|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Justification and RCPSP:a technique that pays显示文摘 | VALLS V BALLESTIN F QUINTANILLA S | 2005 | European Journal of Operational Research2005，165，2： | 1 |
| 3 | Extraction-atomic absorption method for the determination of arsenic,antimony,selenium and tellurium in geologic samples显示文摘 | Togov V G Vall G A Demidova M G | 1995 | Chem Geol1995，124，： | 1 |
| 4 | The human p19ARF protein encoded by the β transcrip t of the p16 INK4A gene is frequently lost in non - small cell lung cancer显示文摘 | Gazzeri S Della Valle V Chaussade L | 1998 | Cancer Res1998，58，17： | 1 |
| 5 | Preparation of MoS2 and WS2 catalysts by in situ decomposition of ammonium thiosalts显示文摘 | Alonso G Del Valle M Cruz J Petranovskii V LiceaClaverie A Fuentes S | | 0，，： | 1 |
| 6 | Optimization of an equilibrium modified atmosphere packaging(Emap)for minimally processed mandarin segments显示文摘 | Valle V Hernández-Mu?oz P Catalá R | | 0，，03： | 1 |
| 7 | Radiofrequency ablation of hepatic tumors 显示文摘 | Valls C Ruiz S Barrau V | 2006 | Radiology2006，48，2： | 1 |
| 8 | Study of the quality of life in people with traumatic spinal cord injury显示文摘 | VALL J BRAGA V A DE ALMEIDA P C | 2006 | Arquivos de Neuro-Psiquiatria2006，64，2： | 1 |
| 9 | Resource-constrained project scheduling:a critical activity reordering heuristic显示文摘 | VALLS V QUINTANILLA S BALLESTIN F | 2003 | European Journal of Operational Research2003，149，2： | 1 |
| 10 | Justification and RCPSP: A technique that pays显示文摘 | VALLS V BALLESTIN F QUINTANILLA S | 2005 | European Journal of Operational Research2005，165，2： | 1 |
| 11 | Pre-emption in resource-constrained project scheduling显示文摘 | BALLESTIN F VALLS V QUINTANILLA S | 2008 | European Journal of Operational Research2008，189，3： | 1 |
| 12 | Mutation in TET2 in myeloid cancers显示文摘 | Delhommeau F Dupont S Della Valle V | | 0，，22： | 1 |
| 13 | Role of oxidative stress and molecular changes in liver fibrosis : a review显示文摘 | SANCHEZ VALLE V CHAVEZ TAPIA N C URIBE M | 2012 | Curt Med Chem2012，19，28： | 1 |
| 14 | Scaling up post-abortion care in Guatemala:initial successes at national level显示文摘 | KESTLER E VALENCIA L DEL VALLE V | 2006 | Reprod Health Matters2006，14，27： | 1 |
| 15 | Effec- tiveness and pharmaceutical cost of sequential treatment for Helicobacter pylori in patients with non-ulcer dyspep- sia显示文摘 | De Francesco V Della Valle N Stoppino V | 2004 | Aliment Pharmacol Ther2004，19，9： | 1 |
| 16 | A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia显示文摘 | Lacronique V Boureux A Valle VD | 1997 | Science1997，278，： | 1 |
| 17 | Justifica- tion and RCPSP:a technique that pays显示文摘 | VALLS V BALLESTIIN F QUINTANILLA S | 2005 | European Journal of Operational Research2005，165，2： | 1 |
| 18 | A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia显示文摘 | Lacrpnoqie V Boureux A Valle VD | 1997 | Science1997，278，5341： | 1 |
| 19 | Grafting of N-carbamyl maleamic acid onto a styrene-butadiene-styrene copolymer显示文摘 | Lassalle V L Failla M D Valles E M | 2006 | Appl Polym Sci2006，102，5： | 1 |
| 20 | MLH1 germline epimutations in selected patients with early-onset non-polyposis colorectal cancer 显示文摘 | Valle L Carbonell P Fernandez V | 2007 | Clin Genet2007，71，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员