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| 1 | SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients显示文摘BACKGROUND Colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of 2018.It affects 1.2 million people around the world and is responsible for about 0.6 million deaths every year.Despite decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(<50 years).Patients are often diagnosed at late stages of the disease and tend to have poor survival.We previously showed that the WNT“gatekeeper”gene,secreted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon cancer.SFRP4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient survival.METHODS SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of California Santa Cruz Cancer Browser interface.RESULTS SFRP4 was found to be co-expressed with the EMT-linked markers CDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and COL1A1.SFRP4 expression negatively correlated with the EMTlinked suppressors CLDN4,CLDN7,TJP3,MUC1,and CDH1.The expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon cancer.Additionally,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).CONCLUSION Considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy. | Landry E Nfonsam Jana Jandova Hunter C Jecius Pamela N Omesiete Valentine N Nfonsam | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 4 |
| 2 | The effect of flutamide on the physical working capacity and activity of some of the key enzymes for the energy supply in adult rats显示文摘学习的目的是在老鼠为精力供应在一些关键肌肉酶的物理工作能力和活动上估计雄激素受体对手的效果。年轻成年男 Wistar 老鼠被划分成二个组。一个组一个星期和作为控制为服务 8 个星期的另外的组每天收到了 flutamide 的 15 mg kg-1 6 天。在开始并且在实验的结束,所有老鼠受到 submaximal 跑耐力(SRE ) ,疲劳(MTE ) 的最大的时间,和最大的疾跑速度(女士) 测试。在试用的结束,最大的氧消费(VO2max ) 测试被执行并且睾丸激素,红血球,血红素以及 succinate 脱氢酶(同步数字系列) 的酶活动的层次,喂奶脱氢酶(LDH ) ,和 gastrocnemius 肌肉的 NAD.H2-cytochrome-c reductase (NAD.H2 ) 被测量。对待 flutamide 的老鼠的浆液睾丸激素比控制的高,它验证选择的剂量的有效性。anti-androgen-treated 组的 MTE 和 SRE 与起始的价值相比是更低的。Flutamide 处理减少了同步数字系列和 NAD.H2 的活动与控制相比。我们没在女士, VO2max,跑的经济, LDH 活动,和 hematological 变量上发现反雄激素处理的效果。我们的调查结果显示象一些关键酶的活动一样的 submaximal 和最大的跑耐力的维护把氧化能力与肌肉联系了与雄激素效果被连接由雄激素受体调停了。 | Katerina N Georgieva Penka A Angelova Fani D Gerginska Dora D Terzieva Mihaela S Shishmanova-Doseva Slavi D Delchev Valentine V Vasilev | 2017 | Asian Journal of Andrology2017，19，4： | 2 |
| 3 | Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin′s lymphoma显示文摘 | Morris S W Kirstein M N Valentine M B | 1994 | Science1994，263，5151： | 1 |
| 4 | Carbon nanotubes: Properties and application 显示文摘 | Valentin N P | 2004 | Materials Science and Engineering2004，43，3： | 1 |
| 5 | Surface structure of stainless and Hadfield steel after impact显示文摘 | Yuri N Petrov Valentin G Gavriljuk Hans Berns | 2006 | Wear2006，260，6： | 1 |
| 6 | Visualisation ofneuroblastoma growth in a Scid mouse model using FDG and FLT - PET显示文摘 | Krieger - Hinck N Gustke H Valentiner U | 2006 | Anticancer Res2006，26，5： | 1 |
| 7 | Effect of culture conditions on microorganism identification by matrix-assisted laser desorption ionization mass spectrometry显示文摘 | Valentine N Wunschel S Wunschel D | | 0，，01： | 1 |
| 8 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet . 2004 (9435)2004，，9435： | 1 |
| 9 | AMPK activation: a therapeutic target for type 2 diabetes?显示文摘 | Coughlan K A Valentine R J Ruderman N B | 2014 | Diabetes Metab Syndr Obes2014，24，7： | 1 |
| 10 | Free sterol compositions from the sea cucumbers Pseudostichopus tra- chus , Holothuria (Microtele) nobilis , Holothuria scabra, Trochos- toma orientale and Bathyplotes natans 显示文摘 | VALENTINE A S LJUDMILA P P TATIANA N M | 1998 | Comp Biochem Phys B1998，120，2： | 1 |
| 11 | Human platelet alloantigens:recent findings,new perspectives显示文摘 | Newman PJ Valentin N | 1999 | Thromb Haemost1999，74，： | 1 |
| 12 | Effects of bortezomib on human neuroblastoma cells in vitro and in a metastatic xenograft model 显示文摘 | Valentiner U Haane C Nehmann N | 2009 | Anticancer Res2009，29，4： | 1 |
| 13 | Crossover/non-crossover dif- ferentiation, synaptonemal complex formation, and regulatory surveil- lance at the leptotene/zygotene transition of meiosis显示文摘 | Valentin B G Kleckner N Hunter N | 2004 | Cell2004，117，1： | 1 |
| 14 | Cost-effectiveness of the addition of acarbose to the treatment of patients with type-2 diabetes in Spain显示文摘 | Pi(n)ol C Roze S Valentine W | 2007 | Gac Sanit2007，21，2： | 1 |
| 15 | Surface Structure of Stainless and Hadfield Steel after Impact Wear显示文摘 | Yuri N P Valentin G G Hans B | 2006 | Wear2006，260，6： | 1 |
| 16 | AMPK activation a therapeutic target for type 2 diabetes?显示文摘 | Coughlan K A Valentine R J Ruden'nan N 13 | 2014 | Diabetes Metab Syndr Obes2014，7，： | 1 |
| 17 | Highly efficient transient expression of functional recombinant antibodies in lettuce 显示文摘 | VALENTINE N GALINA E HYUNG-il L | 2005 | Plant Science2005，169，： | 1 |
| 18 | Effect of culture conditions on microorganism identification by matrix-assisted laser desorption ionization mass spectrometry 显示文摘 | VALENTINE N WUNSCHEL S WUNSCHEL D | 2005 | Appl Environ Microbiol2005，71，1： | 1 |
| 19 | Limits of the Turbine Efficiency for Free Fluid Flow 显示文摘 | Alexander N Gorban Alexander M Gorlov Valentin M Silantyev | 2001 | Energy Resources Technology2001，，123： | 1 |
| 20 | Thermal shock resistance of SiC-BN composites显示文摘 | P G Valentine A N Palazotto R Ruh | 1986 | Advanced Ceramic Materials1986，1，1： | 1 |
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