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| 1 | Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention显示文摘Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carcinogens within the intestinal lumen and to promote healthy gut microbiota, which modifies the host's metabolism in various ways. Elucidation of the mechanisms by which dietary fiber-dependent changes in gut microbiota enhance bile acid deconjugation, produce short chain fatty acids, and modulate inflammatory bioactive substances can lead to a better understanding of the beneficial role of dietary fiber. This article reviews the current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer. | Huawei Zeng Darina L Lazarova Michael Bordonaro | 2014 | World Journal of Gastrointestinal Oncology2014，6，2： | 19 |
| 2 | CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer显示文摘This paper reviews the distinctive roles played by the transcriptional coactivators CREB-binding protein(CBP) and p300 in Wnt/β-catenin signaling and cell physiology in colorectal cancer(CRC). Specifically, we focus on the effects of CBP- and p300-mediated Wnt activity on(1) neoplastic progression;(2) the activities of butyrate, a breakdown product of dietary fiber, on cell signaling and colonic cell physiology;(3) the development of resistance to histone deacetylase inhibitors(HDACis), including butyrate and synthetic HDACis, in colonic cells; and(4) the physiology and number of cancer stem cells. Mutations of the Wnt/β-catenin signaling pathway initiate the majority of CRC cases, and we have shown that hyperactivation of this pathway by butyrate and other HDACis promotes CRC cell apoptosis. This activity by butyrate may in part explain the preventive action of fiber against CRC. However, individuals with a high-fiber diet may still develop neoplasia; therefore, resistance to the chemopreventive action of butyrate likely contributes to CRC. CBP or p300 may modify the ability of butyrate to influence colonic cell physiology since the two transcriptional coactivators affect Wnt signaling, and likely, its hyperactivation by butyrate. Also, CBP and p300 likely affect colonic tumorigenesis, as well as stem cell pluripotency. Improvement of CRC prevention and therapy requires a better understanding of the alterations in Wnt signaling and gene expression that underlie neoplastic progression, stem cell fate, and the development of resistance to butyrate and clinically relevant HDACis. Detailed knowledge of how CBP- and p300 modulate colonic cell physiology may lead to new approaches for anti-CRC prevention and therapeutics, particularly with respect to combinatorial therapy of CBP/p300 inhibitors with HDACis. | Michael Bordonaro Darina L Lazarova | 2015 | World Journal of Gastroenterology2015，21，27： | 6 |
| 3 | Low-dose enalapril in the treatment of surgical cutaneous hypertrophic scar and keloid-two case reports and literature review显示文摘 | Iannello S Milazzo P Bordonaro F | 2006 | MedGenMed2006，8，： | 1 |
| 4 | Goat milk with different αa2-casein content: Analysis of allergenic potency by REAST-inhibition assay 显示文摘 | Marietta D Bordonaro S Guastella A M | 2004 | Small Rumin ant Res2004，52，： | 1 |
| 5 | Donkeys, milk protein fraction investigated by electrophoretic methods and mass spectrometric analysis显示文摘 | CRISCIONE A CUNSOLO V BORDONARO S | 2009 | International Dairy Journal2009，19，： | 1 |
| 6 | 膳食纤维、肿瘤干细胞和Wnt信号活性的连续谱:结肠直肠癌预防和治疗的可能性显示文摘Wnt信号转导参与了人类结肠直肠癌(colorectal cancer,CRC)的发生。尽管Wnt信号转导活性与细胞增殖间的关系已经明了,但也有研究表明,高水平的Wnt活性与细胞凋亡间存在关系。我们分析了10种人类CRC细胞系,结果发现组蛋白去乙酰酶抑制剂(inhibitors of histone deacetylases,HDACis),例如丁酸盐,可通过过度诱导Wnt信号转导而促使CRC细胞凋亡;因此,通过HDACis过度活化Wnt信号转导可作为结肠直肠癌新的预防和治疗措施。我们的研究结果可以解释膳食纤维及其产物丁酸盐对于CRC保护作用的研究结果和丁酸盐的抗肿瘤作用为何相互矛盾。我们认为,体外研究中观察到的Wnt活性水平和CRC细胞凋亡水平的变化表明体内存在CRC细胞亚型,它们对于丁酸盐的反应程度不同。Wnt活性与肠道干细胞的更新和CRC干细胞的转移潜能相关,本文在此基础上讨论HDACis介导的Wnt信号转导调节作为CRC干细胞治疗方法的可能性,认为对Wnt阳性的CRC干细胞进行靶向治疗可作为CRC的基因疗法。 | Michael Bordonaro Alan C. Sartorelli | 2008 | 癌症2008，27，7： | 1 |
| 7 | Genetic polymorphism at CSN1S2 locus in two endangered Sicilian goat breeds 显示文摘 | Marietta D Bordonaro S Gusatella A M | 2004 | J Anim Breed Genet2004，121，： | 1 |
| 8 | Pharmacological and genetic modulation of Wnt targeted Cre-Lox-mediated gene expression in colorectal cancer cells 显示文摘 | Bordonaro M Lazarova D L Sartorelli A C | 2004 | Nucleic Acids Res2004，32，8： | 1 |
| 9 | The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors显示文摘 | Michael Bordonaro Darina L. Lazarova Alan C. Sartorelli | 2007 | Experimental Cell Research2007，，8： | 1 |
| 10 | Role of Wnt signaling in the develop-ment of type 2 diabetes显示文摘 | Michael Bordonaro | 2009 | Vitam Horm2009，80，： | 1 |
| 11 | Goat milk with different αs2-casein content: analysis of allergenic potency by REAST- inhibition assay 显示文摘 | Marietta D Bordonaro S Guastella A M | 2004 | Small Ruminant Research2004，52，： | 1 |
| 12 | The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors显示文摘 | Bordonaro M Lazarova DL Sartorelli AC | | 0，，08： | 1 |
| 13 | Decor- related unbiased converted measurement Kalman filter显示文摘 | BORDONARO S WILLETT P BAR-SHALOM Y | 2014 | IEEE Transactions on AES2014，50，2： | 1 |
| 14 | Active home-based cancer treatment显示文摘 | Bordonaro S Raiti F Di Marl A | 2012 | J Multidiscip Healthc2012，5，： | 1 |
| 15 | Effect of a structured, active, home-based cancer-treatment program for the management of patients on oral chemotherapy 显示文摘 | Bordonaro S Romano F Lanteri E | 2014 | PATIENT PREFER ADHER2014，8，： | 1 |
| 16 | Capecitabine in combination with oxaliplatin or irinotecan in elderly patients with advanced colorectal cancer:results of a randomized phase II study显示文摘 | Rosati G Cordio S Bordonaro R | 2010 | Ann Oncol2010，21，4： | 1 |
| 17 | Efficacy and safety of zoledronic acid in patients with breast cancer metastatic to bone: a muhicenter clinical trial显示文摘 | Carteni G Bordonaro R Giotta F | 2006 | Oncologist2006，11，7： | 1 |
| 18 | Efficacy and Safety of Zole-dronic Acid in Patients with Breast Cancer Metastatic to Bone:A Mul-ticenter Clinical显示文摘 | Carteni G Bordonaro R Giotta F | 2006 | The oncologist2006，11，： | 1 |
| 19 | The Notch ligand Delta-like 1 integrates inputs from TGF-beta/Activin and Wnt pathways显示文摘 | Bordonaro M Tewari S Atamna W | 2011 | Exp Cell Res2011，317，10： | 1 |
| 20 | Efficacy and safety of zoledronic acid inpatients with breast cancer metastatic to bone:a multicenter clinical trial显示文摘 | Carteni G Bordonaro R Giotta F | | 0，，： | 1 |
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