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| 1 | Genomic and genetic alterations influence the progression of gastric cancer显示文摘Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed in both types, different genetic pathways have been hypothesized. Genetic and epigenetic events, including 1q loss of heterozygosity (LOH), microsatellite instability and hypermethylation, have mostly been reported in intestinal-type gastric carcinoma and its precursor lesions, whereas 17p LOH, mutation or loss of E-cadherin are more often implicated in the development of diffuse-type gastric cancer.In this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma. | Stefania Nobili Lorenzo Bruno Ida Landini Cristina Napoli Paolo Bechi Francesco Tonelli Carlos A Rubio Enrico Mini Gabriella Nesi | 2011 | World Journal of Gastroenterology2011，17，3： | 17 |
| 2 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 3 | 钢包和中间包内衬耐火材料与碳钢的化学反应显示文摘在有些情况下,对钢产品内部质量的影响并不取决于生产过程中的误操作,而是低估了液态钢水与不同工序中接触到的材料间的化学反应。尤其是在铸锭生产中,这一点尤为明显。讨论了钢包与中间包内衬耐材与普碳钢间发生的化学反应。这些试验涉及高铝质、铝硅质、铝镁尖晶石质耐火材料,研究了它们在液态钢水中形成夹杂物的倾向性。试验结果表明,在钢水—耐材接触面上会产生一个富含MnO的新相,这一新相的量与二氧化硅在耐材中的活性及锰在钢液里的活性成正比。试验还表明,由液态钢水与耐火材料相互反应产生的接触面可产生新的外来夹杂物进入钢液中。试验结束后,对钢样中新的夹杂物成分做的分析表明,成分取决于耐材—钢水接触面的组成。因此,不同钢厂应该结合自身生产的钢种产品化学组成来选用耐火材料的化学成分设计。 | F Cirilli A Mazzarano M Tonelli 沈钟铭(译) 职建军(校) | 2012 | 世界钢铁2012，12，4： | 3 |
| 4 | Efficient visible laser emission of GaN laser diode pumped Pr-doped fluoride crystals显示文摘 | F Cornacchia A Di Lieto M Tonelli | 2008 | Opt Express2008，16，15： | 1 |
| 5 | Release characteristics of the non-toxic insect repellant 2-undecanone from its crystalline inclusion compound with α-cyclodextrin显示文摘 | WHANG H S TONELLI A | | 0，，1： | 1 |
| 6 | Synthesis methods of fluorinated polyurethanes(1):Effects on thermal and dynamic-mechanical behaviours显示文摘 | Tonelli C Ajroldi G Turturro A | 2001 | Polymer2001，42，13： | 1 |
| 7 | Er:LiGdF4晶体生长及光谱性能显示文摘采用提拉法生长出掺铒氟化钆锂(Er3+:LiGdF4,Er:LGF)激光晶体。晶体生长工艺参数为:提拉速率为0.16mm/h,晶体转速为3r/min,冷却速率为10℃/h。X射线粉末衍射分析表明:晶体属于四方晶系,白钨矿结构,空间群为I41/a,计算的晶胞参数:a=0.5196nm,c=1.10286nm。晶体的吸收光谱和荧光光谱表明:晶体在659,980nm和1540nm附近的吸收峰较强,其中在1540nm处的吸收截面为1.09×10-20cm2。在激光二极管的532nm波长泵浦下,发射峰分别位于995nm和1530nm附近,其中1530nm处的半高宽为52nm。 | 李春 张莹 张学建 林海 TONELLI M Di LIETO A 王成伟 曾繁明 刘景和 | 2010 | 硅酸盐学报2010，38，10： | 1 |
| 8 | Bone remodeling around implants placed in fresh extraction sockets显示文摘 | Calvo JL Tonelli P Barone A | 2010 | Int J Periodontics Restorative Dent2010，30，6： | 1 |
| 9 | The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma显示文摘 | Slack A Chen Z Tonelli R | 2005 | Proc Natl Acad Sci USA2005，102，3： | 1 |
| 10 | Synthesis methods of fluorinated polyurethanes(2):Effects on morphology and microstructure显示文摘 | Tonelli C Ajroldi G Marigo A | 2001 | Polymer2001，42，24： | 1 |
| 11 | Structural studies of Bombyx mori silk fibroin during regeneration from solutions and wet fiber spinning 显示文摘 | Ha S W Tonelli A E Hudson S M | 2005 | Biomacromolecules2005，6，3： | 1 |
| 12 | Clinical risk im- plications of the CKD Epidemiology Collaboration(CKD- EPI) equation compared with the Modification of Diet in Renal Disease( MDRD) Study equation for estimated GFR 显示文摘 | Matsushita K Tonelli M Lloyd A | 2012 | Am J Kidney Dis2012，60，2： | 1 |
| 13 | Inclusion compounds formed between cyclodextrins and nylon 6显示文摘 | Huang L Allen E Tonelli A E | 1999 | Polymer1999，40，11： | 1 |
| 14 | Dynamics of isolated polycaprolactone chains in their inclusion complexes with cyclodextrins显示文摘 | Lu J Mirau P A Tonelli A E | 2001 | Macromoleeules2001，34，10： | 1 |
| 15 | Carbon nanotube interac- tion with extracellular matrix proteins producing scaffolds for tissue en- gineering 显示文摘 | Tonelli F M Santos A K Gomes K N | 2012 | Int J Nanomediciue2012，7，： | 1 |
| 16 | Phosphate-solubilizing peanut associated bacteria: screening for plant growth-promoting activities显示文摘 | Tania Taurian María Soledad Anzuay Jorge Guillermo Angelini María Laura Tonelli Liliana Ludue?a Dayana Pena Fernando Ibá?ez Adriana Fabra | 2010 | Plant and Soil (-)2010，，1： | 1 |
| 17 | High level of resistance to Aztreonam and Ticarcillin in Pseudomonas aeruginosa isolated from soil of different crops in Brazil显示文摘 | Pitondo Silva A Martins V V Tonelli Fernandes A F | 2014 | Science of the Total Environment2014，473，： | 1 |
| 18 | Synthesis methods of fluorinated polyurethanes (2) : Effect on mor- phology and microstructure显示文摘 | TONELLI C AJROLDI G MARIGO A | 2001 | Polymer2001，42，24： | 1 |
| 19 | 查看详情显示文摘 | Tanaka H Gomez M A Tonelli A E | | 0，，： | 1 |
| 20 | The dissolution and characterization of Bombyx mori silk fibroin in calcium nitrate-methanol solution and the regeneration of films 显示文摘 | Mathur A B Tonelli A Rathke T | 1997 | Biopolymers1997，42，1： | 1 |
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