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| 1 | Crop Breeding Chips and Genotyping Platforms: Progress, Challenges, and Perspectives显示文摘在为基因在领域庄稼和树印射和发现的分子的标记试金的开发和应用程序有一个很快升起的趋势。因此 ? 远,超过 50 个 SNP 数组和 genotyping-by-sequencing (GBS ) 的 15 种不同类型平台在超过 25 庄稼种类和长期的树被开发了。然而,少得多努力在为引起程序使用开发 ultra-high-throughput 和划算的 genotyping 平台上被作了。在这评论,我们在存在 SNP 数组和 GBS 技术和策略讨论科学瓶颈开发指向的平台为收割分子的繁殖。我们建议实际繁殖平台应该采用的那未来自动化了 genotyping 技术,任何一个数组或定序基于,目标 ? 功能的多型性 underpinning 经济特点,并且为量的特点提供理想的预言精确性,用在在庄稼的宽基因背景下面的通用应用程序。如此的平台的发展在庄稼植物由于大遗传型显型差距由于费用低效率,和知识水平在工艺的水平面对严肃的挑战。如此的 genotyping 平台将在考虑在主要庄稼在下一十年里被完成,这被期望?(a)快速的开发?在重要特点的基因发现,(b)通过新分析模型和人口图案加深了量的特点的理解,导致基因和为重要繁殖特点负责的小径的鉴定的多层的 -omics 数据的(c)集成,和在大规模 genotyping 的费用有效性的(d)改进。庄稼繁殖芯片和 genotyping 平台将提供崭新的机会与减轻气候变化的效果的需要的收益潜力,质量,和提高的改编加速栽培变种的开发。 | Awais Rasheed Yuanfeng Hao Xianchun Xia Awais Khan Yunbi Xu Rajeev K. Varshney Zh-onghu He | 2017 | Molecular Plant2017，10，8： | 42 |
| 2 | SSR分子标记在花生杂种鉴定中的应用显示文摘以24份花生材料为亲本,配制22个杂交组合,并利用40对SSR引物对24份亲本材料进行多态性筛选,运用多态性引物鉴定92个F1代杂种的真伪.结果表明,不同组合亲本间多态性差异较大,差异最大的两亲本(GT-C20-D和Tamrun OL07)的多态性引物比例为65%.SSR标记法鉴定出49个单株为真杂种;而田间表型鉴定出62个单株为真杂种,与标记鉴定结果差异较大.本研究证实利用分子标记鉴定真假杂种非常必要,且准确可行.同时,本试验证明40对SSR引物具有较高的多态性,可直接用于花生遗传多样性、杂种鉴定以及遗传图谱构建等的研究. | 王辉 KHERA Pawan 李双铃 任艳 袁美 庄伟建 VARSHNEY Rajeev K 郭宝珠 谢联辉 | 2015 | 福建农林大学学报(自然科学版)2015，44，4： | 4 |
| 3 | Identification of ExpIdentification of Expressed Resistance Gene Analogs from Peanut (Arachis hypogaea L.) Expressed Sequence Tags显示文摘Low genetic diversity makes peanut (Arachis hypogaea L.) very vulnerable to plant pathogens, causing severe yield loss and reduced seed quality. Several hundred partial genomic DNA sequences as nucleotide-binding-site leucine-rich repeat (NBS-LRR) resistance genes (R) have been identified, but a small portion with expressed transcripts has been found. We aimed to identify resistance gene analogs (RGAs) from peanut expressed sequence tags (ESTs) and to develop polymorphic markers. The protein sequences of 54 known R genes were used to identify homologs from peanut ESTs from public databases. A total of 1,053 ESTs corresponding to six different classes of known R genes were recovered, and assembled 156 contigs and 229 singletons as peanut-expressed RGAs. There were 69 that encoded for NBS-LRR proteins, 191 that encoded for protein kinases, 82 that encoded for LRR-PK/transmembrane proteins, 28 that encoded for Toxin reductases, 11 that encoded for LRR-domain containing proteins and four that encoded for TM-domain containing proteins. Twenty-eight simple sequence repeats (SSRs) were identified from 25 peanut expressed RGAs. One SSR polymorphic marker (RGA121) was identified. Two polymerase chain reaction-based markers (Ahsw-1 and Ahsw-2) developed from RGA013 were homologous to the Tomato Spotted Wilt Virus (TSWV) resistance gene. All three markers were mapped on the same linkage group AhIV. These expressed RGAs are the source for RGA-tagged marker development and identification of peanut resistance genes. | Zhanji Liu Suping Feng Manish K. Pandey Xiaoping Chen Albert K. Culbreath Rajeev K. Varshney Baozhu Guo | 2013 | Journal of Integrative Plant Biology2013，55，5： | 4 |
| 4 | Promising drug targets and associated therapeutic interventions in Parkinson's disease显示文摘Parkinson's disease(PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limitations of current therapeutic options in PD, novel drug targets for PD, and finally, the role of some critical beneficial natural products to control the progression of PD. | Sachchida Nand Rai Payal Singh Ritu Varshney Vivek K.Chaturvedi Emanuel Vamanu M.P.Singh Brijesh Kumar Singh | 2021 | Neural Regeneration Research2021，16，9： | 4 |
| 5 | Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients显示文摘AIM To investigate the role of genetic variants of angiotensin converting enzyme(ACE) and angiotensinogen(AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy(DN) patients.METHODS In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor(ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio(ACR) in urine. Genotyping of ACE I/D and AGT M235 T polymorphisms were performed by using primer specific polymerase chain reaction(PCR) and PCR-RFLP techniques, respectively. RESULTS Forty-eight percent of DN patients(responders) benefited with respect to proteinuria from ACE inhibitor therapy at 6 mo follow-up. A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric(≥ 30 and < 300 mg/g creatinine) or macro-albuminuric(≥ 300 mg/g creatinine) at the time of enrollment. However, macro-albuminuric patients(55%) showed better response to therapy. A reduction in urinary ACR was found independent of genotypes of ACE I/D and AGT M235 T polymorphisms although macro-albuminuric patients having TT genotype showed statistically insignificant increased response(72%). CONCLUSION ACE inhibitor therapy reduced urinary ACR by ≥ 30% in 50% of DN patients and the response is independent of ACE I/D and AGT M235 T polymorphisms. | Neerja Aggarwal Pawan Kumar Kare Parul Varshney Om Prakash Kalra Sri Venkata Madhu Basu Dev Banerjee Anil Yadav Alpana Raizada Ashok Kumar Tripathi | 2017 | World Journal of Diabetes2017，8，3： | 4 |
| 6 | Genome-wide SNP Genotyping Resolves Signatures of Selection and Tetrasomic Recombination in Peanut显示文摘花生(Arachis hypogaea;2n = 4x = 40 ) 是滋养的食物和维生素,矿物质,和健康脂肪的好来源。扩大基因并且为栽培花生的基因改进的 genomic 资源从栽培花生的双祖先的定序的染色体获得了动量。便于 Arachis 种类的高产量的 genotyping, 20 遗传型被重新定序,染色体宽的单个核苷酸多型性(SNP ) 被选择开发一个大规模 SNP genotyping 数组。为在 genotyping 应用程序的灵活性,在 tetraploid 和双种类之间多态的 SNP 为使用被包括在栽培并且种间的人口。一套 384 就职被用来测试导致生产了在双种类之间的高质量的多态的簇的 54 564 个标记的数组, 47 116 个多态的标记在之间栽培并且种间的混血儿,和在 A 以内的 15 897 个多态的标记。hypogaea germplasm。一另外 1193 个标记被识别那照亮的 genomic 区域展出 tetrasomic 再结合。而且,完成美国跑步者 germplasm 的家谱的一套精英栽培变种是 genotyped 并且过去常识别经历了积极选择的 genomic 区域。这些观察在栽培花生在新基因差异的包括上提供关键卓见并且将通知发展高分辨率的印射的人口。由于它的效率,范围,和灵活性,最新发达的 SNP 数组将为在 Arachis 的进一步基因、引起的应用程序是很有用的。 | Josh Clevenger Ye Chu Carolina Chavarro Gaurav Agarwal David J. Bertioli Soraya C.M. LeaI-Bertioli Manish K. Pandey Justin Vaughn Brian Abernathy Noelle A. Barkley Ran Hovav Mark Burow Spurthi N. Nayak Annapurna Chitikineni Thomas G. Isleib C. Corley Holbrook Scott A. Jackson Rajeev K. Varshney Peggy Ozias-Akins | 2017 | Molecular Plant2017，10，2： | 4 |
| 7 | Exploiting EST databases for the development and characterization of gene-derived SSR-markers in barley (Hordeum vulgare L.)显示文摘 | T. Thiel W. Michalek R. Varshney A. Graner | 2003 | Theoretical and Applied Genetics2003，，3： | 3 |
| 8 | Combustion performance studies of aluminum and boron based composite solid propellants in sub-atmospheric pressure regimes显示文摘The aim of present study is to investigate the burning rate,ignition delay,and flame characteristics of ammonium perchlorate(AP)-hydroxyl terminated poly-butadiene(HTPB)[AP/HTPB]based composite propellants(CSP's)in sub-atmospheric pressure regimes(13 kPae100 kPa).Several fuels and catalyzed were used to evaluate their effects on the combustion characteristics of AP based propellants in sub-atmospheric pressure regimes.In fuels,aluminum(Al)and boron(B)were selected as metallic and non-metallic fuel respectively.While in catalyst,butyl ferrocene(B.F.)and ferric oxide(F.O.)were selected as liquid and solid catalyst respectively.Apart from these,other ingredients that were used are di-octyl adipate(DOA),toluene di-isocyanate(TDI),and glycerol.The article throws some light on the burning rate and ignition delay properties for these new classes of prepared propellant samples.At subatmospheric pressures,all propellants are susceptible to irregular burning with the ejection of soot's,fumes,and unburned particles.F.O.based catalyzed propellants can sustain its combustion up to the lowest pressure. | Pratim Kumar Mayank Varshney Aniket Manash | 2019 | Propulsion and Power Research2019，8，4： | 3 |
| 9 | 创伤性寰枢椎滑脱伴移位型齿状突骨折:采用“关节重塑”技术实现后路完全复位显示文摘寰枢椎脱位(atlantocaxial dislocation,AAD)是在先天性和创伤性情况下,寰枢关节常见的一种不正常关系,寰枢椎滑脱(atlantoaxial spondyloptosis,AAS)是指寰椎侧块小关节面完全移位,两个关节面之间无接触,是寰枢椎不稳定的一种罕见表现,属于最严重的寰枢椎脱位之一。由于寰枢关节面交锁,传统的后路手术方式或单纯凭借颅骨牵引均无法使寰枢椎完全复位。“关节操作”技术最初由Goel等提出,通过术中C1~C2撑开及进行寰枢关节操作实现颅颈交界区的重新对位。但单独使用该技术并不能达到关节复位,因此需要联合关节重塑技术(通过在C1关节面前下方边缘及C2关节面钻孔以辅助骨刀插入,获得撑开及部分复位),使寰枢关节复位到正常的解剖位置。作者对1例创伤性AAS伴移位型齿状突骨折患儿采取单纯后路手术,通过“关节操作”和“关节重塑”技术实现完全复位,效果良好。 | kumar a varshney g singh pk 葛苏 马向阳 | 2018 | 中国骨科临床与基础研究杂志2018，10，1： | 3 |
| 10 | Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity显示文摘Astrocytes protect neurons by modulating neuronal function and survival.Astrocytes support neurons in several ways.They provide energy through the astrocyte-neuron lactate shuttle,protect neurons from excitotoxicity,and internalize neuronal lipid droplets to degrade fatty acids for neuronal metabolic and synaptic support,as well as by their high capacity for glutamate uptake and the conversion of glutamate to glutamine.A recent reported astrocyte system for protection of dopamine neurons against the neurotoxic products of dopamine,such as aminochrome and other o-quinones,were generated under neuromelanin synthesis by oxidizing dopamine catechol structure.Astrocytes secrete glutathione transferase M2-2 through exosomes that transport this enzyme into dopaminergic neurons to protect these neurons against aminochrome neurotoxicity.The role of this new astrocyte protective mechanism in Parkinson´s disease is discussed. | Juan Segura-Aguilar Bengt Mannervik JoséInzunza Mukesh Varshney Ivan Nalvarte Patricia Muñoz | 2022 | Neural Regeneration Research2022，17，9： | 3 |
| 11 | Identification, characterization and utilization of EST-derived genic microsatellite markers for genome analyses of coffee and related species显示文摘 | Ramesh K. Aggarwal Prasad S. Hendre Rajeev K. Varshney Prasanna R. Bhat V. Krishnakumar Lalji Singh | 2007 | Theoretical and Applied Genetics2007，，2： | 2 |
| 12 | Genic microsatellite markers in plants: features and applications显示文摘 | Rajeev K. Varshney Andreas Graner Mark E. Sorrells | 2004 | Trends in Biotechnology2004，，1： | 2 |
| 13 | Distributed detection with multiple sensors显示文摘 | Viswanathan R Varshney P K | 1997 | Proceedings of the IEEE1997，85，1： | 1 |
| 14 | Reducing probability of decision error using stochastic resonance 显示文摘 | S kay J Michels H Chen P Varshney | 2006 | IEEE Signal Processing letter2006，13，11： | 1 |
| 15 | Mesh Saliency显示文摘 | LEE C H VARSHNEY A JACOBS D W | 2005 | ACM Transaction on Graph2005，24，3： | 1 |
| 16 | Molecular markers and their applications in wheat breeding显示文摘 | P K Gupta R K Varshney P C Sharma B Ramesh | 1999 | Plant Breeding1999，118，： | 1 |
| 17 | Mesh saliency显示文摘 | Lee Chang-ha Varshney A Jacobs D W | 2005 | ACM Transactions on Graphics ACM2005，24，3： | 1 |
| 18 | Distributeddetection with multiple sensors:I fundamentals显示文摘 | VISWANATHAN R VARSHNEY P K | 1997 | Proceedings of the IEEE1997，85，1： | 1 |
| 19 | ANN based integrated security assessment of power system using parallel computing显示文摘 | Sarika Varshney Laxmi Srivastava Manjaree Pandit | 2012 | International Journal of Electrical Power and Energy Systems2012，，1： | 1 |
| 20 | Adhesion proteins of Mycoplasma pneumoniae显示文摘 | Chaudhry R Varshney AK Malhotra P | 2007 | Front Biosci2007，12，： | 1 |
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