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| 1 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 2 | The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma显示文摘 | Slack A Chen Z Tonelli R | 2005 | Proc Natl Acad Sci USA2005，102，3： | 1 |
| 3 | Estimating Forest Biomass and Volume Using Airborne Laser Data显示文摘 | Nelson R Krabill W Tonelli J | | 0，，02： | 1 |
| 4 | Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis显示文摘 | Tonelli R Purgato S Camerin C | 2005 | Mol Cancer Ther2005，4，5： | 1 |
| 5 | The limits of evidence-based medicine显示文摘 | TONELLI M R | 2001 | Respir Care2001，46，12： | 1 |
| 6 | p^21WAF1/Cipl is acommon target induced by short - chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate ) inneuroblastoma cells 显示文摘 | Rocchi P Tonelli R Camerin C | 2005 | Oncol Rep2005，13，6： | 1 |
| 7 | Analysis of sequential aliquots of hypertonic saline solution-induced sputum from clinically stable patients with cystic fibrosis 显示文摘 | AITKEN M L GREENE K E TONELLI M R | 2003 | Chest2003，123，： | 1 |
| 8 | Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis with raloxifene显示文摘 | TONELLI F FICARI F VALANZANO R | 2003 | Tumori2003，89，： | 1 |
| 9 | Partial anomalous pulmo- nary venous return in patients with pulmonary hypertension显示文摘 | Sahay S Krasuski R A Tonelli A R | 2012 | J Med Imaging Radiat Oncol2012，56，3： | 1 |
| 10 | p21WAF1/CIP1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid,tributyrin and sodium butyrate) in neuroblastoma cells显示文摘 | Rocchi P Tonelli R Camerin C | 2005 | Oncol Rep2005，13，6： | 1 |
| 11 | p21Waf1/Cip1is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid,tributyrin and sodium butyrate) in neuroblastoma cells显示文摘 | Rocchi P Tonelli R Camerin C | 2005 | Oncol Rep2005，13，6： | 1 |
| 12 | Review of conventional and novel polymerization processes for polyesters 显示文摘 | Pang K Kotek R Tonelli A | 2006 | Prog Polym Sci2006，31，11： | 1 |
| 13 | P21^Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells 显示文摘 | Rocchi P Tonelli R Camerin C | 2005 | Oncol Rep2005，13，6： | 1 |
| 14 | Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis withraloxifene 显示文摘 | Tonelli F Ficari F Valanzano R | 2003 | Tumori2003，89，4： | 1 |
| 15 | Sputum induction as a research tool for sampling the airways of subjects with cystic fibrosis 显示文摘 | HENING N R TONELLI M R PIER M V | 2001 | Thorax2001，56，： | 1 |
| 16 | Invitro biocom-pat- ibility of fluorinated polyurethanes显示文摘 | Guerra R S D LeUi L Tonelli C Trombetta T | 1994 | Journal of Materials Science: Materials in Medicine1994，，5： | 1 |
| 17 | p21Waf1/Cip1 is a common target induced by short chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells显示文摘 | Rocchi P Tonelli R Camerin C | 2005 | Oncol Rep2005，13，6： | 1 |
| 18 | Pulmonary vasodilator testing and use of calcium channel blockers in pulmonary arterial hypertension显示文摘 | TONELLI A R ALNUAIMAT H MUBARAK K | 2010 | Respir Med2010，104，： | 1 |
| 19 | Pharmacological treatment of desmoid tumor in familiar adenomatous polyposis: results of a virtro study 显示文摘 | Tonelli F Valanzano R Brandi ML | 1994 | Surgery1994，115，4： | 1 |
| 20 | Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis 显示文摘 | Tonelli R Purgato S Camerin C | 2005 | Mol Cancer Ther2005，4，5： | 1 |
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