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| 1 | Effects of dietary alfalfa flavonoids extraction on growth performance,organ development and blood biochemical indexes of Yangzhou geese aged from 28 to 70 days显示文摘This experiment was conducted to study the effects of dietary alfalfa flavonoids extraction supplemental level on growth performance, organ development and blood biochemical indexes of Yangzhou geese at the age of 28 to 70 days. Two hundred and forty 21-day-old healthy male geese with similar body weight were randomly distributed into 4 groups with 6 replicates per group and 10 geese per replicate. Geese in the control group were fed a basal diet and the others in the experimental groups(groups 1,2, and 3) were fed experimental diets supplemented with 150, 300 and 450 mg/kg alfalfa flavonoids extraction(the concentration of it was 81%), respectively. The experiment had 7 days for pre-test and 42 days for formal test.The results showed that the final body weight and average daily intake of group 2 were significantly higher than those of other groups(P < 0.05). The average daily gain of group 2 was significantly higher than that in the control group and group 1(P < 0.05). There was no significant difference in feed-to-gain ratio between each group(P > 0.05). Pre-slaughter live weight, carcass weight, slaughter rate, semieviscerated weight, semi-eviscerated rate, eviscerated weight, eviscerated rate, leg muscle weight and leg muscle rate had no significant difference between each group(P > 0.05). The breast muscle weight and ratio of each test group were significantly higher than those in the control group(P < 0.05) and the group2 was the best. The abdominal fat weight and ratio in the group 1 were significantly higher than those in the control group and group 3(P < 0.05) and the tibia weight in the group 2 was significantly higher than that in the control group and group 1(P < 0.05); There were no significant differences in heart weight,liver weight and the gland stomach weight among all groups(P > 0.05). Spleen weight in test groups was significantly higher than that in the control group(P < 0.05). The bursa weight and muscular stomach weight in the group 2 were significantly higher than those in the control group and group 1(P < 0.05). In serum, total cholesterol, triglycerides, low-density lipoprotein and urea nitrogen in the group 2 were significantly lower comparing with those in the control group(P < 0.05). High-density lipoprotein in the group 2 was significantly higher than that in other groups(P < 0.05). There were no significant differences in total serum protein, albumin, globulin and albumin/globulin among all groups(P > 0.05). Alanine aminotransferase and aspartate transaminase(AST) in groups 2 and 3 were higher than those in the group1 and control group but not obvious(P > 0.05) and alkaline phosphatase(ALP) in groups 1 and 2 was higher than that in the control group and group 3(P > 0.05). It is concluded that alfalfa flavonoids extraction added in dietary feed improve the growth performance, organ development and blood biochemical indexes of Yangzhou geese. It is concluded that 300 mg/kg supplemental level of the dietary alfalfa flavonoids extraction is optimal in this experiment. | Yinyin Chen Xiaoxiao Gong Guodong Li Miao Lin Yongjiu Huo Shengli Li Guoqi Zhao | 2016 | Animal Nutrition2016，，4： | 14 |
| 2 | Impact of KRAS mutation and PTEN expression on cetuximab-treated colorectal cancer显示文摘AIM:To investigate the prognostic value of KRAS mutation,and phosphatase and tensin (PTEN) expression in Chinese metastatic colorectal cancer metastatic colorectal cancer (mCRC) patients treated with cetuximab.METHODS:Ninety Chinese mCRC patients treated with cetuximab were evaluated for KRAS mutation and PTEN protein expression by DNA sequencing of codons 12 and 13 and immunohistochemistry,respectively.We then selected 61 patients treated with cetuximab,either in combination with chemotherapy,or alone as a second-line or third-line regimen to assess whether KRAS mutation or PTEN protein expression is associated with the response and the survival time of mCRC patients treated with cetuximab.RESULTS:KRAS mutation was found in 30 (33.3%) tumor samples from the 90 patients,and positive PTEN expression was detected in 58 (64.4%) of the 90 patients.Among the 61 patients who were treated with cetuximab as a second-line or third-line regimen,the resistance to cetuximab was found in 22 patients with KRAS mutation and in 39 patients without KRAS mutation,with a response rate of 4.5% and 46.1% respectively (P=0.001),a shorter median progression-free survival (PFS) time of 14 ± 1.3 wk and 32 ± 2.5 wk respectively (P < 0.001),a median overall survival (OS) time of 11 ± 1.2 mo and 19 ± 1.8 mo respectively (P < 0.001),as well as in 24 patients with negative PTEN expression and in 37 patients with positive PTEN expression respectively (P < 0.001),with a responsive rate of 4.2% and 48.6% respectively,a shorter median PFS survival time of 17 ± 2.0 wk and 28 ± 1.9 wk respectively (P=0.07),and a median OS time of 11 ± 1.3 mo and 18 ± 1.9 mo respectively (P=0.004).Combined KRAS mutation and PTEN expression analysis showed that the PFS and OS time of patients with two favorable prognostic factors were longer than those of patients with one favorable prognostic factor or no favorable prognostic factor (P < 0.001).CONCLUSION:KRAS mutation and PTEN protein expression are significantly correlated with the response rate and survival time of Chinese mCRC patients treated with cetuximab. | Fang-Hua Li,Zhuang-Hua Li,Hui-Yan Luo,Miao-Zhen Qiu,Yu-Hong Li,Rui-Hua Xu,State Key Laboratory of Oncology in Southern China,Department of Medical Oncology,Sun YatSen University Cancer Center,Guangzhou 510060,Guangdong Province,China Fang-Hua Li,Department of Medical Oncology,Shengli Oil Field Central Hospital,Dongying 257034,Shandong Province,China Lin Shen,Department of GI Oncology,Peking University School of Oncology,Beijing Cancer Hospital and Institute,Beijing 100142,China Hui-Zhong Zhang,State Key Laboratory of Oncology in Southern China,Department of Pathology,Sun Yat-Sen University Cancer Center,Guangzhou 510060,Guangdong Province,China | 2010 | World Journal of Gastroenterology2010，16，46： | 9 |
| 3 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 4 | Impact of 5-Fu/oxaliplatin on mouse dendritic cells and synergetic effect with a colon cancer vaccine显示文摘Objective: The aim of the present study was to investigate the effects of 5-fluorouracil(5-Fu) and oxaliplatin on the function and activation pathways of mouse dendritic cells(DCs), and to clarify whether 5-Fu/oxaliplatin combined with the CD1d-MC38/α-galactosylceramide(α-GC) tumor vaccine exhibits synergistic effects on the treatment of colon cancer in mice.Methods: The combination of the Toll like receptor(TLR) ligands and/or 5-Fu/oxaliplatin was added into myeloid-derived DCs in vitro culture. DC phenotypic changes were detected by flow cytometry, and the secretion of DC cytokines was detected by cytometric bead array(CBA). A MC38 mouse colon cancer model was constructed and the DCs were isolated from the spleen, tumor tissue and lymph nodes following intraperitoneal injection of 5-Fu/oxaliplatin. The cell phenotypes were detected by flow cytometry. The tumor infiltrating leukocytes,splenocytes and lymph node cells were co-cultured with the dead MC38 tumor cells, and the secretion levels of interferon-γ(IFN-γ) were detected. 5-Fu/oxaliplatin combined with our previously developed CD1d-MC38/α-GC tumor vaccine was used to inhibit the growth of MC38 colon cancer in mice, and the tumor growth rate and survival time were recorded.Results: 5-Fu/oxaliplatin exerted no significant effect on the expression of the stimulating phenotypes of DCs in vitro, while it could reduce the expression of programmed death ligand 1/2(PD-L1/L2) and promote interleukin-12(IL-12) secretion by DCs. Furthermore 5-Fu/oxaliplatin was beneficial to the differentiation of T-helper 1(Th1) cells. 5-Fu/oxaliplatin further enhanced the stimulating phenotypic expression of DCs in tumor bearing mice, decreased PD-L1/L2 expression, and specifically activated the lymphocytes. The CD1d-MC38/α-GC tumor vaccine combined with 5-Fu/oxaliplatin could exert a synergistic role that resulted in a significant delay of the tumor growth rate, and an increase in the survival time of tumor bearing mice.Conclusions: 5-Fu/oxaliplatin decreased the expression of the DC inhibitory phenotypes PD-L1/L2, promoted DC phenotypic maturation in tumor bearing mice, activated the lymphocytes of tumor bearing mice, and exerted synergistic effects with the CD1d-MC38/α-GC colon cancer tumor vaccine. | Xinqiang Hong Tiangeng Dong Tuo Yi Jianwei Hu Zhen Zhang Shengli Lin Weixin Niu | 2018 | Chinese Journal of Cancer Research2018，30，2： | 4 |
| 5 | Synthesis,photophysical properties and TD-DFT calculation of four two-photon absorbing triphenylamine derivatives显示文摘In this study,linear absorption,single-photon excited fluorescence,fluorescence quantum yields,fluorescence lifetime and two-photon excited fluorescence of a series of triphenylamine derivatives (L1,L2,L3 and L4) have been measured.L1 and L3 are D--A type dyes,while L2 and L4 are D--D--A type dyes (D=donor,A=acceptor).The investigated compounds consist of triphenylamine-bearing donor-substituted and/or systematically extended-conjugated length,which are designed to gain insight into the effect of the ethoxyl unit and-linkage length on the linear and nonlinear optical properties.The influence of solvent polarity on the photophysical properties was investigated.Employing time-dependent density functional theory (TD-DFT) calculations,the structure-property relationships are discussed. | KONG Lin YANG JiaXiang ZHOU HongPing LI ShengLi HAO FuYing ZHANG Qiong TU YuLong WU JieYing XUE ZhaoMing TIAN YuPeng | 2013 | Science China Chemistry2013，56，1： | 3 |
| 6 | Simultaneous quantification of hepatic MRI-PDFF and R2* in a rabbit model with nonalcoholic fatty liver disease显示文摘Quantification of hepatic fat and iron content is important for early detection and monitoring of nonalcoholic fatty liver disease(NAFLD) patients. This study evaluated quantification efficiency of hepatic proton density fat fraction(PDFF) by MRI using NAFLD rabbits. R2* was also measured to investigate whether it correlates with fat levels in NAFLD. NAFLD rabbit model was successfully established by high fat and cholesterol diet. Rabbits underwent MRI examination for fat and iron analyses,compared with liver histological findings. MR examinations were performed on a 3.0 T MR system using multi-echo 3 D gradient recalled echo(GRE) sequence. MRI-PDFF showed significant differences between different steatosis grades with medians of3.72%(normal), 5.43%(mild), 9.11%(moderate) and 11.17%(severe), whereas this was not observed in R2*. Close correlation between MRI-PDFF and histological steatosis was observed(r=0.78, P=0.000). Hepatic iron deposit was not found in any rabbits. There was no correlation between R2* and either liver MRI-PDFF or histological steatosis. MR measuring MRI-PDFF and R2* simultaneously provides promising quantification of steatosis and iron. Rabbit NAFLD model confirmed accuracy of MRI-PDFF for liver fat quantification. R2* measurement and relationship between fat and iron of NAFLD liver need further experimental investigation. | Xiaomin Wang Xiaojing Zhang Lin Ma Shengli Li | 2018 | Science China(Life Sciences)2018，61，9： | 2 |
| 7 | RECENT DEVELOPMENT OF ERROR CONTROL CODES FOR FUTURE COMMUNICATION AND STORAGE SYSTEMS显示文摘The outstanding performance of error control codes has attracted the interest of the information and communications theory community and industry partners for more than 20 years since Turbo codes were invented.In recent years,there are more and more scenarios in modern communication and digital storage systems,such as wireless communications,optical communications,fl ash memories,computer hard drives,sensor networks, | zesong fei jinhong yuan ming xiao baoming bai shengli zhang dengsheng lin | 2017 | China Communications2017，14，8： | 2 |
| 8 | Endoscopic sphincterotomy plus balloon dilation versus endoscopic sphincterotomy for choledocholithiasis: A meta‐analysis显示文摘 | Yangyang Liu Peizhu Su Yinghao Lin Siheng Lin Kun Xiao Pingyan Chen Shengli An Yang Bai Fachao Zhi | 2013 | J Gastroenterol Hepatol2013，，6： | 2 |
| 9 | HASN:A Hierarchical Attack Surface Network for System Security Analysis显示文摘Attack surfaces, as one of the security models, can help people to analyse the security of systems in cyberspace, such as risk assessment by utilizing various security metrics or providing a cost-effective network hardening solution. Numerous attack surface models have been proposed in the past decade,but they are not appropriate for describing complex systems with heterogeneous components. To address this limitation, we propose to use a two-layer Hierarchical Attack Surface Network(HASN) that models the data interactions and resource distribution of the system in a component-oriented view. First, we formally define the HASN by extending the entry point and exit point framework. Second, in order to assess data input risk and output risk on the HASN, we propose two behaviour models and two simulation-based risk metrics. Last, we conduct experiments for three network systems. Our experimental results show that the proposed approach is applicable and effective. | Kangyu Huang Lin Yang Renfang Fu Shengli Zhou Zheng Hong | 2019 | China Communications2019，16，5： | 1 |
| 10 | Endoscopic sphincterotomy plus balloon dilation versus endoscopic sphincterotomy for choledocholithiasis: A meta‐analysis显示文摘 | Yangyang Liu Peizhu Su Yinghao Lin Siheng Lin Kun Xiao Pingyan Chen Shengli An Yang Bai Fachao Zhi | 2013 | J Gastroenterol Hepatol2013，，6： | 1 |
| 11 | How mobile messaging apps users share information on WeChat: The role of demographic variables显示文摘Purpose: We conducted an empirical study to find out the role of demographic variables in affecting information sharing behaviors of college student users of We Chat. Design/methodology/approach: A questionnaire survey was carried out to investigate the relationship between demographic variables(gender, grade level, dating status, and singleparent family background) and information sharing behaviors of We Chat users. The participants were college students and a total of 255 valid questionnaires were collected. Data was analyzed using descriptive statistics and multiple regression analysis.Findings: Grade level and single-parent family background were found to be significantly correlated with information sharing behaviors whereas no effect of gender was found on information sharing behaviors. Dating status had no significant impact on user browsing behavior, but was related to users' publishing posts and posting replies.Implications: The study will help understand individual differences in information sharing among We Chat users.Limitations: First, the relatively small sample size is a limitation in exploring the effects of demographic variables on user information sharing behaviors. Second, this study only used questionnaire surveys to collect data and more research methods such as interviews should be adopted to improve the accuracy of the study results.Originality/value: This paper is one of the first studies to explore the relationship between demographic variables and user information sharing behaviors on We Chat. | Shengli DENG Yanqing LIN | 2015 | Chinese Journal of Library and Information Science2015，，4： | 1 |
| 12 | Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics显示文摘 | Yonghui Zhang Xiaojing Lin Fengwei Zhang Jia Wu Wenjie Tan Shengli Bi Jianfang Zhou Yuelong Shu Yue Wang | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 13 | Hepatitis C virus envelope glycoproteins complementation patterns and the role of the ecto- and transmembrane domains显示文摘 | Xiaojing Lin Yonghui Zhang Shengli Bi Jian Lu Honglan Zhao Wenjie Tan Dexin Li Yue Wang | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 14 | Elevated expression of DKK1 is associated with cytoplasmic/nuclear β-catenin accumulation and poor prognosis in hepatocellular carcinomas显示文摘 | Bin Yu Xinrong Yang Yang Xu Genfu Yao Huiqun Shu Biaoyang Lin Leroy Hood Hongyang Wang Shengli Yang Jianren Gu Jia Fan Wenxin Qin | 2008 | Journal of Hepatology2008，，5： | 1 |
| 15 | Cloning and Bioinformatics Analysis of PsSFBB Gene in Xinjiang Pear显示文摘[Objective] This study aimed to clone the PsSFBB gene from Xinjiang pear for bioinformatics analysis.[Method] PsSFBB gene was cloned from anthers of Qipan pear by using RT-PCR and RACE technologies for bioinformatics analysis.[Result] A SFBB6-α gene with a full-length of 1 231 bp was cloned and named PsSFBB6-α(Genbank accession number:EU909685).PsSFBB6-α gene encodes a protein of 378 amino acids,with an F-box motif composed of about 50 amino acids in the N-terminal.According to the bioinformatics analysis,the molecular formula of PsSFBB6-α protein is C2000H3034N517O558S23,with relative molecular mass of 43 987.5 and isoelectric point of 6.02,and the secondary structure is dominated by α-helices;theoretically,the half life period is 30 h and the instability parameter is 55.21,so PsSFBB6-α protein is an instable protein;in addition,it is predicted that PsSFBB6-α protein is a hydrophilic and non-secreted protein with lyases activity and specifically recognized substrates,which was consistent with the function of F-box protein.[Conclusion] This study laid the foundation for further research on SFBB proteins and the mechanism of self-incompatibility and provided theoretical basis for breeding of self-compatible cultivars of Xinjiang pear and scientific arrangement of pollination trees in production to increase the yield and quality. | Shengli XU Xiaoqing CHEN Minjuan LIN Jiangbo WANG Jianping BAO Danna LIANG Jingjing WANG Beibei TIAN | 2012 | Agricultural Biotechnology2012，1，1： | 1 |
| 16 | High phosphorylated cyclin-dependent kinase 2 expressionindicates poor prognosis of luminal androgen receptortriple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is a highly aggressive breast cancer subtype characterized by a lack of estrogen receptorα(ER)and progesterone receptor(PR)expression and the absence of HER2 overexpression or amplification. | Zining Jin Qingfu Zhang Chunyu Wang Shengli Wang Lin Lin Renlong Zou Ge Sun Kai Zeng Baosheng Zhou Yuxin Tong Bo Chen Yue Zhao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 1 |
| 17 | Estimation of the Postmortem Interval by Measuring Blood Oxidation‑reduction Potential Values显示文摘Accurate estimation of the postmortem interval(PMI)is an important task in forensic practice.In the last half-century,the use of postmortem biochemistry has become an important ancillary method in determining the time of death.The present study was carried out to determine the correlation between blood oxidation-reduction potential(ORP)values and PMIs,and to develop a three-dimensional surface equation to estimate the PMI under various temperature conditions.A total of 48 rabbits were placed into six groups and sacrificed by air embolism.Blood was obtained from the right ventricle of each rabbit,and specimens were stored at 10℃,15℃,20℃,25℃,30℃,and 35℃.At different PMIs(once every 4 h),the blood ORP values were measured using a PB-21 electrochemical analyzer.Statistical analysis and curve fitting of the data yielded cubic polynomial regression equations and a surface equation at different temperatures.Result:The results showed that there was a strong positive correlation between the blood ORP values at different temperatures and the PMI.This study provides another example of using a three-dimensional surface equation as a tool to estimate the PMI at various temperature conditions. | Zhuqing Jiang Meng You Xu Wang Di Lu Haidong Zhang Shengli Di Fengqin Zhang Zhaoming Guo Xiaofei E Lin Chang Jian Xiang Rufeng Bai Tiantong Yang | 2016 | Journal of Forensic Science and Medicine2016，2，1： | 0 |
| 18 | Facet-induced coordination competition for highly ordered CsPbBr_(3) nanoplatelets with strong polarized emission显示文摘Controllable anisotropic growth of perovskite nanocrystals(NCs)is challenging since it is difficult to separate the nucleation and growth processes.Here,a two-step nucleation strategy is proposed to control the binding interaction between surface ligands and NCs,resulting in facet-induced coordination competition.Oleic acid as surface activated ligand leads to the formation of defective lead bromine octahedron,and the binding interaction between 4-dodecylbenzenesulfonic acid and lead atoms promotes the formation of two kinds of binding interactions.Based on this strategy,the anisotropic growth of CsPbBr_(3) nanoplatelet(NPLs)with adjusted length from 11.4 to 24 nm,and the evolution of NPLs from stacked to tongue-shaped have been realized.Elemental line scan reveals the sulfur atoms mainly distribute at the edge of NPLs.Furthermore,binding energy calculation and experimental results illustrate the coordination competition of different binding interaction on specific facets induces the anisotropic growth of NPLs.Importantly,strong emission anisotropy of highly ordered NPLs with polarization ratio up to 0.58 is illustrated.This work not only deepens our understanding of the controllable synthesis of perovskite NCs,but also provides a reference for the regulation of light emitting diode and soler cells. | Dandan Yang Xiaoming Li Yuelei Li Bo Cai Lin Su Shengli Zhang Zhili Juan Cuifang Meng Dongling Geng Jiaxin Chen Feng Xu Haibo Zeng | 2022 | Nano Research2022，15，1： | 0 |
| 19 | Structural Characterization and Biological Activity of Oligopeptides from Isochrysis zhanjiangensis:Based on Quantum Mechanics,Molecular Docking and in Vitro Experiments显示文摘DAPTMGY(DTY)is an oligopeptide derived from marine microalgae with proven potential to combat oxidative stress in previous research.The composition,ordering,and active sites of amino acids play a key role in activity studies and are also the research trends in recent years.As an oligopeptide with a molecular weight of less than 1000 Da,DTY is of great significance to explore the active site and structure-activity relationship.This study used quantum mechanics to optimize DTY’s structure and predict the active site through molecular orbits,energy,and charge.In addition,an LPS-treated HUVEC cell was established as an oxidative-stress model.DTY could reduce mitochondrial oxidative stress and inhibit ROS production by enhancing the antioxidant enzymes SOD,GPX,and HO-1.Moreover,it was confirmed to inhibit inflammation and apoptosis through the NF-κB and MAPK signaling pathways.Lastly,the correlation of the oligopeptide DTY’s active site and antioxidative-stress activity was verified by molecular docking,showing that hydrogen bonding is the main force,which was also the main factor for antioxidant activity. | LIN Liyuan LI Huijuan HONG Pengzhi ZHOU Chunxia SUN Shengli QIAN Zhongji | 2023 | Journal of Ocean University of China2023，22，4： | 0 |
| 20 | Study on Effects of Ascorbyl Propyl Hyaluronate显示文摘The moisturizing,barrier protection,firming effects of Ascorbyl Propyl Hyaluronate(V_(C)-HA)are studied.The moisturizing effect was evaluated by detecting hygroscopicity and water-retention capacity.A model of 3D skin injury was established to evaluate the barrier protection effect by detecting the changes in the histomorphological structure of the model and the barrier related proteins.Expression level of type Ⅰ collagen in FB was detected to evaluate the firming effect(Filaggrin,FLG).The results show that V_(C)-HA has better moisturizing effect and obvious barrier protection effects at the concentration of 300μg/mL.Expression level of type I collagen increases with the increase of the V_(C)-HA concentration in the range of 100~6,250μg/mL.In conclusion,a certain concentration of V_(C)-HA has better moisturizing,barrier protection and firming effects. | Yu Tiantian Guo Kai Lin Mengjun Cui Benwen Wang Huihui Ji Shengli | 2022 | China Detergent & Cosmetics2022，7，3： | 0 |
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