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| 1 | Ultrasound guided percutaneous cholecystostomy in high-risk patients for surgical intervention显示文摘AIM: To assess the efficacy and safety of ultrasound guided percutaneous cholecystostomy (PC) in the treatment of acute cholecystitis in a well-defined high risk patients under general anesthesia. METHODS: The data of 27 consecutive patients who underwent percutaneous transhepatic cholecystostomy for the management of acute cholecystitis from January 1999 to June 2003 was retrospectively evaluated. All of the patients had both clinical and sonographic signs of acute cholecystitis and had comorbid diseases. RESULTS: Ultrasound revealed gallbladder stones in 25 patients and acalculous cholecystitis in two patients. Cholecystostomy catheters were removed 14-32 d (mean 23 d) after the procedure in cases where complete regression of all symptoms was achieved. There were statistically significant reductions in leukocytosis, (13.7 × 103 ± 1.3 × 103 μg/L vs 13 × 103 ± 1 × 103 μg/L, P < 0.05 for 24 h after PC; 13.7 × 103 ± 1.3 × 103 μg/L vs 8.3 × 103 ± 1.2 × 103 μg/L, P < 0.0001 for 72 h after PC), C -reactive protein (51.2 ± 18.5 mg/L vs 27.3 ± 10.4 mg/L, P < 0.05 for 24 h after PC; 51.2 ± 18.5 mg/L vs 5.4 ± 1.5 mg/L, P < 0.0001 for 72 h after PC), and fever (38 ± 0.35℃ vs 37.3 ± 0.32℃, P < 0.05 for 24 h after PC; 38 ± 0.35℃ vs 36.9 ± 0.15℃, P < 0.0001 for 72 h after PC). Sphincterotomy and stone extraction was performed successfully with endoscopic retrograde cholangio-pancreatography (ERCP) in three patients. After cholecystostomy, 5 (18%) patients underwent delayed cholecystectomy without any complications. Three out of 22 patients were admitted with recurrent acute cholecystitis during the follow-up and recoveredwith medical treatment. Catheter dislodgement occurred in three patients spontaneously, and two of them were managed by reinsertion of the catheter. CONCLUSION: As an alternative to surgery, percutan- eous cholecystostomy seems to be a safe method in critically ill patients with acute cholecystitis and can be performed with low mortality and morbidity. Delayed cholecystectomy and ERCP, if needed, can be performed after the acute period has been resolved by percutaneous cholecystostomy. | Huseyin Bakkaloglu Hakan Yanar Recep Guloglu Korhan Taviloglu Fatih Tunca Murat Aksoy Cemalettin Ertekin Arzu Poyanli | 2006 | World Journal of Gastroenterology2006，12，44： | 15 |
| 2 | Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer显示文摘Colorectal cancer(CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC(EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, Mut YH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach. | gulcin tezcan berrin tunca secil ak gulsah cecener unal egeli | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 5 |
| 3 | Single - incision laparoscopic adrenalectomy 显示文摘 | Tunca F Senyur YG Terzioglu T | 2012 | Surg Endosc2012，26，： | 1 |
| 4 | Multiple sourcing and procurement process selection with bidding events显示文摘 | Tunca T I Wu Qiong | | 0，，05： | 1 |
| 5 | 1 Diagnostic value of dynamic contrast medium-enhanced magnetic resonance ima- ging in preoperative detection of thyroid carcinoma 显示文摘 | Tezelman S Giles Y Tunca F eta | 2007 | Arch Surg2007，142，： | 1 |
| 6 | Single-incision laparoscopic adrenalectomy显示文摘 | Tunca F Senyurek Y G Terzioglu T | 2012 | Surgical Endoscopy2012，26，： | 1 |
| 7 | Fighting fire with fire:Commercial piracy and the role of file sharing on copyright protection policy for digital goods显示文摘 | Tunca T I Wu Qiong | 2013 | Information System Research2013，24，2： | 1 |
| 8 | The Change in Surgical Practice from Subtotal to Near-Total or Total Thyroidectomy in the Treatment of Patients with Benign Multinodular Goiter显示文摘 | Serdar Tezelman Ismail Borucu Yasemin Senyurek (Giles) Fatih Tunca Tarik Terzioglu | 2009 | World Journal of Surgery2009，，3： | 1 |
| 9 | Diverse glial cell line-derived neurotrophic factor (GDNF) support between mania and schizophrenia: A comparative study in four major psychiatric disorders 显示文摘 | Tunca Z Kivircik Akdede B Ozerdem A | 2015 | Eur Psychiatry2015，30，： | 1 |
| 10 | p53 gene mutations in surgical mains and primary tumor tissues of patients with squamous cell carcinoma of the head and neck显示文摘 | Tunca B Erisen L Coskun H | 2007 | Tumori2007，93，2： | 1 |
| 11 | Single-incision laparo- scopic adrenaleetomy显示文摘 | Tunca F Senyurek Y G Tenioglu T | 2012 | Surg Endose2012，26，： | 1 |
| 12 | Fighting fire with fire: Commercial piracyand the role of file sharing on copyright protection policy for digitalgoods显示文摘 | Tunca T I Wu Qiong | 2013 | Information Systems Research2013，24，2： | 1 |
| 13 | Synthesis of polymers containing crown ether and ferrocene units显示文摘 | Umit Tunca | 1996 | Polymer1996，37，17： | 1 |
| 14 | Chromosomal localization of single copy genes SRY and SOX3 by primed in situ labeling (PRINS)显示文摘 | Kadanadale JS Tunca Y Tharapel AT | 2000 | Microb Comp Genomics2000，5，2： | 1 |
| 15 | Cytogenetic findings on shoe workers exposed long-term to benzene 显示文摘 | Berrin Tunca Unal Egeli | 1996 | Environment Health Perspective1996，104，： | 1 |
| 16 | Vitamin D receptor gene polymorphisms are not associated with alopecia areata 显示文摘 | Akar A Orkunoglu FE Tunca M | 2007 | Int J Dermatol2007，46，9： | 1 |
| 17 | Localization of SRY by primed in situ labeling in XX and XY sex reversal显示文摘 | Kadanadale JS Wachtel SS Tunca Y | 2000 | Am J Med Genet2000，95，1： | 1 |
| 18 | Cyclic fatigue of ProTaper rotary nickel-titanium instruments in artificial canals with 2 different radii of curvature显示文摘 | Inan U Aydin C Tunca YM | | 0，，06： | 1 |
| 19 | Mutation in the thyroid hormone receptor (TR) beta gene ( M313T) not previously re- ported in two unrelated families with resist- ante to thyroid hormone (RTH) 显示文摘 | Refetoff S Tunca H Wilansky DL | 1996 | Thy- roid1996，6，6： | 1 |
| 20 | Multiple sourcing and procurement process selection with bidding events显示文摘 | Tunca T I Wu Q | 2009 | Management Science^2009，55，： | 1 |
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