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| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | 关键基础设施及其安全管理显示文摘关键基础设施(CI)系统是复杂的、高度相互依存的、网络化的社会—技术系统,一旦系统被中断或者被破坏,将会对国民健康、国土安全、经济稳定以及政府的正常运转等产生重大的影响.主要研究关键基础设施及其安全管理过程中的若干问题,对CI的特点进行了分析和总结,建立了网络化CI系统的体系结构,并利用视图模型来描述系统,同时还给出了灾难处理的一般过程.最后,进一步探讨了如何使用系统工程的方法来分析和模拟网络化CI系统的运行方式、潜在的薄弱环节以及改进这些薄弱环节的实施方法. | 刘晓 张隆飙 Zhang W J Tu Y L | 2009 | 管理科学学报2009，12，6： | 22 |
| 3 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 4 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 5 | 基于自动测量的诊室血压高血压诊断标准与心血管病风险显示文摘与血压相关的心血管事件风险很大程度是基于台式水银血压计的人群测量数据。考虑到电子血压计逐步替代台式水银血压计,该研究采用全自动血压计在研究对象独自安静休息时多次读取数据,以探讨导致心血管风险显著增加的血压水平。方法:纳入〉65岁的未经治疗的高血压社区居民3627例。从社区药店和家庭医生获得受试者未受干扰时的坐位自动诊室血压数据。针对致命性及非致命性心血管事件,受试者随访(4.9±1.0)年。 | Myers MG Kaczorowski J Paterson JM Dolovich L Tu K 赵狄 练桂丽 | 2015 | 中华高血压杂志2015，23，8： | 3 |
| 6 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 7 | Research on Service Life Prediction Model of Concrete Structure of Sea-crossing Bridge显示文摘According to the chloride corrosion environment,service life prediction model of concrete structure of sea-crossing bridge was built using modified Fick's second law and the whole probability calculation method,which was suitable for China. Furthermore,a visual service life prediction program of concrete structure was developed by optimized Monte Carlo method. Meanwhile,Life 365 program was compared,indicating reliability of the prediction program. Finally,the validity of prediction model was verified in JinTang Bridge of Zhoushan Island Mainland Linkage Project. | WANG C J ZHANG G Z LIU K X TU L Q LI J H QIN M Q | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 8 | Hydrogen storage characteristics of Ti 2 Ni alloy synthesized by the electro-deoxidation technique显示文摘 | Mustafa Anik Bedri Baksan Tu?ba ?l?er Orbay Nilüfer Kü?ükdeveci Alanur Binal Aybar Re?at Can ?zden Hakan Ga?an Nur?en Ko? | 2014 | Intermetallics2014，，： | 2 |
| 9 | Clinical and dermoscopic features of surgically treated melanocytic nevi: a retrospective study of 1046 cases显示文摘Background: Compared with Caucasians, unique demographic and clinical features have been reported in Chinese patients with malignant melanoma, but similar comparative studies of melanocytic nevi (MN) are lacking. This study examined the clinical and dermoscopic features of MN in surgically treated Chinese cases. Methods: Clinical data and dermoscopic findings from 1046 cases of MN were collected and analyzed. Cases were treated from January 1 to December 31, 2014 at the Department of Dermatology and Venerology, Peking University First Hospital. The association between nevi location and histologic subtypes was examined with Chi-squared test and univariate logistic regression. Chi-squared test was also used to analyze the proportion of globular patterns across different body sites, and proportion of parallel furrow patterns across different histologic subtypes. Results: The majority of the nevi were from female patients, irrespective of location. The range of age at the time of nevi onset was from 0 (birth) to 79 years. There were 381 (36.4%, 381/1046) congenital nevi;of these 81.6%(311/381) were present at birth. Nevi appeared before 30 years of age in 83.2%(870/1046) of the cases. Median values of length growth rate in congenital and acquired MN were 2.0 and 1.6, respectively. Median values of length growth rates in four age groups (0–9, 10–19, 20–29, and ≥30 years) of congenital nevi were 2.2, 2.0, 2.4, and 2.0, respectively. In acral nevi, which often need to be differentiated from acral lentiginous melanoma, 50.2%(109/217) were junctional (odds ratio [OR];95% confidence interval [CI]: 91.572 [52.210–160.959], P < 0.05). Acral location was also associated with a higher likelihood of compound nevi subtype (OR [95% CI]: 14.468 [8.981–23.306], P < 0.05). The globular (59.4%, 354/596) and pseudonetwork (48.8%, 291/596) dermoscopic patterns were often seen in the head and neck region. In areas other than head and neck and acral regions, the globular pattern was the commonest pattern (34.8%, 71/204) regardless of age. Parallel furrow pattern occurred in 46.0%(87/189) of acral MN, followed by fibrillar pattern (21.7%, 41/189). Conclusion: Unique clinical and dermoscopic features exist in Chinese patients with MN compared with observations reported in other population. | Qian-Xi Li David L Swanson Ping Tu Shu-Xia Yang Hang Li | 2019 | Chinese Medical Journal2019，，17： | 2 |
| 10 | A fern that hyperaccumulates arsenic显示文摘 | Ma L Q Kenneth M K Tu C | 2001 | Nature2001，409，6820： | 1 |
| 11 | Symptom improvement in lung cancer patients treated with erlotinib:Quality of life analysis of the National Cancer Institute of Cannda Clinical Trials Group Study BR21显示文摘 | Bezjak A Tu D Seymour L | 2006 | J Clin Oncol2006，24，24： | 1 |
| 12 | Regulation of adrenal glucocorticoid synthesis by interleukin-10:a preponderance of IL10 receptor in the adrenal zona fasciculata 显示文摘 | Nina Koldzic-Zivanovic Huolin Tu Terry L | 2006 | Brain Behavior and Immunity2006，20，8： | 1 |
| 13 | The effect of sodium nitrite on the textural properties of cooked sausage during cold storage显示文摘 | Dong Q Tu K Guo L | 2007 | Journal of Texture Studies2007，38，5： | 1 |
| 14 | Impact of interleukin-6 on hypoxia- induced pulmonary hypertension and lung inflammation in mice 显示文摘 | Savale L Tu L Rideau D | 2009 | Respir Res2009，10，1： | 1 |
| 15 | A fem that hyperaccumulates arsenic显示文摘 | Ma L Q Komar K M Tu C Zhang W H Cai Y Kennelley E D | 2001 | Nature2001，409，： | 1 |
| 16 | Exergy-based eco- logical optimization for an endoreversible Brayton refrigeration cycle 显示文摘 | TU Y CHEN L SUN F | 2006 | Int J Exergy2006，3，2： | 1 |
| 17 | Comparison of spectral and image morphological analysis for egg early hatching propertydetection based on hyperspectral imaging 显示文摘 | Zhang W Pan L Q Tu K | 2014 | Plos ONE2014，9，2： | 1 |
| 18 | Distribution Characteristics of Vehicle Specific Power on Urban Restricted Access Roadways 显示文摘 | Song G L Yu Z Tu | 2012 | Journal of Transportation Engineering (S0733-947X) ASCE2012，138，： | 1 |
| 19 | Arbuscular mycorrhizal fungi increase organic carbon decomposition under elevated CO2显示文摘 | Cheng L Booker FL Tu C Burkey KO Zhou LS Shew HD Rufty TW Hu SJ | | 0，，： | 1 |
| 20 | Learning Gaussian mixture with automatic model selection:A comparative study on three Bayesian related approaches显示文摘 | Shi L Tu S K Xu L | | 0，，02： | 1 |
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