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| 1 | Therapeutic and clinical aspects of portal vein thrombosis in patients with cirrhosis显示文摘Portal vein thrombosis(PVT) is a frequent complication in cirrhosis, particularly in advanced stages of the disease. As for general venous thromboembolism, risk factors for PVT are slow blood flow, vessel wall damage and hypercoagulability, all features of advanced cirrhosis. Actually, the old dogma of a hemorrhagic tendency in cirrhosis has been challenged by new laboratory tools and the clinical evidence that venous thrombosis also occurs in cirrhosis. The impaired hepatic synthesis of both pro- and anticoagulants leads to a rebalanced hemostasis, more liable to be tipped towards thrombosis or even bleeding. Conventional anticoagulant drugs(low molecular weight heparin or vitamin K antagonists) may be used in cirrhosis patients with PVT, particularly in those eligible for liver transplantation, to prevent thrombosis progression thus permitting/facilitating liver transplant. However, several doubts exist on the level of anticoagulation achieved as estimated by coagulation tests, on the efficacy of treatment monitoring and on the correct timing for discontinuation in non-transplant candidates, while in transplant candidates there is expert consensus on continuing anticoagulation until transplantation. The recent introduction of direct acting oral anticoagulant drugs(DOACs) in other clinical settings generates much interest on their possible application in patients with cirrhosis and PVT. However, DOACs were not evaluated yet in patients with liver disease and cannot be recommended for the present time. | Massimo Primignani Giulia Tosetti Vincenzo La Mura | 2015 | World Journal of Hepatology2015，7，29： | 13 |
| 2 | Cirrhosis and portal hypertension: The importance of risk stratification, the role of hepatic venous pressure gradient measurement显示文摘Portal hypertension is the main prognostic factor in cirrhosis. The recent emergence of potent antiviral drugs and new algorithm of treatment for the management of complications due to portal hypertension have sensibly changed our perception of cirrhosis that can be now considered as a multistage liver disease whose mortality risk can be reduced by a tailored approachfor any stage of risk. Experts recommend to move toward a pathophysiological classification of cirrhosis that considers both structural and functional changes. The hepatic venous pressure gradient HVPG, is the reference gold standard to estimate the severity of portal hypertension in cirrhosis. It correlates with both structural and functional changes that occur in cirrhosis and carries valuable prognostic information to stratify the mortality risk. This article provides a general overview of the pathophysiology and natural course of cirrhosis and portal hypertension. We propose a simplified classification of cirrhosis based on low, intermediate and high mortality stage. The prognostic information provided by HVPG is presented according to each stage. A comparison with prognostic models based on clinical and endoscopic variables is discussed in order to evidence the additional contribute given by HVPG on top of other clinical and instrumental variables widely used in clinical practice. | Vincenzo La Mura Antonio Nicolini Giulia Tosetti Massimo Primignani | 2015 | World Journal of Hepatology2015，7，4： | 10 |
| 3 | Use of non-selective beta blockers in cirrhosis:The evidence we need before closing(or not) the window显示文摘Non selective beta blockers(NSBBs)are used in primary and secondary prophylaxis of portal hypertensionrelated bleeding in patients with cirrhosis.The efficacy of NSBBs treatment is predicted by hemodynamic response in term of reduction of the hepatic venouspressure gradient(HVPG)below 12 mm Hg or at least20%of the basal value.Nevertheless a relevant number of patients who do not achieve this HVPG reduction during NSBBs therapy do not bleed during follow up;this evidence suggests an additional non-hemodynamic advantage of NSBBs treatment to modify the natural history of cirrhosis.Recent studies have questioned the efficacy and safety of NSBBs in patients with advanced stage of liver disease characterized by refractory ascites and/or spontaneous bacterial peritonitis.These studies have suggested the existence of a defined and limited period to modify the natural history of cirrhosis by NSBBs:the'window hypothesis'.According with this hypothesis,patients with cirrhosis benefit from the use of NSBBs from the appearance of varices up to the development of an advanced stage of cirrhosis.Indeed,in patients with refractory ascites and/or spontaneous bacterial peritonitis the hemodynamic effects of NSBBs may expose to a high risk of further complications such as renal insufficiency and/or death.Methodological concerns and contrasting results counterbalance the evidence produced up to now on this issue and are the main topic of this editorial. | Vincenzo La Mura Giulia Tosetti Massimo Primignani Francesco Salerno | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 4 | Proteomics-based identification of anchorless cell wall proteins as vaccine candidates against Staphylococcus aureus显示文摘 | Glowalla E Tosetti B Krenke M | 2009 | Infect Immun2009，77，7： | 1 |
| 5 | Proton MR spectroscopy o' the brain at 3 T an update显示文摘 | Di Costanzo A Tro]si F Tosetti M | 2007 | Eur Radiol2007，17，7： | 1 |
| 6 | Proton MR spectroscopy of cerebral gliomas at 3 T: spatial heterogeneity, and tumour grade and extent显示文摘 | Alfonso Costanzo Tommaso Scarabino Francesca Trojsi Teresa Popolizio Domenico Catapano Giuseppe M. Giannatempo Simona Bonavita Maurizio Portaluri Michela Tosetti Vincenzo A. d'Angelo Ugo Salvolini Gioacchino Tedeschi | 2008 | European Radiology2008，，8： | 1 |
| 7 | Dyspeptic symp- toms and gastric emptying in the irritable bowel syndrome 显示文摘 | Stanghellini V Tosetti C Barbara G | 2002 | Am J Gastroenterol2002，97，： | 1 |
| 8 | Brain magnetic resonance in the diagnostic evaluation of mitochondrial encephalopathies 显示文摘 | Bianchi MC Sgandurra G Tosetti M | 2007 | Biosci Rep2007，27，： | 1 |
| 9 | Magnetic resonance angiography virtual endoscopy in the assessment of pulmonary veins before radiofrequency ablation procedures for atrial fibrillation显示文摘 | S. Cirillo R. Bonamini F. Gaita Irene Tosetti M. Giuseppe M. Longo F. Bianchi L. Vivalda D. Regge | 2004 | European Radiology2004，，11： | 1 |
| 10 | Peddictor of gastro-paresis in outpatients with uper gastrointestinal symptoms显示文摘 | Tosetti C Stanghellini V Horowitz M | 1999 | Gastroenterology1999，116，： | 1 |
| 11 | Delayed gastric emptying in functional dyspepsia显示文摘 | Vincenzo Stanghellini MD Roberto De Giorgio MD Giovanni Barbara MD Rosanna Cogliandro MD Cesare Tosetti MD Fabrizio Ponti MD Roberto Corinaldesi MD | 2004 | Current Treatment Options in Gastroenterology2004，，4： | 1 |
| 12 | Reversal of fundic atrophy after eradication of Helicobacter pylori显示文摘 | Tucci A Poli L Tosetti C | | 0，，： | 1 |
| 13 | Use of proton pump inhibitors in general practice显示文摘AIM To evaluate the characteristics of the prescription of the proton pump inhibitor drugs(PPI) and the adherence to the indications of the guidelines regulating thereimbursement limitations set forth by the Italian Drug Agency.METHODS Thirty general practitioners(GP) participated in the study, providing data on more than 40000 patients in total. The population was divided into non occasional users of PPI drugs(PPI users) and non-users(PPI non-users) based on evidence of a prescription of at least 3 packs of PPIs in the last 90 d before analysis. The data provided allowed an assessment of compliance with the requirements of eligibility for PPI reimbursement according to the Italian Drug Agency rules, in order to obtain subpopulations which complied or not with the rules. RESULTS Six thousand three hundred and twenty-two patients were found to be PPI users, accounting for 14.9% of the patient population. PPI users were more frequently female, older and more frequently diagnosed with gastroesophageal reflux disease, gastric or duodenal ulcers, arthropathy, heart disease and cancer than the rest of the population. PPI users had more frequently received prescriptions for non-steroidal ant-inflammatory drugs(NSAIDS), acetylsalicylic acid(ASA), oral anticoagulant therapy(OAT) and systemic steroids. PPI reimbursement resulted applicable to 69.3% of the PPI users, but a potential for reimbursement of PPI prescriptions was identified in the non PPI users for the treatment of peptic or reflux disease(8.5%) and for the protection of gastric damage caused by NSAIDS(6.1%). Patients who are potentially eligible for reimbursement are older, diagnosed with arthropathy and heart disease more frequently and most commonly receive NSAID and ASA prescriptions compared with PPI users who do not satisfy eligibility requirements. Patients in whom it was not possible to identify conditions related to prescription suitability were more frequently associated with use of OAT. CONCLUSION A substantial number of patients who apparently do not meet prescription suitability conditions can be identified, but among non PPI users on the contrary, it is possibleto identify an equal number of patients for whom prescription would be suitable. Poor suitability can be identified in the population receiving OAT. Thus, there is scope for decreasing inappropriate use of PPI drugs by adhering to certain criteria and by involving all interested parties. | Cesare Tosetti Ilaria Nanni | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，3： | 1 |
| 14 | Angioprevention: angiogenesis is a common and key target for cancer chemopreventive agents 显示文摘 | Tosetti F Ferrari N De Flora S | 2002 | FASEB2002，16，1： | 1 |
| 15 | Choking hypoxia-inducible factor 1alpha:a novel mechanism for connective tissue growth factor inhibition of angiogenesis显示文摘 | Tosetti F Noonan DM Albini A | | 0，，： | 1 |
| 16 | Antagonistic action of siderophores from Rhodotorula glutinis upon the postharvest pathogen Penicillium expansum 显示文摘 | Calvente V Benuzzi D Sanz de Tosetti M I | 1999 | International Biodeterioration and Biodegredation1999，43，4： | 1 |
| 17 | Gastric emptying and dyspeptic symptoms in patients with nonautoimmune fundic atrophic gastric 显示文摘 | Tosetti C Stanghellini V Tucci A | 2000 | Dig Dis Sci2000，5，： | 1 |
| 18 | Large Panels with Common Factors and Spatial Correlation显示文摘 | Pesaran M. H Tosetti E | | 0，，02： | 1 |
| 19 | Gastric emptying and dyspeptic symptoms in patients with nonautoimmune fundic atrophic gastritis显示文摘 | Stanghellini V Tucci A | 2000 | Dig Dis Sci2000，45，2： | 1 |
| 20 | Control of Botrytis cinerea strains resistant to iprodione in apple with rhodotorulic acid and yeasts 显示文摘 | Gabriela Sansone Irma Rezza Viviana Calvente Delia Benuzzi Maria Isabel Sanz de Tosetti | 2005 | Postharvest Biology and Technology2005，35，： | 1 |
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