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| 1 | 肠系膜与克罗恩病关系的研究进展显示文摘近年来,肠系膜作为一个完整的组织器官备受关注,它在消化道疾病的进展中扮演了一个怎样的角色有待探究。不少研究发现肠系膜的病理效应可能在炎症性肠病发展过程中发挥了重要作用,肠系膜的一些异常改变可能促进炎症发展。克罗恩病(Crohn disease,CD)是炎症性肠病常见的一种亚型,其具体发病机制至今仍不明确,但免疫机制应是其重要的发病机制之一。肠系膜在系统解剖和病理改变上与CD关系密切,对评估CD的活动性复发以及临床诊断具有一定指导意义。结合相关研究,本文将从肠系膜的解剖、肠系膜改变、CD的活动性评估、治疗等方面作一综述。 | 何慧 蔡利军 施易辉 芮晓薇 | 2021 | 浙江医学2021，43，17： | 0 |
| 2 | Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction:An exploratory proposal based on basic and clinical data显示文摘Crohn’s disease(CD)is caused by immune,environmental,and genetic factors.It can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains unclear.Emerging biological and small-molecule drugs have advanced the treatment of CD;however,a considerable proportion of patients are non-responsive to all known drugs.To achieve a breakthrough in this field,innovations that could guide the further development of effective therapies are of utmost urgency.In this review,we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases,and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary data.The supporting evidence is fully summarized,including the existence of lymphatic system dysfunction,recognition of the inside-out model,disorders of immune cells,changes in cell plasticity,partial overlap of the underlying mechanisms,and common gut-derived fatty and bile acid metabolism.Another benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases,especially CD,as this model is good at presenting and mimicking lymphatic dysfunction.More importantly,the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD. | Yu-Wei Zhou Yue Ren Miao-Miao Lu Ling-Ling Xu Wei-Xin Cheng Meng-Meng Zhang Lin-Ping Ding Dong Chen Jian-Guo Gao Juan Du Ci-Liang Jin Chun-Xiao Chen Yun-Fei Li Tao Cheng Peng-Lei Jiang Yi-Da Yang Peng-Xu Qian Peng-Fei Xu Xi Jin | 2024 | World Journal of Gastroenterology2024，30，1： | 0 |
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