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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | Orthogonal defect classification - A concept for in-process measurements 显示文摘 | CHILLAREGE R BHANDARI I CHAAR J | 1992 | IEEE Transactions on Software Engineering1992，18，11： | 1 |
| 3 | Defect Classification-A Concept for Inprocess Measurements 显示文摘 | Chillarege R Bhandari I Chaar J | 1992 | IEEE Transactions on Software Engineering1992，18，11： | 1 |
| 4 | p73 gene expression in colorectal adenocarcinoma: a prognostic or etiopathogenetic factor?显示文摘 | Ben Mahmoud LK Toumi AA Chaar I | 2009 | Tunis Med2009，87，： | 1 |
| 5 | Orthogonal Defect Classification: A Concept for In--Process Measurements 显示文摘 | CHILLAREGE R BHANDARI I S CHAAR J K | 1992 | IEEE Transac- tions on Software Engineering1992，18，11： | 1 |
| 6 | Biological significance of promoter hypermethylation of pl4/ARF gene: Relationships to p53 mutational status in Tunisian population with colorectal carcinoma 显示文摘 | Chaar I Amara S Elamine OE | 2013 | Tumor Biol2013，11，5： | 1 |
| 7 | Biological significance of promoter hypermethylation of pl4/ARF gene: relationships to p53 mutational status in Tunisian population with eolorectal carcinoma显示文摘 | Chaar I Amara S Elamine OE | 2014 | Tumour Biol2014，35，2： | 1 |
| 8 | Impact of M-DM2 polymorphism : in- creased risk of developing colorectal cancer and a poor prognosis in the Tunisian population 显示文摘 | Chaar I Arfaoui TA Aminel HO | 2012 | Eur J Gastroenterol Hepatol2012，24，3： | 1 |
| 9 | Expanding the role of endovenous laser therapy: results in tarse diameter saphenous, small saphenous and anterior accessory veins显示文摘 | Chaar C I Hirsch S A Cwenar M T | 2011 | Ann Vase Surg2011，25，5： | 1 |
| 10 | Angiotensin receptor blockade decreases fibrosis and fibroblast expression in a rat model of unilateral ureteral obstruction显示文摘 | Kellner D Chen J Richardson I Seshan S V El Chaar M Vaughan E D Jr | 2006 | J Urol2006，176，： | 1 |
| 11 | Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis显示文摘 | Amara S Chaar I Khiari M | 2015 | Cancer Biomark2015，15，6： | 1 |
| 12 | Orthogonal Defect Classification A Concept for In-process Measurements显示文摘 | Chillarege R Bhandari I S Chaar J K | 1992 | IEEE Transactions on Software Engineering1992，18，11： | 1 |
| 13 | Impact of M-DM2 polymorphism:increased risk of developing colorectal cancer and a poor prognosis in the Tunisian population显示文摘 | Chaar I Arfaoui TA Aminel HO | | 0，，03： | 1 |
| 14 | Orthogonal Defect Classification-A Concept for Inprocess Measurements显示文摘 | Chillarege R Bhandari I S Chaar J K | 1992 | IEEE Transaction on Software Engineering1992，18，11： | 1 |
| 15 | Orthogonal Defect Classitlcation-A Concept for In-process Measurements显示文摘 | Ram Chillarege I Bhandari J Chaar | 1992 | IEEE Transactions on Software Engineering1992，18，11： | 1 |
| 16 | Orthogonal Defect Classification : A Concept for Inprocess Measurements显示文摘 | CHILLAREGE R BHANDARI I S CHAAR J K | 1992 | IEEE Transaction on Software Engineering1992，18，11： | 1 |
| 17 | Orthogonal defect classification: a concept for in-process measurements 显示文摘 | Chillarege R Bhandari I S Chaar J K | 1992 | IEEE Transactions onSoftware Engineering1992，18，11： | 1 |
| 18 | Orthogonal defect classification: a concept for in-process measurements 显示文摘 | CHILLAREGE R BHANDARI I CHAAR J | 1992 | IEEE Trans on Software Engineering1992，18，11： | 1 |
| 19 | Orthogonal defect cl assification-a concept for in-process measurements显示文摘 | Chillarege R Bhandari I Chaar J | 1992 | IEEE Trans Software Eng1992，18，11： | 1 |
| 20 | Orthogonal defect classification a concept for in-process measurements显示文摘 | Chillarege R Bhandari I S Chaar J K | 1992 | IEEE Transactions on Software Engineering1992，18，11： | 1 |
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