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| 1 | Diabetic retinopathy-ocular complications of diabetes mellitus显示文摘In industrialized nations diabetic retinopathy is the most frequent microvascular complication of diabetes mellitus and the most common cause of blindness in the workingage population.In the next 15 years,the number of patients suffering from diabetes mellitus is expected to increase significantly.By the year 2030,about 440 million people in the age-group 20-79 years are estimated to be suffering from diabetes mellitus worldwide(prevalence 7.7%),while in 2010 there were 285 million people with diabetes mellitus(prevalence 6.4%).This accounts for an increase in patients with diabetes in industrializednations by 20% and in developing countries by 69% until the year 2030.Due to the expected rise in diabetic patients,the need for ophthalmic care of patients(i.e.,exams and treatments) will also increase and represents a challenge for eye-care providers.Development of optimized screening programs,which respect available resources of the ophthalmic infrastructure,will become even more important.Main reasons for loss of vision in patients with diabetes mellitus are diabetic macular edema and proliferative diabetic retinopathy.Incidence or progression of these potentially blinding complications can be greatly reduced by adequate control of blood glucose and blood pressure levels.Additionally,regular ophthalmic exams are mandatory for detecting ocular complications and initiating treatments such as laser photocoagulation in case of clinical significant diabetic macular edema or early proliferative diabetic retinopathy.In this way,the risk of blindness can considerably be reduced.In advanced stages of diabetic retinopathy,pars-plana vitrectomy is performed to treat vitreous hemorrhage and tractional retinal detachment.In recent years,the advent of intravitreal medication has improved therapeutic options for patients with advanced diabetic macular edema. | Martin M Nentwich Michael W Ulbig | 2015 | World Journal of Diabetes2015，6，3： | 44 |
| 2 | Structure-function relationship comparison between retinal nerve fibre layer and Bruch's membrane opening-minimum rim width in glaucoma显示文摘AIM:To evaluate and compare structural optical coherence tomography(OCT)-based parameters,such as Bruch's membrane opening-minimum rim width(BMO-MRW),and retinal nerve fiber layer(RNFL) thickness in glaucoma patients with visual field(VF) defects,and to correlate both to mean deviation(MD) values of obtained standard achromatic perimetry(SAP) examinations.METHODS:Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals.All study participants underwent a full ophthalmic examination and VF testing with SAP.Peripapillary RNFL thickness and BMO-MRW were acquired with SD-OCT.Correlation analyses between obtained global functional and global as well as sectorial structural parameters were calculated.RESULTS:A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36 healthy right eyes of 36 individuals in the control group.Global MD of values correlated significantly with global RNFL(Pearson corr.coeff:0.632,P=0.001) and global BMO-MRW(Pearson corr.coeff:0.746,P<0.001) values in the glaucoma group.Global MD and sectorial RNFL or BMO-MRW values correlated less significantly.In the control group,MD values did not correlate with RNFL or BMO-MRW measurements.A subgroup analysis of myopic patients(>4 diopters) within the glaucoma group(n=6) revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL measurements.CONCLUSION:In a clinical setting,RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients. | Lukas Reznicek Sophie Burzer Andrea Laubichler Ali Nasseri Chris P Lohmann Nikolaus Feucht Michael Ulbig Mathias Maier | 2017 | International Journal of Ophthalmology(English edition)2017，10，10： | 2 |
| 3 | Correlation of leaking microaneurysms with retinal thickening in diabetic retinopathy显示文摘AIM: To investigate the contribution of fluorescein angiographic leaking microaneurysms (leak-MA) versus non-leaking microaneurysms (non-leak-MA) to retinal thickening in diabetic retinopathy.METHODS: A consecutive series of 38 eyes from 24 patients with diabetic retinopathy was included.Leak-MA and non-leak-MA in each eye were selected in pairs at corresponding topographic location.Leaking was defined by late phase fluorescein angiograms compared to early phase.Retinal thickness was measured with Heidelberg Spectralis OCT topographically aligned on early phase angiograms at the MA site and within a 1 mm circle.RESULTS: In all eyes,significant retinal thickening at the site of leaking compared to non-leaking microaneurysms was observed (356±69μm vs 318±56μm,P <0.001),showing a mean increase in thickness in the areas of leak-MA vs non-leak-MA of 38±39μm (95% confidence interval 2551μm,P<0.001).All 1mm area measurements also showed significant (P<0.001) thickening of the leak-MA with average thickness of leak-MA vs non-leak-MA as 351±67μmvs 319±59μm;minimum thickness 311±62μm vs 284±60μm;maximum thickness 389±78μm vs 352±66μm;and retina volume 26.4±6.0mmvs 23.6±3.7mm3,respectively.CONCLUSION: Leaking of microaneurysms on fluorescein angiography appears to cause focal thickening of retina,which can be measured with high-resolution OCT.Therefore,targeting leaking microaneursyms in diabetic retinopathy has the potential to reduce retinal thickening. | Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 2 |
| 4 | Comparison of Intravitreal Bevacizumab versus Triamcinolone for the Treatment of Diffuse Diabetic Macular Edema显示文摘 | Kreutzer Thomas C Al Saeidi Rashid Kook Daniel Wolf Armin Ulbig Michael W Neubauer Aljoscha S Haritoglou Christos | 2010 | Ophthalmologica2010，，4： | 2 |
| 5 | Laser treatment in dia- betic retinopathy显示文摘 | A1Joscha S Neubauer Micheal W Ulbig | 2007 | Ophthalmologica2007，221，： | 1 |
| 6 | Resolution of diabetic maeular edema after surgical removal of the posterior hyaloids and the inner limiting membrane 显示文摘 | Gandorfer A messmer EM Ulbig MW | 2000 | Retia2000，20，2： | 1 |
| 7 | Epiretinal pathology of diffuse diabetic macular edema associated with vitreomacular traction显示文摘 | Arnd Gandorfer Matthias Rohleder Sabine Grosselfinger Christos Haritoglou Michael Ulbig Anselm Kampik | 2005 | American Journal of Ophthalmology2005，，4： | 1 |
| 8 | Laser treatment in diabetic retinopathy 显示文摘 | Neubauer AS Ulbig MW | 2007 | Ophthalmologica2007，221，2： | 1 |
| 9 | 糖尿病视网膜病变中微动脉瘤荧光素渗出与视网膜增厚的关系(英文)显示文摘目的:观察糖尿病视网膜病变患者血管荧光素造影微动脉瘤处渗出与视网膜增厚的关系。方法:选取糖尿病视网膜病变患者24例38眼,首次及末次血管荧光素造影检查确定是否存在微动脉瘤荧光素渗出。根据毛细血管闭塞区的位置选取微动脉瘤荧光素渗出与未渗出各1眼配对进行对比。在微动脉瘤和直径为1mm区域使用光学相干断层成像术(OCT)测量视网膜厚度。结果:微动脉瘤荧光素渗出眼视网膜厚度明显高于未渗出眼(356±69μmvs318±56μm,P<0.001),渗出眼平均增长厚度高于未渗出眼(95%的可信区间为25~51μm,P<0.001).在直径为1mm区域,渗出眼视网膜厚度和平均增长厚度均明显高于未渗出眼(351±67μmvs319±59μm;最小值311±62μmvs284±60μm;最大值389±78μmvs352±66μm)。结论:血管荧光素造影显示微动脉瘤荧光素渗出可以增加视网膜厚度,并运用高分辨率OCT测量。因此,对糖尿病视网膜病变患者早期诊断微动脉瘤荧光素是否渗出可以抑制视网膜增厚。 | Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer | 2011 | 国际眼科杂志2011，11，7： | 1 |
| 10 | Diabetic retinopathy: Early diagnosis and effective treatment 显示文摘 | Kollias AN Ulbig MW | 2010 | Dtsch Arztebl Int2010，7，5： | 1 |
| 11 | Diabetic retinopathy:early diagnosis and effective treatment显示文摘 | Kollias AN Ulbig MW | | 0，，： | 1 |
| 12 | Resolution of diabetic macular edema after surgical removal of the posterior hyaloid and the inner limiting membrane 显示文摘 | Gandorfer A Messmer EM Ulbig MW | 2000 | Retina2000，20，： | 1 |
| 13 | Resolution of diabet- ic macular edema after surgical removal of the posterior hya- loids and the inner limiting membrane显示文摘 | Gandorfer A messmer EM Ulbig MW | 2000 | Retia2000，20，2： | 1 |
| 14 | Comparison of intravitreal bevacizumab versus triamcinolone for the treatment of diffuse diabetic macular edema显示文摘 | Rashid AL Saeidi K Kook D Wolf A Ulbig MW Neubauer AS | | 0，，： | 1 |
| 15 | In vitro safety of intravitreal moxifloxacin for endophthalmitis treatment显示文摘 | Kernt M Neubauer AS Ulbig MW | 2008 | J Cataract Refract Surg2008，34，3： | 1 |
| 16 | Transpupillary thermotherapy (TTT) in circumscribed choroidal hemangioma显示文摘 | Anne V. Fuchs Arthur J. Mueller Martin Grueterich Michael W. Ulbig | 2002 | Graefe’s Archive for Clinical and Experimental Ophthalmology2002，，1： | 1 |
| 17 | Long-term results after drainage of premacular subhyaloid hemorrhage into the vitreous with a pulsed Nd:YAG laser显示文摘 | Ulbig MW Mangouritsas G Rothbacher HH | | 0，，11： | 1 |
| 18 | Effect of calcium dobesilate on occurrence of diabetic macular oedema (CALDIRET study): randomised, double-blind, placebo-controlled, multicentre trial显示文摘 | Christos Haritoglou Joachim Gerss Cristina Sauerland Anselm Kampik Michael W Ulbig | 2009 | The Lancet2009，，9672： | 1 |
| 19 | Diabetic retinopathy:early diagnosis and effective treatment显示文摘 | Kollias AN Ulbig MW | 2010 | Dtsch Arztebl Int2010，107，5： | 1 |
| 20 | Reso- lution of diabetic macular edema after surgical removal of the posterior hyaloid and the inner limiting membrane 显示文摘 | Gandorfer A Messmer E M Ulbig M W | 2000 | Retina2000，20，： | 1 |
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