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| 1 | MicroRNA-31 expression in colorectal serrated pathway progression显示文摘MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers(CRC).We have recently observed that microRNA-31(miR-31)expression is associated with BRAF mutation and prognosis in CRC.Moreover,high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps(HPs).These results suggest that miR-31 may contribute to the progression of serrated lesions.At a follow-up colonoscopy,we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features.Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component.Higher miR-31 expression was observed in the carcinoma component(57-fold increase)and the HP component(8-fold increase)compared with the paired normal mucosa,suggesting that miR-31 may be one of the key molecules in serrated pathway progression. | Hironori Aoki Katsuhiko Nosho Hisayoshi Igarashi Miki Ito Kei Mitsuhashi Takafumi Naito Eiichiro Yamamoto Tokuma Tanuma Masafumi Nomura Hiroyuki Maguchi Toshiya Shinohara Hiromu Suzuki Hiroyuki Yamamoto Yasuhisa Shinomura | 2014 | World Journal of Gastroenterology2014，20，34： | 5 |
| 2 | Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)显示文摘 | Hiroaki Takahashi Yoshiaki Arimura Hosokawa Masao Satoshi Okahara Tokuma Tanuma Junichi Kodaira Hidetoshi Kagaya Yuichi Shimizu Kaku Hokari Hiroyuki Tsukagoshi Yasuhisa Shinomura Masahiro Fujita | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 3 | Sexdifferences in the metabolism and excretion of nilva-dipine, a new dihydropyridine calcium antagonist,in rats 显示文摘 | Terashita S Tokuma Y Sekiguchi M | 1989 | Xenobiotica1989，19，11： | 1 |
| 4 | Stereose-lective oxidation of nilvadipine,a new dihydropyri-dine calcium antagonist,in rat and dog liver 显示文摘 | Niwa T Tokuma Y Nakagawa K | 1989 | Drug Metab Dispos1989，17，1： | 1 |
| 5 | Stereoselective pharmacoki- netics of dihydropyridine calcium antagonists 显示文摘 | Tokuma Y Noguchi H | 1995 | J Chromatogr A1995，694，1： | 1 |
| 6 | Structure of ente- rocin:X-ray Analysis of m-Bromobenzoyl enterocin dihydrate 显示文摘 | TOKUMA Y MIYAIRI N MORIMOTO Y | 1976 | The Journal of Antibiotics1976，29，： | 1 |
| 7 | Stereoselective pharmacokinetics of dihydropyridine calcium antagonists显示文摘 | TOKUMA Y NOGUCHI H | 1995 | J Chromatogr:A1995，694，1： | 1 |
| 8 | Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)显示文摘 | Hiroaki Takahashi Yoshiaki Arimura Hosokawa Masao Satoshi Okahara Tokuma Tanuma Junichi Kodaira Hidetoshi Kagaya Yuichi Shimizu Kaku Hokari Hiroyuki Tsukagoshi Yasuhisa Shinomura Masahiro Fujita | 2010 | Gastrointestinal Endoscopy2010，，2： | 1 |
| 9 | Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)显示文摘 | Hiroaki Takahashi Yoshiaki Arimura Hosokawa Masao Satoshi Okahara Tokuma Tanuma Junichi Kodaira Hidetoshi Kagaya Yuichi Shimizu Kaku Hokari Hiroyuki Tsukagoshi Yasuhisa Shinomura Masahiro Fujita | 2010 | Gastrointestinal Endoscopy2010，，2： | 1 |
| 10 | Structure of entero-cin; X-ray analysis of m-Bromobenzoyl enterocin dihydrate显示文摘 | Tokuma Y Miyairi N Morimoto Y | 1976 | J Antibiot1976，29，10： | 1 |
| 11 | Enantioselective synthesis of 4-substituted γ-lactones显示文摘 | Tokuma M Kitamura R Noyori | 1990 | Tetrahedron Let1990，31，38： | 1 |
| 12 | Self- assembling properties of glycolipid biosurfactants and their potential applications显示文摘 | Dai Kitamoto Tomotake Morita Tokuma Fukuoka | 2009 | Current Opinion in Colloid & Interface Science2009，14，： | 1 |
| 13 | Stereoselective pharmacokinetics of dihydropyridine calcium antagonists 显示文摘 | TOKUMA Y NOGUCHI H | 1995 | J Chromatogr A1995，694，1： | 1 |
| 14 | Present situation and development trends of desulfurization technology显示文摘 | Tokuma Arai at al | 1991 | MHI Ltd technical review1991，28，1： | 1 |
| 15 | Comparative pharmacokinetic/pharmacodynamic analysis of proton pump inhibitors omeprazole, lansoprazole and pantoprazole, in humans显示文摘 | Katashima M Yamamoto K Tokuma Y | 1998 | Eur J Drug Metab Pharmcokinet1998，23，1： | 1 |
| 16 | Processed blood volume impacts clinical efficacy in patients with ulcerative colitis undergoing adsorptive depletion of myeloid lineage leucocytes显示文摘 | Naoki Yoshimura Tokuma Tadami Takaaki Kawaguchi Minako Sako Hiroshi Yoshimoto Toshihiko Yamaka Masakazu Takazoe | 2012 | Journal of Gastroenterology2012，，1： | 1 |
| 17 | Optimal structure design methodology for compound multiaxis machine tools I & II 显示文摘 | NAKAMINAMI M TOKUMA T MATSUMOTO K | 2007 | Int J of Automation Technology2007，1，2： | 1 |
| 18 | Disruption of the Membrane-Bound Alcohol Dehydrogenase-Encoding Gene Improved Glycerol Use and Dihydroxyacetone Productivity in Gluconobacter oxydans显示文摘 | Hiroshi HABE Tokuma FUKUOKA Tomotake MORITA Dai KITAMOTO Toshiharu YAKUSHI Kazunobu MATSUSHITA Keiji SAKAKI | 2010 | Bioscience, Biotechnology, and Biochemistry2010，，7： | 1 |
| 19 | Optimal structure design methodology for compound multiaxis machine tools-III 显示文摘 | NAKAMINAMI M TOKUMA T MATSUMOTO K | 2008 | Int J of Automation Tech- nology2008，2，1： | 1 |
| 20 | Structural characterization and surface - active properties of a new glycolipid biosurfactant, mono - acylated mannosylerythritol lipid, produced from glucose by Pseudozyma antarctica 显示文摘 | FUKUOKA TOKUMA MORITA TOMOTAKE KONISHI MASAAKI | 2007 | Applied Microbiology and Biotechnology2007，76，4： | 1 |
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