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| 1 | Essential hypertension and oxidative stress:New insights显示文摘Essential hypertension is a highly prevalent pathological condition that is considered as one of the most relevant cardiovascular risk factors and is an important cause of morbidity and mortality around the world. Despite the fact that mechanisms underlying hypertension are not yet fully elucidated,a large amount of evidence shows that oxidative stress plays a central role in its pathophysiology. Oxidative stress can be defined as an imbalance between oxidant agents,such as superoxide anion,and antioxidant molecules,and leads to a decrease in nitric oxide bioavailability,which is the main factor responsible for maintaining the vascular tone. Several vasoconstrictor peptides,such as angiotensin Ⅱ,endothelin-1 and urotensin Ⅱ,act through their receptors to stimulate the production of reactive oxygen species,by activating enzymes like NADPH oxidase andxanthine oxidase. The knowledge of the mechanism described above has allowed generating new therapeutic strategies against hypertension based on the use of antioxidants agents,including vitamin C and E,N-Acetylcysteine,polyphenols and selenium,among others. These substances have different therapeutic targets,but all represent antioxidant reinforcement. Several clinical trials using antioxidants have been made. The aim of the present review is to provide new insights about the key role of oxidative stress in the pathophysiology of essential hypertension and new clinical attempts to demonstrate the usefulness of antioxidant therapy in the treatment of hypertension. | Jaime González Nicolás Valls Roberto Brito Ramón Rodrigo | 2014 | World Journal of Cardiology2014，6，6： | 20 |
| 2 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 3 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 4 | Antiviral activity of maca ( Lepidium meyenii ) against human influenza virus显示文摘 | Juana del Valle Mendoza Tomàs Pumarola Libertad Alzamora Gonzales Luis J. del Valle | 2014 | Asian Pacific Journal of Tropical Medicine2014，，： | 3 |
| 5 | ECG Criteria to Identify Epicardial Ventricular Tachycardia in Nonischemic Cardiomyopathy显示文摘 | Ermengol Vallès Victor Bazan Francis E. Marchlinski | 2010 | Circulation: Arrhythmia and Electrophysiology2010，，1： | 2 |
| 6 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 7 | Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients显示文摘 | Francesc Vallribera Valls Filippo Landi Eloy Espín Basany José Luis Sánchez García Luis Miguel Jiménez Gómez Marc Martí Gallostra Luis Salgado Cruz Manuel Armengol Carrasco | 2014 | Surgical Endoscopy2014，，12： | 2 |
| 8 | Justification and RCPSP:a technique that pays显示文摘 | VALLS V BALLESTIN F QUINTANILLA S | 2005 | European Journal of Operational Research2005，165，2： | 1 |
| 9 | Carboxylamidase activity in the fall armyworm (Lepidoptera:Noctuidae) and other lepidoptera,orthoptera and dictyoptera显示文摘 | YU S J VALLES S M | 1997 | J Econ Entomol1997，90，6： | 1 |
| 10 | Dental infections and coronary atherosclerosis 显示文摘 | Mattila K J Valle M S Nieminen M S | 1993 | Athemsclerosis1993，103，2： | 1 |
| 11 | HIV disorders of the brain patholo- gy and pathogenesis显示文摘 | Del Valle L Piria Oviedo S | 2006 | Front Biosei2006，1，11： | 1 |
| 12 | Recursive PCA for adaptive process monitoring 显示文摘 | Li W Yue H Valle S and Qin S J | 2000 | 10 ( 1 ) :471-4862000，10，1： | 1 |
| 13 | Relation between the presence of inhibitors and deposit morphology in nickel deposition 显示文摘 | VALLéS E POLLINA R GóMEZ E | 1993 | Journal of Applied Electrochemistry1993，23，5： | 1 |
| 14 | Cytogenetics of six natural and introduced genotypes of Hemarthria altissima (Poiret) Stapf & Hubbard (Gramineae)显示文摘 | Tedesco S B Battistin A Valls J F M | 1998 | Ciencia Rural1998，28，2： | 1 |
| 15 | Detection of equine arteritis virus in semen by reverse transcriptase polymerase chain reaction-ELISA显示文摘 | Ramina A Dalla Valle L De Mas S | 1999 | Comp Immunol Microbiol Infect Dis 22:187-1971999，，： | 1 |
| 16 | The human p19ARF protein encoded by the β transcrip t of the p16 INK4A gene is frequently lost in non - small cell lung cancer显示文摘 | Gazzeri S Della Valle V Chaussade L | 1998 | Cancer Res1998，58，17： | 1 |
| 17 | Preparation of MoS2 and WS2 catalysts by in situ decomposition of ammonium thiosalts显示文摘 | Alonso G Del Valle M Cruz J Petranovskii V LiceaClaverie A Fuentes S | | 0，，： | 1 |
| 18 | MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster 显示文摘 | Xu S Witmer PD Lumayag S Kovacs B Valle D | 2007 | J Biol Chem2007，282，25： | 1 |
| 19 | Particle swarm optimization: basic concepts, variants and ap- plications in power systems 显示文摘 | del VALLE Y VENAYAGAMOORTHY G K MOHAGHEGHI S | 2008 | IEEE Transactions on Evolutionary Comoutation2008，12，2： | 1 |
| 20 | Chitosan as a potential natural compound to control pre and post - harvest diseases of horticultural commodities显示文摘 | Bautista - Banos S Hemandez - Lauzardo A N Velazquez - del Valle M G | 2006 | Crop Pro- tection2006，25，2： | 1 |
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