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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids显示文摘 | M. Alvarez-Lopez María Dolores Pereda J.A. del Valle M. Fernandez-Lorenzo M.C. Garcia-Alonso O.A. Ruano M.L. Escudero | 2009 | Acta Biomaterialia2009，，5： | 3 |
| 3 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 4 | Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids显示文摘 | M. Alvarez-Lopez María Dolores Pereda J.A. del Valle M. Fernandez-Lorenzo M.C. Garcia-Alonso O.A. Ruano M.L. Escudero | 2009 | Acta Biomaterialia2009，，5： | 2 |
| 5 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 6 | Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients显示文摘 | Francesc Vallribera Valls Filippo Landi Eloy Espín Basany José Luis Sánchez García Luis Miguel Jiménez Gómez Marc Martí Gallostra Luis Salgado Cruz Manuel Armengol Carrasco | 2014 | Surgical Endoscopy2014，，12： | 2 |
| 7 | 显示文摘 | del Valle J A Picasso A C Alvarez I | 1999 | Scripta Materialia1999，41，3： | 1 |
| 8 | Intrahepatic peripheral cholangiocarcinoma:CT evaluation显示文摘 | Valls C Guma A Puig I | 2000 | Abdom Imaging2000，25，5： | 1 |
| 9 | Effects of galanin on growth hormone and prolactin secretion in anorexia nervosa 显示文摘 | Maneini A Valle D | 2000 | Metabolism2000，49，： | 1 |
| 10 | Technique and complications of percutaneous nephroscopy:experience with 557 patients in the supine position显示文摘 | Valdivia Uría JG Valle Gerhold J López López JA | 1998 | J Urol1998，160，61： | 1 |
| 11 | Intrahepatic peripheral cholangiocinoma:CT evaluation显示文摘 | Valls C Guma A Puig I | 2006 | Abdom Imaging2006，25，5： | 1 |
| 12 | Extraction-atomic absorption method for the determination of arsenic,antimony,selenium and tellurium in geologic samples显示文摘 | Togov V G Vall G A Demidova M G | 1995 | Chem Geol1995，124，： | 1 |
| 13 | Continuous aspiration of subglottic secretions in preventing ventilator associated pneumonia 显示文摘 | Valles J Artigas A Rello J | 1995 | Ann Intern Med1995，122，： | 1 |
| 14 | DeterInination of the sum of malachite green and leucomalachite green in salmon muscle by liquid chromatography-atmospheric pressure chemical ionisation- mass spectrometry显示文摘 | Valle L Diaz C Zanocco A L | 2005 | J Chromatography A2005，1067，12： | 1 |
| 15 | Characterisation of cobalt/copper multilayers obtained by electrodeposition 显示文摘 | GOMEZ E LALARTA A LLORENTE A VALLES E | 2002 | Surface and Coatings Technology2002，153，23： | 1 |
| 16 | Impacts of land use conflicts on riverine ecosystems 显示文摘 | Renato F Valle Junior Simone G P Varandas Femando A L Pacheco | 2014 | Land Use Policy2014，43，： | 1 |
| 17 | Mierostructural evolution during large strain hot rolling of an AM60 alloy 显示文摘 | PEREZ - PRADO M T VALLE J A CONTRERAS J M RUANOO A | 2004 | Scripta Mater2004，50，5： | 1 |
| 18 | Dual-phase helical CT of pancreatic adenocarcinoma:assessment of resectability before surgery显示文摘 | Valls C Andia E Sanchez A | 2002 | AJR2002，178，4： | 1 |
| 19 | Cytogenetics of six natural and introduced genotypes of Hemarthria altissima (Poiret) Stapf & Hubbard (Gramineae)显示文摘 | Tedesco S B Battistin A Valls J F M | 1998 | Ciencia Rural1998，28，2： | 1 |
| 20 | Detection of equine arteritis virus in semen by reverse transcriptase polymerase chain reaction-ELISA显示文摘 | Ramina A Dalla Valle L De Mas S | 1999 | Comp Immunol Microbiol Infect Dis 22:187-1971999，，： | 1 |
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