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| 1 | The parallel 3D magnetotelluric forward modeling algorithm显示文摘3D 磁电机的工作量碲的向前当模特儿的算法那么大传统的连续算法花费一极其大计算时间。然而,向前为算法建模的 3D 能在频率域处理数据,它对平行计算很合适。与 MPI 并且基于 3D 磁电机的流动的分析的优点碲的连续前面的算法,我们建议平行计算的想法并且使用它。三个理论模型被测试,实行效率处于不同状况被比较。结果显示向前为计算建模的平行 3D 是正确的,效率极大地被改进。这个方法对大尺寸合适地球物理的计算。 | Tan Handong Tong Tuo Lin Changhong | 2006 | Applied Geophysics2006，3，4： | 27 |
| 2 | High risk populations and HIV-1 infection in China显示文摘China is currently experiencing one of the most rapidly expanding HIV epidemics in the world. Although the overall prevalence rate is still low, with a population of 1.3 billion, high-risk factors which have contributed to the HIV/AIDS epidemics worldwide continue to prevail in China, including a high rate of injecting drug use and needle sharing, commercial sex with low rates of condom use, and concurrent sex with both commercial sex workers and noncom- mercial casual or steady sex partners. In addition, there are increasing “double risk” populations overlapping drug users and sex workers, as well as increasing rates of STDs and HIV among high-risk populations. Sexual transmission, therefore, may serve as a bridge connecting high-risk populations with general populations. There is an urgent need to prevent the spread of HIV from these high-risk populations into the general population of China. | Tuo Fu ZHU Chun Hui WANG Peng LIN Na HE | 2005 | Cell Research2005，15，11： | 10 |
| 3 | Features of colorectal cancer in China stratified by anatomic sites:A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018显示文摘Objective:The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer.However,for Chinese patients,there is limited information on the proportion of cases at each site and the related features.In this study,we explored the location,distribution and other features of colorectal cancers at each anatomic site in Chinese patients.Methods:We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018;the reports covered a total of 2,097,347 hospitalizations.Incident cases were chosen as the study population,and their epidemiological features were further analyzed.Results:A total of 20,739 colorectal cancer patients were identified.Rectum was the most common location(48.3%)of the cancer,whereas the proportions of patients with distal and proximal colon cancer were 24.5%and18.6%,respectively.Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites(each P<0.001).The highest proportion of emergency admissions,the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer(each P<0.001).The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy,cholecystolithiasis and/or gallbladder polyps and appendectomy(P=0.009,P<0.001 and P<0.001,respectively).The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension(P<0.001,respectively).Conclusions:The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer.Different epidemiological features were also found based on anatomic sites.Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment. | Ruize Qu Yanpeng Ma Liyuan Tao Xiaoyuan Bao Xin Zhou Bingyan Wang Fei Li Siyi Lu Lin Tuo Siyan Zhan Zhipeng Zhang Wei Fu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 10 |
| 4 | Three-dimensional conjugate gradient inversion of magnetotelluric full information data显示文摘基于阻抗张肌数据, tipper 数据,和conjugate 坡度算法的分析,我们发展一三维( 3D )为转换结合坡度算法完整的信息数据决定了从的 magnetotelluric 五电并且磁场部件并且讨论方法为 3D 倒置结果的量的解释使用完整的信息数据。从合成数据的 3D 倒置的结果显示从转换的结果更好联合张肌和 tipper 数据是的阻抗比的完整的信息数据源于转换仅仅阻抗张肌数据(或 tipper 数据) 在改进分辨率和可靠性。合成例子也表明这个 3D 倒置算法的有效性和稳定性。 | Lin Chang-Hong Tan Han-Dong Tong Tuo | 2011 | Applied Geophysics2011，8，1： | 8 |
| 5 | A novel scalable synthesis process of PPTA by coupling n-pentane evaporation for polymerization heat removal显示文摘In this study,we compared the effect of n-pentane and ice-water bath on removing the thermal effect in the poly(p-phenylene terephthalamide)(PPTA) polymerization process.The results indicate that the n-pentane can help to transfer the reaction heat faster and better.Adding suitable amount of n-pentanes into the PPTA preparation process not only improve the heat transfer,but also reduce the motor power in the polymerization process.Moreover,the introduction of n-pentane properly does not result in decrease of the inherent viscosity(η_(inh)) of polymer.Instead,it leads to increased viscosity of polymer during the PPTA preparation process.The results indicate that n-pentane can effectively transfer the reaction heat and avoid overheating during the polymerization of PPTA. | Tao Zhang Guo Hua Luo Fei Wei Yan Yan Lu Wei Zhong Qian Xin Lin Tuo | 2011 | Chinese Chemical Letters2011，22，11： | 8 |
| 6 | Tree of life for the genera of Chinese vascular plants显示文摘我们重建了使用的中国脉管的植物(Tracheophyta ) 的一棵种系发生的树叶绿体基因 atpB, matK, ndhF,和 rbcL 和 mitochondrial matR 定序。我们生产了包括 6098 种类并且包括 13 个 695 DNA 序列, 1803 最新被产生的一个矩阵。我们的分类采样跨越了代表中国脉管的植物的 323 个家庭的 3114 个类,盖住从中国知道的超过 93% 所有类。全面大发展史支持大多数关系在之中并且在最近的分子的种系发生的研究为 lycophytes,蕨纲植物(monilophytes ) ,裸子植物,和被子植物认出的家庭以内。为被子植物,在被子植物发展史组 IV 的大多数家庭作为 monophyletic 被养活,除了 paraphyletic Dipterocarpaceae 和 Santalaceae。一些大类的几个大家庭并且 monophyly 的 infrafamilial 关系被我们的稠密的分类采样很好支持。我们的结果证明 Eberhardtia 的二种是到 Sapotaceae 的所有另外的 taxa 形成的 clade 的姐妹,除了 Sarcosperma。我们经由 SoTree (http://gffzz52bf878016c04d01h0k096fowokcv6wf0.ffgz.tsg.suse.edu.cn/flora/index.shtml ) 做了我们为子树的创造公开地可得到的中国脉管的植物的发展史,为生态学家的一个自动化发展史集会工具。 | Zhi-Duan Chen Tuo Yang Li Lin Li-Min Lu Hong-Lei Li Miao Sun Bing Liu Min Chen Yan-Ting Niu Jian-Fei Ye Zhi-Yong Cao Hong-Mei Liu Xiao-Ming Wang Wei Wang Jing-Bo Zhang Zhen Meng Wei Cao Jian-Hui Li Sheng-Dan Wu Hui-Ling Zhao Zhong-Jian Liu Zhi-Yuan Du Qing-Feng Wang Jing Guo Xin-Xin Tan Jun-Xia Su Lin-Jing Zhang Lei-Lei Yang Yi-Ying Liao Ming-He Li Guo-Qiang Zhang Shih-Wen Chung Jian Zhang Kun-Li Xiang Rui-qi Li Douglas E. Soltis Pamela S. Soltis Shi-Liang Zhou Jin-Hua Ran Xiao-quan Wang Xiao-Hua Jin You-Sheng Chen Tian-Gang Gao Jian-Hua Li Shou-Zhou Zhang An-Ming Lu China Phylogeny Consortium | 2016 | Journal of Systematics and Evolution2016，54，4： | 5 |
| 7 | Impact of 5-Fu/oxaliplatin on mouse dendritic cells and synergetic effect with a colon cancer vaccine显示文摘Objective: The aim of the present study was to investigate the effects of 5-fluorouracil(5-Fu) and oxaliplatin on the function and activation pathways of mouse dendritic cells(DCs), and to clarify whether 5-Fu/oxaliplatin combined with the CD1d-MC38/α-galactosylceramide(α-GC) tumor vaccine exhibits synergistic effects on the treatment of colon cancer in mice.Methods: The combination of the Toll like receptor(TLR) ligands and/or 5-Fu/oxaliplatin was added into myeloid-derived DCs in vitro culture. DC phenotypic changes were detected by flow cytometry, and the secretion of DC cytokines was detected by cytometric bead array(CBA). A MC38 mouse colon cancer model was constructed and the DCs were isolated from the spleen, tumor tissue and lymph nodes following intraperitoneal injection of 5-Fu/oxaliplatin. The cell phenotypes were detected by flow cytometry. The tumor infiltrating leukocytes,splenocytes and lymph node cells were co-cultured with the dead MC38 tumor cells, and the secretion levels of interferon-γ(IFN-γ) were detected. 5-Fu/oxaliplatin combined with our previously developed CD1d-MC38/α-GC tumor vaccine was used to inhibit the growth of MC38 colon cancer in mice, and the tumor growth rate and survival time were recorded.Results: 5-Fu/oxaliplatin exerted no significant effect on the expression of the stimulating phenotypes of DCs in vitro, while it could reduce the expression of programmed death ligand 1/2(PD-L1/L2) and promote interleukin-12(IL-12) secretion by DCs. Furthermore 5-Fu/oxaliplatin was beneficial to the differentiation of T-helper 1(Th1) cells. 5-Fu/oxaliplatin further enhanced the stimulating phenotypic expression of DCs in tumor bearing mice, decreased PD-L1/L2 expression, and specifically activated the lymphocytes. The CD1d-MC38/α-GC tumor vaccine combined with 5-Fu/oxaliplatin could exert a synergistic role that resulted in a significant delay of the tumor growth rate, and an increase in the survival time of tumor bearing mice.Conclusions: 5-Fu/oxaliplatin decreased the expression of the DC inhibitory phenotypes PD-L1/L2, promoted DC phenotypic maturation in tumor bearing mice, activated the lymphocytes of tumor bearing mice, and exerted synergistic effects with the CD1d-MC38/α-GC colon cancer tumor vaccine. | Xinqiang Hong Tiangeng Dong Tuo Yi Jianwei Hu Zhen Zhang Shengli Lin Weixin Niu | 2018 | Chinese Journal of Cancer Research2018，30，2： | 4 |
| 8 | Comparison of sequential feeding and continuous feeding on the blood glucose of critically ill patients:a non-inferiority randomized controlled trial显示文摘Background:Glucose control is an important aspect in managing critically ill patients.The goal of this study was to compare the effects of sequential feeding(SF)and continuous feeding(CF)on the blood glucose of critically ill patients.Methods:A non-inferiority randomized controlled trial was adopted in this study.A total of 62 patients who were fed enteral nutritional suspension through gastric tubes were enrolled.After achieving 80%of the nutrition target calories(25 kcal·kg^(-1)·day^(-1))through CF,the patients were then randomly assigned into SF and CF groups.In the SF group,the feeding/fasting time was reasonably determined according to the circadian rhythm of the human body as laid out in traditional Chinese medicine theory.The total daily dosage of the enteral nutritional suspension was equally distributed among three time periods of 7 to 9 o’clock,11 to 13 o’clock,and 17 to 19 o’clock.The enteral nutritional suspension in each time period was pumped at a uniform rate within 2 h by an enteral feeding pump.In the CF group,patients received CF at a constant velocity by an enteral feeding pump throughout the study.Blood glucose values at five points(6:00/11:00/15:00/21:00/1:00)were monitored and recorded for seven consecutive days after randomization.Enteral feeding intolerance was also recorded.Non-inferiority testing was adopted in this study,the chi-square test or Fisher test was used for qualitative data,and the Mann-Whitney U test was used for quantitative data to determine differences between groups.In particular,a repeated measure one-way analysis of variance was used to identify whether changes in glucose value variables across the time points were different between the two groups.Results:There were no significant demographic or physiological differences between the SF and CF groups(P>0.050).The average glucose level in SF was not higher than that in CF(8.8[7.3–10.3]vs.10.7[9.1–12.1]mmol/L,Z=-2.079,P for non-inferiority=0.019).Hyperglycemia incidence of each patient was more common in the CF group than that in the SF group(38.4[19.1–63.7]%vs.11.8[3.0–36.7]%,Z=-2.213,P=0.027).Hypoglycemia was not found in either group.Moreover,there was no significant difference during the 7 days in the incidence of feeding intolerance(P>0.050).Conclusions:In this non-inferiority study,the average blood glucose in SF was not inferior to that in CF.The feeding intolerance in SF was similar to that in CF.SF may be as safe as CF for critically ill patients. | Chang-Jie Ren Bo Yao Miao Tuo Hui Lin Xiang-Yu Wan Xu-Feng Pang | 2021 | Chinese Medical Journal2021，，14： | 3 |
| 9 | Novel TRPM1 mutations in two Chinese families with early-onset high myopia, with or without complete congenital stationary night blindness显示文摘AIM:To investigate the relationship between high myopia [with or without complete congenital stationary night blindness(CSNB1)] and TRPM1 and NYX.METHODS: Two unrelated families with early-onset high myopia(eo HM) and 96 normal controls were recruited.Sanger sequencing or clone sequencing were used for mutation screening.Further analyses of the available family members and the 96 normal controls were subsequently conducted to obtain additional evidence of the pathogenicity of these variants.The initial diagnosis of the probands was eo HM.We performed a further comprehensive examination of the available family members after mutations were detected in TRPM1 or NYX. RESULTS: Two novel compound heterozygous mutations in TRPM1 were detected in the recruited families.The proband in family A with eo HM carried a c.2594 C >T missense mutation in exon 19 and a c.669 +3_669 +6del AAGT splicing mutation,which was co-segregated with CSNB1 in this family.A patient in family B with a compound heterozygous missense mutation(c.3262 G>A and c.3250 T>C) was detected.No mutations were found in NYX.These two identified compound heterozygous mutations were not found in the 96 normal controls.After further examination of the family members,the patients in family A could be diagnosed as eo HM with CSNB1.However due to the limited clinic data,the patient in family B cloud not clearly diagnosed as CSNB1.CONCLUSION: This study has expanded the mutation spectrum of TRPM1 for CSNB1 and additional studiesare needed to elucidate the association between isolated high myopia and TRPM1 and NYX. | Lin Zhou Tuo Li Yi-Qiao Xing Yin Li Qing-Song Wu Mao-Ju Zhang | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 3 |
| 10 | Dispositional characteristics of Ordovician Wufeng Formation and Silurian Longmaxi Formation in Sichuan Basin and its adjacent areas显示文摘According to data of gas wells and typical sections of Wufeng Formation and Longmaxi Formation in Sichuan Basin,shale of various graptolite zones were analyzed to determine depositional environment,lithology and thickness characteristics of the graptolite shale interval of WF2-WF3 in the lower part of Wufeng Formation,the graptolite shale interval of WF4 in Guanyinqiao Member of Wufeng Formation and the graptolite shale interval of LM1-LM4 in the bottom of Longmaxi Formation,and characteristics of shale horizontal distribution were also investigated.During the depositional period of the graptolite shale interval of WF2-WF3,the study area was less affected by the Guangxi movement,the depositional environment was the deep water of open sea,where black shale was mainly deposited;the sedimentation center was developed in northeast Guizhou-northeast Sichuan and south Sichuan,the maximum thickness was from 4 to 6 m in the sedimentation center.During the depositional period of the graptolite shale interval of WF4,the depositional environment in the study area changed greatly due to global sea level fall and enhanced Guangxi movement;the central Sichuan paleouplift,the central Guizhou paleouplift and the Jiangnan-Xuefeng palaeouplift were further expanded,and the area of the sedimentary basin decreased;the depositional environment was mainly carbonate bioclastic shoal of shallow sea,and partially deep sea which only was distributed in the Shizhu-Fuling-Wuxi area in east and northeast Sichuan and the Gongxian-Yongchuan area in south Sichuan;sediments of shallow water were dominated by limestone and argillaceous limestone with abundant Hirnantia,sediments of deep water were dominated by calcareous mudstone and shale with Hirnantia.During the depositional period of the graptolite shale interval of LM1-LM4,due to rise of global sea level and Guangxi movement,the sedimentary area was larger than that in the depositional period of Guanyinqiao Member,and the sedimentary environment mainly was stagnant deepwater;thickness of black shale in the graptolite shale interval of LM1-LM4 was large,and the maximum thickness was over 20 m.Furthermore,control of the central Sichuan paleouplift,the central Guizhou paleouplift and the Jiangnan-Xuefeng paleouplift on black shale was discussed,and control of the Zhiliujing underwater highland/uplift,Huayingshan highland and Dingshan highland as well as western Hubei-Hunan underwater highland/uplift on shale deposition and preservation was also investigated. | Haikuan Nie Zhijun Jin Xin Ma Zhongbao Liu Tuo Lin Zhenheng Yang | 2017 | Petroleum Research2017，2，3： | 3 |
| 11 | Long-term variations of X-ray pulse profiles for the Crab pulsar:data analysis and modeling显示文摘The pulse profiles of the Crab pulsar(as well as some other pulsars)vary with time.They can lead to a major source of intrinsic timing noise,which lacks a detailed physical model.The phase separation?between the first left peak(P1)and the second right peak(P2)is a key parameter that shows the variations of pulse profiles for the Crab pulsar.It was found that the evolution of?has a tendency with increasing rates of 0.82?±0.25?,0.80?±0.54?,and 0.77?±0.28?per century for the 2-6,6-15,and15-60 ke V bands,respectively.Furthermore,the flux ratios(P2/P1)of X-ray pulse profiles in the three bands were calculated,and the derived flux ratios were consistent with the radio and X-ray measurements of the Insight-HXMT.In addition to discovering the physical origin of the pulse changes,the high-SNR X-ray pulse profiles were simulated in the annular gap model,and two model parameters(e.g.,the maximum emission heights of the two peaks)were observed to slightly affect the variations of peak separation.We fitted the long-term variations of emission heights of the two peaks and discovered that the emission heights showed increasing tendencies with time.Variations of these emission heights induced a characteristic period derivative,and a complete formula for both the magnetic dipole radiation and wind-particle-induced variations of the moment of inertia was used for the pulsar’s spin-down to obtain the variation rate˙αof the magnetic inclination angle,which was-1.60?per century.Intrinsic timing noise is observed to be mainly induced by the variations of pulse profiles,which might correlate with a characteristic spin period derivative arising from the fluctuations of the emission regions.This work will lay a foundation for understanding the origin of intrinsic timing noise and making high-precision timing models in the future. | LunHua Shang YuanJie Du XiangQun Cui ShiJun Dang JiGuang Lu JunTao Bai QiJun Zhi YouLi Tuo LinLi Yan LiangWei Huang XinYuan Zhang XiaoMin Bei QingQing Lin GuoJun Qiao Hua Shen RiHong Zhu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 2 |
| 12 | Heterostructured ZnFe_2O_4/Fe_2TiO_5/TiO_2 Composite Nanotube Arrays with an Improved Photocatalysis Degradation Efficiency Under Simulated Sunlight Irradiation显示文摘To improve the visible light absorption and photocatalytic activity of titanium dioxide nanotube arrays(TONTAs), ZnFe_2O_4(ZFO) nanocrystals were perfused into pristine TONTA pipelines using a novel bias voltageassisted perfusion method. ZFO nanocrystals were well anchored on the inner walls of the pristine TONTAs when the ZFO suspensions(0.025 mg m L^(-1)) were kept under a60 V bias voltage for 1 h. After annealing at 750 °C for2 h, the heterostructured ZFO/Fe_2 TiO_5(FTO)/TiO_2 composite nanotube arrays were successfully obtained. Furthermore, Fe^(3+)was reduced to Fe^(2+)when solid solution reactions occurred at the interface of ZFO and the pristine TONTAs. Introducing ZFO significantly enhanced thevisible light absorption of the ZFO/FTO/TONTAs relative to that of the annealed TONTAs. The coexistence of type I and staggered type II band alignment in the ZFO/FTO/TONTAs facilitated the separation of photogenerated electrons and holes, thereby improving the efficiency of the ZFO/FTO/TONTAs for photocatalytic degradation of methylene blue when irradiated with simulated sunlight. | Kun Xiong Kunzhou Wang Lin Chen Xinqing Wang Qingbo Fan Jérémie Courtois Yuliang Liu Xianguo Tuo Minhao Yan | 2018 | Nano-Micro Letters2018，10，1： | 2 |
| 13 | In-situ doping-induced lattice strain of NiCoP/S nanocrystals for robust wide pH hydrogen evolution electrocatalysis and supercapacitor显示文摘Developing high-efficiency multifunctional nanomaterials is promising for wide p H hydrogen evolution reaction(HER) and energy storage but still challenging. Herein, a novel in-situ doping-induced lattice strain strategy of NiCoP/S nanocrystals(NCs) was proposed through using seed crystal conversion approach with NiCo_(2)S_(4) spinel as precursor. The small amount of S atoms in NiCoP/S NCs perturbed the local electronic structure, leading to the atomic position shift of the nearest neighbor in the protocell and the nanoscale lattice strain, which optimized the H* adsorption free energy and activated H_(2)O molecules, resulting the dramatically elevated HER performance within a wide p H range. Especially, the NiCoP/S NCs displayed better HER electrocatalytic activity than comical 20% Pt/C at high current density in 1 M KOH and natural seawater: it only needed 266 m V vs. reversible hydrogen electrode(RHE) and660 m V vs. RHE to arrive the current density of 350 m A cm^(-2) in 1 M KOH and natural seawater, indicating the application prospect for industrial high current. Besides, NiCoP/S NCs also displayed excellent supercapacitor performance: it showed high specific capacity of 2229.9 F g^(-1) at 1 A g^(-1) and energy density of87.49 Wh kg^(-1), when assembled into an all-solid-state flexible device, exceeding performance of most transition metal phosphides. This work provides new insights into the regulation in electronic structure and lattice strain for electrocatalytic and energy storage applications. | Yan Lin Xiaomeng Chen Yongxiao Tuo Yuan Pan Jun Zhang | 2022 | Journal of Energy Chemistry2022，31，7： | 2 |
| 14 | Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detected by RNA-seq显示文摘Phosphoenolpyruvate carboxykinase 1(PCK1),a step limiting enzyme of gluconeogenesis,is downregulated in hepatocellular carcinoma(HCC).Overexpression of PCK1 has been shown to suppress hepatoma cell growth,but the underlying mechanism remains unclear.We used recombinant adenovirus overexpressing PCK1 or GFP in Huh7 cells,and the differentially expressed genes(DEGs)were identified by RNA-Seq.180 were upregulated by PCK1 overexpression,whereas 316 were downregulated.Pathway analysis illustrated that PCK1 was closely correlated with Wnt signaling pathway and TGF-beta signaling pathway.Hence,Wnt signaling pathway and its downstream component,FZD2,FZD6,FZD7 and b-catenin were confirmed by qRT-PCR and Western blot.In vivo we also observed that PCK1 had restrained tumor growth as a result of decreasing expression of b-catenin.Whole-transcriptomic profile analysis discovered that overexpression of PCK1 downregulates several oncogenic signaling pathways in HCC,providing potential therapeutic targets for improving HCC therapy. | Jin Xiang Yuhong Zhang Lin Tuo Rui Liu Dongmei Gou Li Liang Chang Chen Jie Xia Ni Tang Kai Wang | 2020 | Genes & Diseases2020，7，1： | 2 |
| 15 | Clinical Predictors for Diagnosing Pandemic (H1N1) 2009 and Seasonal Influenza (H3N2) in Fever Clinics in Beijing,China显示文摘Objective Symptomatic predictors of influenza could assess risks and improve decisions about isolation and outpatient treatment.To develop such predictors,we undertook a prospective analysis of pandemic (H1N1) 2009 and seasonal influenza (H3N2) in patients attending fever clinics.Methods From 1 May 2009 to 1 January 2010,all adult patients admitted to fever clinics for suspected influenza,confirmed by real time RT-PCR,were enrolled.Predictors of influenza virus infection were selected with logistic regression models.Measures of sensitivity,specificity,positive and negative likelihood ratios (LRs) were calculated to identify the best predictors.Results The clinical features and routine blood test results of influenza (H1N1) 2009 and seasonal influenza were similar.The positive and negative LRs of current US CDC influenza-like illness (ILI) criteria were modest in predicting influenza infection.Our modified clinic predictors improved the ability of the positive and negative LRs to recognize pandemic (H1N1) 2009 and seasonal influenza.The revised criteria are:fever ≥38℃ accompanied by at least one of the following—cough,arthralgia or relative lymphopenia.Conclusion Patients with symptoms and signs that meet the new criteria are likely to have influenza and timely antiviral therapy may be appropriate.In addition,physicians should ascertain if influenza is circulating within the community or if there is a contact history of influenza and combine this information with the newly developed criteria to clinically diagnose influenza. | DAI Xiao Qiu LIU Min ZHANG Tuo Hong YANG Xue Song LI Song Lin LI Xiao Guang LI Yu Ling KADEERBAI Hai San WU Huang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 2 |
| 16 | 过表达CXCR4的骨髓间充质干细胞通过增强的肠道归巢能力抑制小鼠肠炎相关肿瘤的形成显示文摘背景:骨髓来源间充质干细胞(MSC)用于炎症性肠病(IBD)及IBD相关肠癌的治疗潜力已受到越来越多的关注。然而,MSC究竟是抵制还是促进肿瘤形成仍然存在争议。基质细胞衍生因子1(SDF-1)/C-X-C趋化因子受体4(CXCR4)在MSC归巢过程具有非常关键的作用。本研究旨在评估过表达CXCR4的MSC在IBD瘤变过程中的作用。方法:应用携带CXCR4或绿色荧光蛋白(GFP)的慢病毒载体转染MSC。通过细胞趋化实验和侵袭实验检测CXCR4表达情况。采用偶氮甲烷和葡聚糖硫酸钠(DSS)制作小鼠结肠炎成瘤模型。将实验小鼠分为3组,分别注射磷酸盐缓冲液(PBS)、MSC-GFP或MSC-CXCR4。结果:与MSC-GFP组小鼠相比,MSC-CXCR4小鼠体重下降程度减少,结肠相对更长,肿瘤数量更少,肿瘤负荷减轻;此外,结肠组织中促炎细胞因子表达和STAT3磷酸化水平均下调。结论:过表达CXCR4的MSC表现出抑瘤功能,其机制可能是CXCR4促进MSC向炎性肠组织的归巢。 | Xiao-Bin Zheng Xiao-Wen He Long-Juan Zhang Hua-Bo Qin Xu-Tao Lin Xuan-Hui Liu Chi Zhou Hua-Shan Liu Tuo Hu Hai-Chun Cheng Xiao-Sheng He Xian-Rui Wu Yu-Feng Chen Jia Ke Xiao-Jian Wu Ping Lan | 2019 | Gastroenterology Report2019，7，2： | 2 |
| 17 | Shale gas accumulation conditions and gas-bearing characteristics of the Lower Cambrian Niutitang Formation in Well Changye-1 in northwestern Hunan Province显示文摘To evaluate the accumulation conditions and gas-bearing properties of shale gas in the Lower Cambrian Niutitang Formation,northwestern Hunan Province,the first shale gas parameter well(Well Changye-1)that takes the Niutitang Formation as the target horizon in the Hunan Province was selected preferably and drilled,cumulatively revealing the thickest dark shale horizon of the Niutitang Formation among the single-well drillings in China,with a true vertical thickness of 674.5m.Through analyzing the core samples in terms of organic geochemistry,rock mineralogy and reservoir properties,the black shale horizons in the Niutitang Formation of Well Changye-1 have high organic carbon content(average 3.9%),moderate maturity(equivalent Ro average 2.6%),high brittle mineral content(quartz content average 50.1%),low clay mineral content(average 32.4%),low porosity(1.7%)and low permeability(1.32×10^(-3)mD),and well-developed meso to micro-pores and fractures,indicating good conditions for shale gas accumulation.Field desorption and laboratory isothermal adsorption measurements on core samples show that Well Changye-1 has good gas-bearing properties,and gas content generally increases with depth.The black shale horizons at the depth of 1100-1250m have an average organic carbon content up to 10.1%,total gas content of 0.5-2.1m^(3)/t and 3.7-6.4m^(3)/t,and this is the most favorable depth for shale gas development,indicating that the Niutitang Formation has good a prospect for shale gas exploration.Due to huge sedimentary thickness,the black shale in the middle-lower part of the Niutitang Formation should be given priority for exploration. | Tuo Lin Shujing Bao Jinchuan Zhang Zhi Zhou Kun Yuan Bo Li Shengyu Yang | 2016 | Petroleum Research2016，1，2： | 2 |
| 18 | Geochemical characteristics and sedimentary environment of the Middle Devonian organic-rich shales in the Northwest of Guizhong Depression, Southwest China显示文摘In order to figure out the redox conditions and paleo-sedimentary environment of the Middle Devonian shales in the northwest of Guizhong Depression,the trace element analysis was conducted on the Middle Devonian cores(320.35–938.50 m)of the typical shale gas investigation well(GY-1)at a 1.50 m sampling interval through X-ray fluorescence spectroscopy(XRF)and inductively coupled plasma mass spectrometry(ICP-MS).According to the test result,the average values of V/(V+Ni),V/Cr and Ni/Co in Nabiao formation(Fm.)are larger than 0.67,4.65 and 7.71 respectively,and Nabiao Fm.is rich in biological assemblages such as tabasheer,ammonite,etc.These evidences indicate the rising sea level rose relatively in the sedimentation period of Nabiao Fm.and a deepwater shelf environment,which was favorable for the preservation of organic matters.The V/(V+Ni),V/Cr and Ni/Co in Luofu Fm.and Tangting Fm.are 0.38–0.65,0.73–4.10 and 3.70–6.72 respectively,indicating that the sea level dropped relatively in their sedimentation period,during which the water bodies became shallow,and the sedimentary environment was a weak oxidizing shallow water shelf environment.In addition,the variation of TOC has a high correlation with the enrichment degree of Ba element,indicating the favorable conditions for the enrichment and preservation of organic matters under an oxygen-deficient environment.Moreover,according to the identification of trace element indexes,the northwest of Guizhong Depression experienced the sedimentary cycle of relative rise to relative fall of sea level from bottom to top in the Middle Devonian sedimentation period.The relative sea level rose to the highest in the sedimentation period of Nabiao Fm.,in which the organic-rich shales with stable thickness and high organic content were deposited.Hence,the Nabiao Fm.could be regarded as the favorable exploration target interval in this area. | Kun Yuan Wen-hui Huang Xin-xin Fang Shi-zhen Li Ting Wang Tuo Lin Guo-heng Liu | 2020 | China Geology2020，3，4： | 2 |
| 19 | Highly stable lithium anode enabled by self-assembled monolayer of dihexadecanoalkyl phosphate显示文摘Li has been considered as the ultimate anode material for high energy density secondary Li batteries.However,its practical application has been limited due to its low Coulombic efficiency(CE)and the formation of lithium dendrites.Recently,we have developed a microspherical Li-carbon nanotube(Li-CNT)composite material passivated with octadecylphosphonic acid(OPA)self-assembled monolayer(SAM)exhibiting suppressed lithium dendrite formation and improved environmental/electrochemical stability.In this work,we demonstrated the significantly enhanced passivation effects of a SAM using dihexadecanoalkyl phosphate(DHP),a molecule that is comprised of double hydrophobic alkyl chains and forms a denser SAM on surfaces with large curvature.As a result,the DHP SAM delivers superior environmental and electrochemical stability to the OPA passivated Li-CNT material.In specific,the DHP passivated Li-CNT composite(DHP-Li-CNT)delivers a high CE of 99.25%under a 33.3%depth of discharge(DOD)at 1 C,when it is paired with a LiFePO4 cathode.The evolution of the SAM during cycling and the effects of DOD and current density on the CE of the DHP-Li-CNT anode have also been investigated.The improved SAM passivation constitutes an important step in achieving the goal of practically applicable Li anodes. | Lei Zheng Feng Guo Tuo Kang Jin Yang Ya Liu Wei Gu Yanfei Zhao Hongzhen Lin Yanbin Shen Wei Lu Liwei Chen | 2020 | Nano Research2020，13，5： | 1 |
| 20 | Synthesis and UVabsorption properties of 5-sulfosalicylate-intercalated Zn-Allayered double hydroxides显示文摘 | Zhang L Y Lin Y J Tuo Z J | 2007 | Journal of Solid StateChemistry2007，180，4： | 1 |
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