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| 1 | Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients显示文摘AIM:To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colorectal cancer (mCRC) patients. METHODS:Forty-three patients with mCRC treated with cetuximab or panitumumab were entered into this study. According to the Response Evaluation Criteria in Solid Tumors criteria, 30 patients had stable or progressive disease (non-responsive), while 13 patients had a partial response. Tumor buds were evaluated from whole tissue sections stained for pan-cytokeratin, evaluated in the densest region using a 40 × objective and 'high-grade' tumor budding was defi ned as 15 buds/high-power f ield.RESULTS: Tumor buds and K-RAS mutation both correctly classif ied 68% of patients. All patients with K-RAS mutation (n=7) or high-grade tumor budding (n=11) were non-responsive, of which 4 patients had both features. All 13 partial responders were K-RAS wild-type with low-grade tumor budding. Combined, the predictive value of K-RAS and tumor budding was 80%. Additionally, high-grade tumor budding was significantly related to worse progression-free survival [HR (95% CI): 2.8 (1.3-6.0, P=0.008)].CONCLUSION: If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting. | Inti Zlobec Francesca Molinari Vittoria Martin Luca Mazzucchelli Piercarlo Saletti Rosangela Trezzi Sara De Dosso Tatjana Vlajnic Milo Frattini Alessandro Lugli | 2010 | World Journal of Gastroenterology2010，16，38： | 4 |
| 2 | Performance of Eu- roSCORE in CABG and off-pump coronary artery bypass grafting: single institution experience and meta-analysis 显示文摘 | Parolari A Pesce LL Trezzi M | 2009 | Eur Heart J2009，30，3： | 1 |
| 3 | Performance of EuroSCORE in CABG and off- pump coronary artery bypass grafting: single institu- tion experience and meta- analysis显示文摘 | Parolari A Pesce LL Trezzi M | 2009 | Eur Heart J2009，30，3： | 1 |
| 4 | Performance of EuroSCORE in CABG and off pump coronary artery bypass grafting: single insti- tution experience and meta analysis 显示文摘 | Parolari A Pesce L Trezzi M | 2009 | Eur Heart J2009，30，3： | 1 |
| 5 | EuroSCORE performance in valve surgery : a meta-analysis显示文摘 | Parolari A Pesce LL Trezzi M | 2010 | Ann Thorac Surg2010，89，1： | 1 |
| 6 | EuroSCORE performance in valve surgery : a meta-analysis 显示文摘 | Parolari A Pesce LL Trezzi M | 2010 | Ann Thorac Surg2010，89，3： | 1 |
| 7 | Rituximab vs myeophenolate and vs eyclophosphamide pulses for induction therapy of active lupus nephritis: a clinical observational study 显示文摘 | Moroni G Raffiotta F Trezzi B | 2014 | Rheumatology (Oxford)2014，53，9： | 1 |
| 8 | Performance of EuroSCORE in CABG and off-pump coronary artery bypass grafting,single in- stitution experience and meta-analysis 显示文摘 | Parolari A Pesce LL Trezzi M | 2009 | Eur Heart J2009，30，： | 1 |
| 9 | Performance of EuroSCORE in CABG and off-pump coronary artery bypass grafting:single institution experience and meta-analysis显示文摘 | Parolari A Pesce LL Trezzi M | 2009 | Eur Heart J2009，30，3： | 1 |
| 10 | Statin therapy is associated with fewer infections after cardiac operations显示文摘 | Trezzi M Blackstone EH Sun Z | 2013 | Ann Thorac Surg2013，95，3： | 1 |
| 11 | EuroSCORE performance in valve surgery:a meta-analysis显示文摘 | Parolari A Pesce LI Trezzi M | | 0，，： | 1 |
| 12 | Clinical usefulness of autoanti- bodies to M-type phospholipase A2 receptor(PLA2R) for monitoring disease activity in idiopathic membranous nephropathy (IMN) 显示文摘 | Radice A Trezzi B Maggiore U | 2016 | Autoimmun Rev2016，15，2： | 1 |
| 13 | EuroSCORE performance in valve surgery:a meta-analysis显示文摘 | Parolari A Pesce LL Trezzi M | 2010 | Ann Thorac Surg2010，89，3： | 1 |
| 14 | Air pollutants emissions estimate from maritime traffic in the Italian harbours of Venice and Piombino显示文摘 | Trezzi C Vaccaro R Nicolo L | 1995 | Science of the Total Environment1995，169，13： | 1 |
| 15 | Performance of EuroSCORE in CABG and off-pump coronary artery bypass grafting:single institution experience and meta-analysis显示文摘 | Parolari A Pesce L L Trezzi M Loardi C Kassem S Brambillasca C | 2009 | Eur Heart J2009，30，： | 1 |
| 16 | EuroSCORE performance in valve surgery:a meta-analysis显示文摘 | Parolari A Pesce LL Trezzi M | 2010 | Ann Thorac Surg2010，89，3： | 1 |
| 17 | Rituximab vs myco- phenolate and vs cyclophosphamide pulses for induction thera- py of active lupus nephritis: a clinical observational study显示文摘 | Moroni G Raffiotta F Trezzi B | 2014 | Rheumatology (Oxford)2014，53，9： | 1 |
| 18 | Lung ultrasonography for the assessment of rapid extravascular water variation: evidence from, hemodialysis patients显示文摘 | Trezzi M Torzillo D Ceriani E | 2013 | Intern Emerg Med2013，8，5： | 1 |
| 19 | New additives to offer freeze–thaw stability and increase open time of low/zero VOC latex paints显示文摘 | Zhengang Zong Sarah Wall Yi-Zhong Li Jose Ruiz Herve Adam Chantal Badre Fabio Trezzi | 2011 | Progress in Organic Coatings2011，，1： | 1 |
| 20 | Lung ultrasonography for theassessment of rapid extravascular water variation : evidence fromhemodialysis patients 显示文摘 | Trezzi M Torzillo D Ceriani E | 2013 | Intern Emerg Med2013，8，5： | 1 |
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