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| 1 | Genomic and genetic alterations influence the progression of gastric cancer显示文摘Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed in both types, different genetic pathways have been hypothesized. Genetic and epigenetic events, including 1q loss of heterozygosity (LOH), microsatellite instability and hypermethylation, have mostly been reported in intestinal-type gastric carcinoma and its precursor lesions, whereas 17p LOH, mutation or loss of E-cadherin are more often implicated in the development of diffuse-type gastric cancer.In this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma. | Stefania Nobili Lorenzo Bruno Ida Landini Cristina Napoli Paolo Bechi Francesco Tonelli Carlos A Rubio Enrico Mini Gabriella Nesi | 2011 | World Journal of Gastroenterology2011，17，3： | 17 |
| 2 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 3 | Comparison of Wirsung-jejunal duct-tomucosa and dunking technique for pancreatojejunostomy after pancreatoduodenectomy显示文摘Pancreato-enteric reconstruction after pancreatoduodenectomy (PD) is still a source of debate because of the high incidence of complications. Among the various types of pancreato-jejunostomies we don’t know yet which is the best in terms of anastomotic failure and related complications rates. Wirsung-jejunal duct-to-mucosa anastomosis (WJ) and 'dunking' pancreato-jejunal anastomosis (DPJ) are the two most used ones worldwide but conflicting results are reported. To determine which is the safer anastomosis and to define when an anastomosis should be preferred, we retrospectively reviewed two groups of patients who underwent WJ or DPJ. METHODS:Twenty-three patients underwent PD with WJ (n=17) with dilated (WJD) (n=9) or not-dilated Wirsung’s duct (WJND) (n=8) or with a DPJ (n=6) over a 3-year period at a single institution. RESULTS: The complications rate was high in all groups of patients (33.3% in WJD, 37.5% in WJND and 66.7% in DPJ). A pancreatic fistula developed in one patient in each group (11. 1% in WJD, 12. 5% in WJND and 16. 7% in DPJ). All these patients were managed conservatively. Anastomotic disruption took place in the WJ patients especially in the WJND group (n=2) compared to the WJD (n=1) (25% vs 11.1%) or DPJ groups (0%) : these three patients required a re-operation. Overall, the anastomotic defects were higher in patients who underwent WJND (37.5%), compared to WJD (22.2%) and to DPJ (16.7%). However, no statistical differences were found among the groups. Delayed gastric emptying (DGE) and total parenteral nutrition (TPN) along with anastomotic defects were responsible for a prolonged hospital stay. CONCLUSIONS:Our results were not able to demonstrate any statistical difference between the two different techniques in preventing anastomotic failure. WJ can represent a valid choice in case of a dilated duct and a firm, fibrotic enlarged gland that could not be properly invaginated in a small jejunal loop. DGE may occur in those patients who experienced an anastomotic failure and required a TPN regimen with a prolonged hospital stay. | Unita di Chirurgia, Dipartimento di Fisiopatologia Clinica (Batignani G, Fratini G, Zuckermann M and Tonelli F) and Dipartimento di Statistica (Bianchini E), Universitd degli Studi di Firenze, Flo rence, Italy | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 9 |
| 4 | A new role for plant R2R3-MYB transcription factors in cell cycle regulation显示文摘 | Eleonora Cominelli Chiara Tonelli | 2009 | Cell Research2009，19，11： | 7 |
| 5 | 慢性肾脏病与人口老龄化显示文摘全球老年人口比例呈现稳步上升趋势,其中低等和中等收入国家的增长速度最为显著。这种人口学方面的改变与社会经济发展和人口寿命延长有关。然而,人口老龄化对医疗体系、劳动市场、公共政策、社会事业和家庭结构等诸多领域具有重要影响。因此,我们需要把握机遇,迎接挑战,积极应对人口老龄化。 | Marcello Tonelli Miguel Riella 张望(翻译) 余学清(审校) | 2014 | 中华肾脏病杂志2014，30，2： | 5 |
| 6 | Chronic kidney disease and the aging population显示文摘'Youth,which is forgiven everything,forgives itself nothing:age,which forgives itself everything,is forgiven nothing.'George Bernard ShawThe proportion of older people in the general population is steadily increasing worldwide,with the most rapid growth in low-and middle-income countries[1].This demographic change is to be celebrated,because it is the consequence of socioeconomic development and better life expectancy.However,population aging also | Marcello Tonelli Miguel Riella | 2014 | 肾脏病与透析肾移植杂志2014，23，1： | 5 |
| 7 | Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome显示文摘AIM:To describe our patients affected with ectopic biliary tree gastrinoma and review the literature on this topic.METHODS:Between January 1992 and June 2012,28 patients affected by duodenopancreatic endocrine tumors in multiple endocrine neoplasia type 1(MEN1)syndrome underwent surgery at our institution.This retrospective review article analyzes our experience regarding seventeen of these patients subjected to duodenopancreatic surgery for Zollinger-Ellison syndrome(ZES).Surgical treatment consisted of duodenopancreatectomy(DP)or total pancreatectomy(TP).Regional lymphadenectomy was always performed.Any hepatic tumoral lesions found were removed during surgery.In MEN1 patients,removal of duodenal lesions can sometimes lead to persistence or recurrence of hypergastrinemia.One possible explanation for this unfavorable outcome could be unrecognized ectopic localization of gastrin-secreting tumors.This study described three cases among the seventeen patients who were found to have an ectopic gastrinoma located in the biliary tree.RESULTS:Seventeen MEN1 patients affected with ZES were analyzed.The mean age was 40 years.Fifteen patients underwent DP and two TP.On histopathological examination,duodeno pancreatic endocrine tumors were found in all 17 patients.Eighty-one gastrinomas were detected in the first three portions of the duodenum.Only one gastrinoma was found in the pancreas.The mean number of gastrinomas per patient was 5(range 1-16).Malignancy was established in 12 patients(70.5%)after lymph node,liver and omental metastases were found.Three patients exhibited biliary tree gastrinomas as well as duodenal gastrinoma(s).In two cases,the ectopic gastrinoma was removed at the same time as pancreatic surgery,while in the third case,the biliary tree gastrinoma was resected one year after DP because of recurrence of ZES.CONCLUSION:These findings suggest the importance of checking for the presence of ectopic gastrinomas in the biliary tree in MEN1 patients undergoing ZES surgery. | Francesco Tonelli Francesco Giudici Gabriella Nesi Giacomo Batignani Maria Luisa Brandi | 2013 | World Journal of Gastroenterology2013，19，45： | 3 |
| 8 | Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease显示文摘 | Marcello Tonelli Frank Sacks Malcolm Arnold Lemuel Moye Barry Davis Marc Pfeffer | 2008 | Circulation2008，，2： | 3 |
| 9 | Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.)显示文摘 | Francesca Sparvoli Cathie Martin Attilio Scienza Giuseppe Gavazzi Chiara Tonelli | 1994 | Plant Molecular Biology1994，，5： | 3 |
| 10 | 钢包和中间包内衬耐火材料与碳钢的化学反应显示文摘在有些情况下,对钢产品内部质量的影响并不取决于生产过程中的误操作,而是低估了液态钢水与不同工序中接触到的材料间的化学反应。尤其是在铸锭生产中,这一点尤为明显。讨论了钢包与中间包内衬耐材与普碳钢间发生的化学反应。这些试验涉及高铝质、铝硅质、铝镁尖晶石质耐火材料,研究了它们在液态钢水中形成夹杂物的倾向性。试验结果表明,在钢水—耐材接触面上会产生一个富含MnO的新相,这一新相的量与二氧化硅在耐材中的活性及锰在钢液里的活性成正比。试验还表明,由液态钢水与耐火材料相互反应产生的接触面可产生新的外来夹杂物进入钢液中。试验结束后,对钢样中新的夹杂物成分做的分析表明,成分取决于耐材—钢水接触面的组成。因此,不同钢厂应该结合自身生产的钢种产品化学组成来选用耐火材料的化学成分设计。 | F Cirilli A Mazzarano M Tonelli 沈钟铭(译) 职建军(校) | 2012 | 世界钢铁2012，12，4： | 3 |
| 11 | 冠状动脉疾病患者的蛋白尿、受损肾功能和不良预后:对一项先前进行的随机试验的分析 | Tonelli M. Jose P. Curhan G. 郭俊 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，0，3： | 2 |
| 12 | Yb:NGW激光晶体生长及光谱性能显示文摘采用提拉法生长了φ30mm×70mm的掺镱钨酸钆钠[Yb:NaGd(WO4)2,Yb:NGW]晶体,并对晶体进行了退火处理。讨论了Yb:NGW晶体的生长工艺。确定了最佳生长工艺参数为:提拉速率为1~2mm/h,转速为15~18r/min,冷却速率为10℃/h,轴向温度梯度为液面上0.7~1℃/mm。通过热重–差热分析(thermogravimetry–differential thermal analysis,TG–DTA),X射线衍射(X-raydiffraction,XRD)对退火的晶体进行表征。测试了晶体的红外光谱和Raman光谱,并对出现的峰值进行了振动归属。测量了晶体的吸收光谱和荧光光谱。由TG–DTA曲线得到晶体熔点为1252.02℃。XRD分析表明:晶体属于四方晶系、白钨矿结构、I41/a空间群,计算的晶胞参数a=0.53603nm,c=1.11628nm。吸收光谱显示:晶体在968nm处吸收峰最强,半峰宽为57nm,适合激光二极管泵浦。 | 林海 张莹 李春 张学建 曾繁明 MAURO Tonelli 刘景和 | 2010 | 硅酸盐学报2010，38，5： | 2 |
| 13 | Well-differentiated endocrine tumor of the distal common bile duct: a case study and literature review显示文摘 | Gabriella Nesi Antonella Lombardi Giacomo Batignani Ferdinando Ficari Carlos A. Rubio Francesco Tonelli | 2006 | Virchows Archiv2006，，1： | 2 |
| 14 | Recent advances on the regulation of anthocyanin synthesis in reproductive organs显示文摘 | Katia Petroni Chiara Tonelli | 2011 | Plant Science2011，，3： | 2 |
| 15 | Spectral properties of Tm,Ho:LiYF_4 laser crystal显示文摘The LiYF4 single crystal codoped with thulium and holmium ions was successfully grown by the Cz method. The optimal technical parameters obtained were as follows: the pulling rate was 0.16 mm/h; the rotation speed was 3 rpm; the cooling rate was 15 °C/h. The result of XRD curve showed that as-grown Tm,Ho:LiYF4 laser crystal belonged to the monoclinic system with scheelite-type structure and space group I41/a. The cell parameters calculated were: a=0.52160 nm, c=1.09841 nm and Z=4. Absorption and fluorescence spectra of Tm,Ho:LiYF4 laser crystal at room temperature were measured and analysed. The absorption cross section, FWHM and absorption coefficient at 779.3 nm calculated were 7.44×10-21 cm2, 8.7 nm and 2.23 cm-1, respectively. An intensive fluorescence emission peak appeared near 2045 nm. The emission cross section and fluorescence lifetime were 0.87×10-20 cm2 and 10.8 ms, respectively. The ratio of Tm-Ho transfer to its back-transfer process was 10.6. | 李春 张莹 张学建 曾繁明 Mauro Tonelli 刘景和 | 2011 | Journal of Rare Earths2011，29，6： | 2 |
| 16 | A Clinical Outcome-Based Prospective Study on Venous Thromboembolism After Cancer Surgery: The @RISTOS Project显示文摘 | Giancarlo Agnelli Giorgio Bolis Lorenzo Capussotti Roberto Mario Scarpa Francesco Tonelli Erminio Bonizzoni Marco Moia Fabio Parazzini Romina Rossi Francesco Sonaglia Bettina Valarani Carlo Bianchini Gualberto Gussoni | 2006 | Annals of Surgery2006，，1： | 2 |
| 17 | Is lymphatic status related to regression of inflammation in Crohn's disease?显示文摘AIM:To investigate the status of the lymphatic vessels in the small bowel affected by Crohn's disease(CD) at the moment of surgery.METHODS:During the period January 2011-June 2011,25 consecutive patients affected by CD were operated on in our Institution.During surgery,Patent Blue Ⅴ was injected subserosally and the way it spread along the subserosa of the intestinal wall,through the mesenterial layers towards the main lymphatic collectors and eventually to the lymph nodes was observed and recorded.Since some patients had been undergone strictureplasty at previous surgery,we also examined the status of intestinal lymph vessels after previous strictureplasties.The same procedure was performed in a control group of 5 patients affected by colorectal cancer.Length of lesions,caliber,maximal thickness of the diseased intestinal wall,thickness of the wall at injection site and thickness of the mesentery were evaluated at surgery.RESULTS:We observed three features after the injection of Patent Blue Ⅴ in the intestinal loops:(1) Macroscopically healthy terminal ileum of patients with CD or colon cancer showed thin lymphatic vessels linearly directed toward the mesentery;(2) In mild lesions in which the intestinal wall did not reach 8 mm of thickness,we observed short,wide and tortuous lymphatic vessels directed longitudinally along the intestinal axis toward disease-free areas and then transversally toward the mesentery;and(3) Injection in the severely affected lesions,that had a thickness of the intestinal wall over 10 mm,did not show any feature of lymphatic vessels at least on the subserosal surface.There was a correlation between the thickness of the parietal wall and the severity of the lymphatic alterations.Normal lymphatic vessels were observed at previous strictureplasties in the presence of complete regression of the inflammation.CONCLUSION:Injection of Patent Blue Ⅴ in the intestinal wall could help distinguish healthy tracts of the small bowel from those macroscopically borderline. | Francesco Tonelli Francesco Giudici Gadiel Liscia | 2012 | World Journal of Gastrointestinal Surgery2012，4，10： | 2 |
| 18 | New fluorinated thermoplastic elastomers显示文摘 | Tonelli C Trombetta T Scicchitano M | 1996 | Journal of Applied Polymer Science1996，59，2： | 1 |
| 19 | Efficient visible laser emission of GaN laser diode pumped Pr-doped fluoride crystals显示文摘 | F Cornacchia A Di Lieto M Tonelli | 2008 | Opt Express2008，16，15： | 1 |
| 20 | Release characteristics of the non-toxic insect repellant 2-undecanone from its crystalline inclusion compound with α-cyclodextrin显示文摘 | WHANG H S TONELLI A | | 0，，1： | 1 |
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