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| 1 | Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes显示文摘Patients with inflammatory bowel disease(IBD)have an increased risk of 10%-15%developing colorectal cancer(CRC)that is a common disease of high economic costs in developed countries.The CRC has been increasing in recent years and its mortality rates are very high.Multiple biological and biochemical factors are responsible for the onset and progression of this pathology.Moreover,it appears absolutely necessary to investigate the environmental factors favoring the onset of CRC and the promotion of colonic health.The gut microflora,or microbiota,has an extensive diversity both quantitatively and qualitatively.In utero,the intestine of the mammalian fetus is sterile.At birth,the intestinal microbiota is acquired by ingesting maternal anal or vaginal organisms,ultimately developing into a stable community,with marked variations in microbial composition between individuals.The development of IBD is often associated with qualitative and quantitative disorders of the intestinal microbial flora(dysbiosis).The healthy human gut harbours about10 different bacterial species distributed in colony forming units which colonize the gastrointestinal tract.The intestinal microbiota plays a fundamental role in health and in the progression of diseases such as IBD and CRC.In healthy subjects,the main control of intestinal bacterial colonization occurs through gastric acidity but other factors such as endoluminal temperature,competition between different bacterial strains,peristalsis and drugs can influence the intestinal microenvironment.The microbiota exerts diverse physiological functions to include:growth inhibition of pathogenic microorganisms,synthesis of compounds useful for the trophism of colonic mucosa,regulation of intestinal lymphoid tissue and synthesis of amino acids.Furthermore,mucus seems to play an important role in protecting the intestinal mucosa and maintaining its integrity.Changes in the microbiota composition are mainly influenced by diet and age,as well as genetic factors.Increasing evidence indicates that dysbiosis favors the production of genotoxins and metabolites associated with carcinogenesis and induces dysregulation of the immune response whichpromotes and sustains inflammation in IBD leading to carcinogenesis.A disequilibrium in gut microflora composition leads to the specific activation of gut associated lymphoid tissue.The associated chronic inflammatory process associated increases the risk of developing CRC.Ulcerative colitis and Crohn’s disease are the two major IBDs characterized by an early onset and extraintestinal manifestations,such as rheumatoid arthritis.The pathogenesis of both diseases is complex and not yet fully known.However,it is widely accepted that an inappropriate immune response to microbial flora can play a pivotal role in IBD pathogenesis. | Giovanni Tomasello Pietro Tralongo Provvidenza Damiani Emanuele Sinagra Benedetto Di Trapani Marie Noelle Zeenny Inaya Hajj Hussein Abdo Jurjus Angelo Leone | 2014 | World Journal of Gastroenterology2014，20，48： | 10 |
| 2 | Efficacy and Safety of Cetuximab/Irinotecan in Chemotherapy-Refractory Metastatic Colorectal Adenocarcinomas: A Clinical Practice Setting, Multicenter Experience显示文摘 | Vittorio Gebbia Salvatore Del Prete Nicoló Borsellino Francesco Ferraú Paolo Tralongo Francesco Verderame Vita Leonardi Elena Capasso Evaristo Maiello Roberto Bordonaro Sergio Stinco Biagio Agostara Carlo Barone | 2006 | Clinical Colorectal Cancer2006，，6： | 1 |
| 3 | Hepatitis C Virus Core Antigen Test in Monitoring of Dialysis Patients显示文摘 | Gioacchino Li Cavoli Carmela Zagarrigo Onofrio Schillaci Francesca Servillo Angelo Tralongo Mario Coglitore Filippo Spadaro Concetta Scimeca Natalia Li Destri Ugo Rotolo Mikio Zeniya | 2012 | Hepatitis Research and Treatment2012，，： | 1 |
| 4 | Cancer patient-centered home eare:a new model for health care in oncology 显示文摘 | IPaolo Tralongo Francesco Ferrau Nicolo Borsellino | 2011 | Therapeutics and Clinical Risk Management2011，7，： | 1 |
| 5 | Safety of long-term administration of bisphosphonates in elderly cancer patients显示文摘 | Tralongo P Repetto L Di Mari A | 2004 | Oncology2004，67，2： | 1 |
| 6 | Optimal sequence of bone target drugs in metastatic prostatic cancer显示文摘 | Gemone A Bordonaro S Tralongo P | 2015 | Expert Rev Anticancer Ther2015，15，8： | 1 |
| 7 | Safety of long-term administration of bisphosphonates in elderly cancer patients显示文摘 | Tralongo P Repetto L Marl A | 2004 | Oncology2004，67，3： | 1 |
| 8 | Pleomorphic adenma and adenoid cysticcarcinoma of salivary gland immuno-histochemical assessment of proliferative activity in comparison with flow cytometric study显示文摘 | Daniele E Tralongo V Morello V | 1996 | Cell Prolif1996，29，： | 1 |
| 9 | Evolution of sequential bortezomib-dexamethasone treatment followed by autologous hematopoietic stem cell transplantation in hemodialysis treatment显示文摘 | Li Cavoli Gioacchino Zagarrigo Carmela Servillo Franca Coglitore Mario Schillaci Onofrio Tralongo Angelo Rotolo Ugo | 2013 | Chinese Medical Journal2013，，9： | 0 |
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