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| 1 | 不同含水量亚黏土的崩解特性实验研究显示文摘为了分析土的初始含水量与其崩解性的相关关系,选取了一种高孔隙率、粉黏粒含量较高,且不具有湿陷性的轻质亚黏土作为研究对象。对7组不同含水量的土样品进行崩解试验,发现随着初始含水量的增大,其崩解时间越长,初始含水量接近于风干含水量的土样品能够完全崩解,当初始含水量为天然含水量时,土样品崩解的过程是由'内'到'外',由整体崩解为大块,然后再崩解为更小的块状;当初始含水量为风干含水量时,土样品崩解过程是由'外'到'内'以鳞片状一层一层地崩解;随着土样初始含水量的增大其崩解速率逐渐变小,初始含水量接近风干含水量时,土样在完全崩解的过程中,其崩解敏感性较强;初始含水量接近天然含水量的情况下,在不完全崩解的过程中,其崩解敏感性较弱。 | 张泽 马巍 PENDIN Vadim V 张中琼 何瑞霞 | 2014 | 水文地质工程地质2014，41，4： | 11 |
| 2 | Risk factors and urinary biomarkers of non-albuminuric and albuminuric chronic kidney disease in patients with type 2 diabetes显示文摘BACKGROUND A number of recent studies indicate a transformation in the natural course of chronic kidney disease(CKD)in type 2 diabetes(T2D)patients:an increasing prevalence of declined renal function without proceeding to the accompanying elevation of albuminuria.It has been suggested that albuminuric and nonalbuminuric CKD patterns could be different in their phenotypes and pathogenic mechanisms.AIM To identify the risk factors and biomarkers of albuminuric and non-albuminuric patterns of CKD in patients with T2D.METHODS Three hundred sixty patients with T2D duration≥10 years were included in this observational cross-sectional study.The associations of a panel of demographic and clinical characteristics,complications,comorbidities,and metabolic and hematology parameters with albuminuric and non-albuminuric CKD patterns were analyzed.The urinary excretion of nephrin and podocin,two podocytespecific markers,and WAP-four-disulfide core domain protein 2(WFDC-2),a marker of tubulointerstitial fibrosis,was determined by ELISA in comparison with healthy controls.RESULTS Non-albuminuric CKD was associated with age≥65 years(P=0.0001),female sex(P=0.04),diabetes duration≥15 years(P=0.0009),and the use of diuretics(P=0.0005).Male sex(P=0.01),smoking(P=0.01),waist-to-hip ratio>1.0(P=0.01)and hemoglobin A1c(HbA1c)>8.0%(P=0.005)were risk factors for elevated albuminuria not accompanied by a decrease in estimated glomerular filtration rate(eGFR).Duration of diabetes≥15 years and the use of calcium channel blockers were risk factors for albuminuria with decreased eGFR(both P=0.01).In multivariate logistic regression analysis,age,HbA1c,female sex and diuretics were significant predictors for reduced eGFR,while waist-to-hip ratio,HbA1c and male sex were associated with elevated urinary albumin-to-creatinine ratio(UACR).Excretion of nephrin and podocin was increased in patients with albuminuria,regardless of decline in renal function(P<0.001),correlating positively with UACR.The urinary excretion of WFDC-2 was markedly higher in men than in women(P<0.000001).Men with T2D demonstrated increased WFDC-2 levels independently of the CKD pattern(all P<0.05).In T2D women,WFDC-2 excretion was increased in those with reduced renal function(P≤0.01),correlating negatively with eGFR.CONCLUSION The data provide further evidence that albuminuric and non-albuminuric CKD phenotypes correspond to different pathways of diabetic kidney disease progression. | Anton I Korbut Vadim V Klimontov Ilya V Vinogradov Vyacheslav V Romanov | 2019 | World Journal of Diabetes2019，10，11： | 3 |
| 3 | SPH-BEM simulation of underwater explosion and bubble dynamics near rigid wall显示文摘A process of underwater explosion of a charge near a rigid wall includes three main stages: charge detonation, bubble pulsation and jet formation. A smoothed particle hydrodynamics(SPH) method has natural advantages in solving problems with large deformations and is suitable for simulation of processes of charge detonation and jet formation. On the other hand, a boundary element method(BEM) is highly efficient for modelling of the bubble pulsation process. In this paper, a hybrid algorithm, fully utilizing advantages of both SPH and BEM, was applied to simulate the entire process of free and near-field underwater explosions. First, a numerical model of the free-field underwater explosion was developed, and the entire explosion process–from the charge detonation to the jet formation–was analysed. Second, the obtained numerical results were compared with the original experimental data in order to verify the validity of the presented method. Third, a SPH model of underwater explosion for a column charge near a rigid wall was developed to simulate the detonation process. The results for propagation of a shock wave are in good accordance with the physical observations. After that, the SPH results were employed as initial conditions for the BEM to simulate the bubble pulsation. The obtained numerical results show that the bubble expanded at first and then shrunk due to a differences of pressure levels inside and outside it. Here, a good agreement between the numerical and experimental results for the shapes, the maximum radius and the movement of the bubble proved the effectiveness of the developed numerical model. Finally, the BEM results for a stage when an initial jet was formed were used as initial conditions for the SPH method to simulate the process of jet formation and its impact on the rigid wall. The numerical results agreed well with the experimental data, verifying the feasibility and suitability of the hybrid algorithm. Besides, the results show that, due to the effect of the Bjerknes force, a jet with a high speed was formed that may cause local damage to underwater structures. | ZHANG ZhiFan WANG Cheng ZHANG A-Man Silberschmidt Vadim V WANG LongKan | 2019 | Science China(Technological Sciences)2019，62，7： | 3 |
| 4 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 5 | Linagliptin alleviates fatty liver disease in diabetic db/db mice显示文摘AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(BKS.Cg-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, P = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independent to changes in the plasma glucose levels. CONCLUSION The DPP4 inhibitor linagliptin alleviates liver steatosis and structural changes in the hepatic microvasculature and lymphatic roots in a model of NAFLD in diabetic db/db mice. | Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova Eugenii L Zavjalov Galina V Koncevaya Vladimir I Konenkov | 2016 | World Journal of Diabetes2016，7，19： | 2 |
| 6 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 7 | The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response显示文摘像使用费的受体(TLR ) 7 和 8 在对搁浅单人赛的 RNA (ssRNA ) 病毒的主人防卫是关键的。如此的病毒引起严重的病,它在 industrialised 和发展中的国家仍然是严肃的医药负担。下游地发信号的 TLR7/8 导致与精力消费联系的一个戏剧的细胞的压力。然而,到 TLR7/8-induced 应力的房间幸存和改编的分子的机制,给房间一个机会开始合适的煽动性的反应,根本不是清楚的。这里,我们第一次报导 TLR7/8 的导致 ligand 的激活导致组织缺氧可诱导的因素的累积 1 alpha (在经由氧化还原作用的 THP-1 人的 myeloid 巨噬细胞的 HIF-1 伪) 蛋白质 -- 并且反应的氮种类依赖者机制。地图 kinases 和 phosphoinositol-3K 不涉及 TLR7/8-mediated HIF-1 伪累积。有击倒的 THP-1 房间清楚地表明了的 HIF-1 伪的实验那 HIF-1 伪为对 ATP 的 TLR7/8-induced 弄空的这些房间的保护是重要的。因此, HIF-1 伪可能在 TLR7/8 激活之上支持房间幸存和支持 inflammatory cytokines 的生产。 | Sally A Nicholas Vadim V Sumbayev | 2009 | Cell Research2009，19，8： | 2 |
| 8 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 9 | Recent developments in catalysis using nano-structured materials 显示文摘 | N Raveendran Shiju Vadim V Guliants | 2009 | Applied Catalysis A2009，3，6： | 1 |
| 10 | High-throughput experimentation in multicomponent bulk mixed metal oxides: Mo-V-Sb-Nb-O system for selective oxidation of propane to acrylic acid 显示文摘 | JAMAL N Al-SAEEDI VADIM V G | 2002 | Applied Catalysis A: General2002，237，12： | 1 |
| 11 | Cutting forces in ultrasonically assisted drilling of carbon fibre-reinforced plastics显示文摘 | Farrukh Makhdum Luke T Jennings Anish Roy Vadim V Silberschmidt | 2012 | Journal of Physics: Conference Series2012，，1： | 1 |
| 12 | Optimal control of cooling process in continuous casting of steel u- sing a visualization based multi-criteria approach 显示文摘 | ALEXANDER V GEROGE K VADIM E | 2005 | Ap- plied Mathematical Modelling2005，29，7： | 1 |
| 13 | Multiracial characteristics of matrix cracking in laminates under T-fatigue显示文摘 | Vadim V S | 1998 | Computational materials science1998，13，： | 1 |
| 14 | Laser diodes emitting up to 25 W at 808 nm显示文摘 | V V Bezotosnyi Vadim Yu Bondarev Oleg N Krokhin G T Mikaelyan V A Oleshchenko Valerii F Pevtsov Yurii M Popov E A Cheshev | 2009 | Quantum Electronics2009，，3： | 1 |
| 15 | Modeling of Gaussian beam diffration on volume Bragg gratings in PTR glass 显示文摘 | Ciapurin Igor V Glebov Leonid B Smimov Vadim I | 2005 | SPIE2005，5742，： | 1 |
| 16 | Recent developments in catalysis using nano - structured materials 显示文摘 | Raveendran N Shiju Vadim V | 2009 | Applied Catalysis A :2009，3，6： | 1 |
| 17 | Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography evaluation of subcutaneous panniculitis-like T cell lymphoma and treatment response显示文摘Subcutaneous panniculitis-like T cell lymphoma(SPTCL) is a very rare variant of non-Hodgkin's lymphoma. Currently, there is no standard imaging method for staging of SPTCL nor for assessment of treatment response. Here, we describe our use of fluorine-18 fluorodeoxyglucose(FDG) positron emission tomography/computed tomography(PET/CT) for staging and monitoring of treatment response in 3 cases of SPTCL. Primary staging by PET/CT showed that all 3 patients had multiple foci in the subcutaneous fat tissue, with SUVmax from 10.5 to 14.6. Involvement of intra-abdominal fat with high SUVmax was identified in 2 of the patients. Use of the triple drug regimen of gemcitabine, cisplatin and methylprednisolone(commonly known as 'GEM-P') as first-line therapy or second-line therapy facilitated complete metabolic response for all 3 cases. FDG PET/CT provides valuable information for staging and monitoring of treatment response and can reveal occult involvement of the intraabdominal visceral fat. High FDG uptake on pre-treatment PET can identify patients with aggressive disease and help in selection of first-line therapy. | Vadim R Gorodetskiy Olga V Mukhortova Irakli P Aslanidis Wolfram Klapper Natalya A Probatova | 2016 | World Journal of Clinical Cases2016，4，9： | 1 |
| 18 | Direct measurement of spectral phase for ultrashort laserpulses显示文摘 | VADIM V LOZOVOY BINGWEI XU YVES COELLO | | 0，，02： | 1 |
| 19 | : Redefining the scope of the federal trademark dilution 显示文摘 | Vadim Vapnyar Mosely v V Secret Catalogue inc | 2003 | Saint John''s Law Review Summer 679 (2003，2003，： | 1 |
| 20 | Tailoring pore properties of MCM-48silica for selective adsorption of CO2显示文摘 | Kim S Ida J Vadim V G | 2005 | Journal of Physical Chemistry B2005，109，13： | 1 |
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