stimulation:where are we now and where are we going? 显示文摘 | Della Pepa GM Fukaya C La Rocca G | 2013 | Stereotact Funct Neurosurg2013，91，5： | 1 |
| 9 | Surgical interventions for high grade vulval intraepithelial显示文摘 | Kaushik S Pepas L Nordin A | 2011 | Cochrane Database Syst Rev2011，，00： | 1 |
| 10 | Global Assessment of Gastrointestinal Endoscopic Skills (GAGES): a valid measurement tool for technical skills in flexible endoscopy显示文摘 | Melina C. Vassiliou Pepa A. Kaneva Benjamin K. Poulose Brian J. Dunkin Jeffrey M. Marks Riadh Sadik Gideon Sroka Mehran Anvari Klaus Thaler Gina L. Adrales Jeffrey W. Hazey Jenifer R. Lightdale Vic Velanovich Lee L. Swanstrom John D. Mellinger Gerald M. F | 2010 | Surgical Endoscopy2010，，8： | 1 |
| 11 | The influence of a baccalaureate program on traditional, RN-BSN, and accelerated students'critical thinking abilities显示文摘 | Brown J M Alverson E M Pepa C A | 2001 | Holi Nurs Prac2001，15，3： | 1 |
| 12 | An eehocardiographie study of te- tralogy of Fallot in the tetus and infant显示文摘 | Pepas LP Savis A Jones A | 2003 | Cardiol Young2003，13，： | 1 |
| 13 | Vitamin D and Calxliovascular Disease: Is There Evidence to Suppprt the Band- wagon? 显示文摘 | ANNUZZI G DELLA PEPA G VETRANI C | 2012 | Curt Atheroseler Rep2012，14，6： | 1 |
| 14 | Prevalence of faecal-borne parasites in colony stray cats in Northern Italy显示文摘 | Spada E Proverbio D Della Pepa A | 2013 | J Feline Med Surg2013，15，8： | 1 |
| 15 | Damage-induced permeability changes in granite:a case example at the URL in Canada显示文摘 | SOULEY M HOMAND F PEPA S | 2001 | Int J Rock Mech Min Sci2001，38，： | 1 |
| 16 | Abrupt clinical onset of Chiari type I/syringomyelia complex: clinical and physiopathological implications显示文摘 | Massimi L Della Pepa GM Caldarelli M | 2012 | Neurosurg Rev2012，35，3： | 1 |
| 17 | Testing the construct validity of the Simbionix GI Mentor II virtual reality colonoscopy simulator metrics: module matters显示文摘 | Raad Fayez Liane S. Feldman Pepa Kaneva Gerald M. Fried | 2010 | Surgical Endoscopy2010，，5： | 1 |
| 18 | Non - ionic surfactant modified ligand exchange chromatography using copper (II) complex of N, N - dimethyl - 1 - phenylalanine as the chiral additive for enantioselective amino acids separation显示文摘 | Dimitrova Pepa Bart Hans - Jorg | 2010 | Analytica Chimica Ac- ta2010，663，： | 1 |
| 19 | Evaluation of therapeutic riding (Sweden)/hippotherapy (United States). A single-subject experimental design study replicated in eleven patients with multiple sclerosis显示文摘 | Ann Hammer Ylva Nilsag? rd Anette Forsberg Helena Pepa Elisabeth Skargren Birgitta ? berg | 2005 | Physiotherapy Theory and Practice2005，，1： | 1 |
| 20 | Inverter EMI modeling and simula- tion methodologies显示文摘 | Lai J S Huang X D Pepa E | 2006 | IEEE Transactions on Industrial Electronics2006，53，3： | 1 |
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