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| 1 | Continuous-Time Models for Firm Valuation and Their Collateral Effect on Risk-Neutral Probabilities and No-Arbitraging Principle显示文摘Extensions of Merton’s model(EMM)considering the firm’s payments and generating new types of firm value distribution are suggested.In the open log-value/time space,these distributions evolve from initially normal to negatively skewed ones,and their means are concave-down functions of time.When payments are set to zero or proportional to the firm value,EMM turns into the Geometric Brownian model(GBM).We show that risk-neutral probabilities(RNPs)and the no-arbitraging principle(NAP)follow from GBM.When firm’s payments are considered,RNPs and NAP hold for the entire market for short times only,but for long-term investments,RNPs and NAP just temporarily hold for individual stocks as far as mean year returns of the firms issuing those stocks remain constant,and fail when the mean year returns decline.The developed method is applied to firm valuation to derive continuous-time equations for the firm present value and project NPV. | Valery V Shemetov | 2020 | Management Studies2020，8，3： | 3 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening显示文摘Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed. | Ekaterina I Galanzha Valery V Tuchin Vladimir P Zharov | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 4 | A new sono-electrochemical method for enhanced detoxification of hydrophilic chloroorganic pollutants in water显示文摘 | Yakov Y Valery B Vladimir V G | 2004 | Ultrasonics Sonochemistry2004，11，： | 1 |
| 5 | Mathematical model of a loop heat pipe with cylindrical evaporator and integrated reservoir显示文摘 | Valeri V V Roger R R | 2008 | Applied Thermal Engineering2008，28，89： | 1 |
| 6 | Monte-Carlo simulation of light propagation in a multi-layered biological tissue with optical clearing显示文摘 | EUGENHY P SAVCHENKO VALERY V | 2000 | SPIE2000，4162，： | 1 |
| 7 | A stepwise Huisgen cycloaddition process:Copper(Ⅰ)-catalyzed regioselective ligation of azides and terminal alkynes显示文摘 | Vsevolod V R Luke G G Valery V F | | 0，，14： | 1 |
| 8 | Challenges in the Detection and Attribution of Northern Hemisphere Surface Temperature Trends Since 1850显示文摘Since 2007,the Intergovernmental Panel on Climate Change(IPCC)has heavily relied on the comparison between global climate model hindcasts and global surface temperature(ST)estimates for concluding that post-1950s global warming is mostly human-caused.In Connolly et al.,we cautioned that this approach to the detection and attribution of climate change was highly dependent on the choice of Total Solar Irradiance(TSI)and ST data sets.We compiled 16 TSI and five ST data sets and found by altering the choice of TSI or ST,one could(prematurely)conclude anything from the warming being“mostly human-caused”to“mostly natural.”Richardson and Benestad suggested our analysis was“erroneous”and“flawed”because we did not use a multilinear regression.They argued that applying a multilinear regression to one of the five ST series re-affirmed the IPCC's attribution statement.They also objected that many of the published TSI data sets were out-of-date.However,here we show that when applying multilinear regression analysis to an expanded and updated data set of 27 TSI series,the original conclusions of Connolly et al.are confirmed for all five ST data sets.Therefore,it is still unclear whether the observed warming is mostly human-caused,mostly natural or some combination of both. | Ronan Connolly Willie Soon Michael Connolly Sallie Baliunas Johan Berglund C.J.Butler Rodolfo Gustavo Cionco Ana G.Elias Valery M.Fedorov Hermann Harde Gregory W.Henry Douglas V.Hoyt Ole Humlum David R.Legates Nicola Scafetta Jan-Erik Solheim LászlóSzarka Víctor M.Velasco Herrera Hong Yan Weijia Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，10： | 1 |
| 9 | Multiple-Sensor People Localization in an Office Environment显示文摘 | Gang Wei Valery A Petrushin Anatole V Gershman | 2007 | Multimedia Data Mining and Knowledge Discovery2007，，： | 1 |
| 10 | Cellular focal segmental glomerulosclerosis: clinical and pathologic features显示文摘 | Stokes M B Valeri A M Markowitz G S D'Agati V D | 2006 | Kidney Int2006，70，： | 1 |
| 11 | Pluronic block copolymers for overcoming drug resistance in cancer 显示文摘 | ALEXANDER V K ELENA V B VALERY Y A | 2002 | Adv Drug Deliv Rev2002，54，5： | 1 |
| 12 | The detection of some dicarbonyl intermediates arising from the degradation of Amadori compounds ( the Maillard reaction ) 显示文摘 | Jan Hirsch Valeri V Mossine Milton S | 1995 | Feather Carbohydrate Research1995，273，2： | 1 |
| 13 | Mesenchymal Stem Cell Adhesion and Spreading on Microwave Plasma-Nitrided Titanium Alloy显示文摘 | Clem William C Konovalov Valery V Chowdhury S | 2005 | Wiley Periodicals2005，76，： | 1 |
| 14 | 显示文摘 | Vladimir V D Valerie C M David S B | 2005 | Nano Lett2005，5，81： | 1 |
| 15 | Epigallocatechin (EGC) of green tea induces apoptosls of haman breast cancer cells but not of there normal countreparts 显示文摘 | David V Cecile C O Valerie C | 2002 | Breast Cancer Research and Treat- ment2002，76，： | 1 |
| 16 | Optimization of MO Bragg diffraction of guided optical waves by MSW in YIG films by using inclined bias field 显示文摘 | Kolokoltsev O V Valeri Vountesmeri | 2001 | J Magn Magn Mater2001，225，： | 1 |
| 17 | Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer显示文摘 | Valerie R David K Ennapadam V | 1995 | Cancer Res1995，55，21： | 1 |
| 18 | Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer显示文摘 | Valerie R David K Ennapadam V | 1995 | Cancer Res1995，55，21： | 1 |
| 19 | The vitamin E analog tocopherol succinate strongly inhibits gap junctional intercellular communication in rat liver epithelial ceils ( IAR203 ) 显示文摘 | Catherine C Valerie B Frederic V | 2008 | J Nutr Biochem2008，19，4： | 1 |
| 20 | One-step synthe- sis of TiOz (B) nanoparticles from a water-soluble titanium complex 显示文摘 | Makoto K Valery V P Masato K | 2007 | Chem Mater2007，19，： | 1 |
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