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| 1 | Downstaging disease in patients with hepatocellular carcinoma outside up-to-seven criteria: Strategies using degradable starch microspheres transcatheter arterial chemo-embolization显示文摘AIM: To evaluate the downstaging rates in hepatitis C virus-patients with hepatocellular carcinoma(HCC), treated with degradable starch microspheres transcatheter arterial chemoembolization(DSM-TACE), to reach new-Milan-criteria(nM C) for transplantation. METHODS: This study was approved by the Ethics Committee of our institution. From September 2013 to March 2014 eight patients(5 men and 3 women) with liver cirrhosis and multinodular HCC, that did not meet n MC at baseline, were enrolled in this study. Patients who received any other type of treatment such as termal ablation or percutaneous ethanol injection were excluded. DSM-TACE was performed in all patients using Embo Cept? S and doxorubicin. Baseline and follow-up computed tomography or magnetic resonance imaging was assessed measuring the longest enhancing axial dimension of each tumor according to the modified Response Evaluation Criteria In Solid Tumors measure-ments, and medical records were reviewed.RESULTS: DSM-TACE was successfully performed in all patients without major complication. We treated 35 lesions(mean 4.3 per patient). Six of eight patients(75%) had their HCC downstaged to meet nM C. Every patient whose disease was downstaged eventually underwent transplantation. The six patients who received transplant were still living at the time of this writing, without recurrence of HCC. Baseline age(P = 0.25), Model for End-stage Liver Disease score(P = 0. 77), and α-fetoprotein level(P = 1.00) were similar between patients with and without downstaged HCC. CONCLUSION: DSM-TACE represents a safely and effective treatment option with similar safety and efficacy of conventional chemoembolization and could be successfully performed also for downstaging disease in patients without n MC, allowing them to reach liver transplantation. | Antonio Orlacchio Fabrizio Chegai Stefano Merolla Simona Francioso Costantino Del Giudice Mario Angelico Giuseppe Tisone Giovanni Simonetti | 2015 | World Journal of Hepatology2015，7，12： | 23 |
| 2 | Moving forward in the treatment of cholangiocarcinoma显示文摘Despite being the second most frequent primary liver tumor in humans,early diagnosis and treatment of cholangiocarcinoma(CCA)are still unsatisfactory.In fact,survival after 5 years is expected in less than one fourth of patients diagnosed with this disease.Rare incidence,late appearance of symptoms and heterogeneous biology are all factors contributing to our limited knowledge of this cancer and determining its poor prognosis in the clinical setting.Several efforts have been made in the last decades in order to achieve an improved classification/understanding with regard to the diverse CCA forms.Location within the biliary tree has helped to distinguish between intrahepatic,perihilar and distal CCA types.Sequence analysis contributed to identifying several characteristic genetic aberrations in CCA that may also serve as possible targets for therapy.Novel findings are expected to significantly improve the management of this malignancy in the near future.In this changing scenario our review focuses on the current and future strategies for CCA treatment.Both systemic and surgical treatments are discussed in detail.The results of the main studies in this field are reported,together with the ongoing trials.The current findings suggest that an integrated multidisciplinary approach to this malignancy would be helpful to improve its outcome. | Tommaso M Manzia Alessandro Parente Ilaria Lenci Bruno Sensi Martina Milana Carlo Gazia Alessandro Signorello Roberta Angelico Giuseppe Grassi Giuseppe Tisone Leonardo Baiocchi | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 6 |
| 3 | 基于实物的博物馆里的家庭学习——共同注意的作用显示文摘共同注意是从小开始亲子沟通的一个基础。此项研究透过54个家庭在自然历史博物馆里对实景模型馆的探索体验,探讨了加强共同注意将会如何引起学习的强化。本文作者使用2×2的析因设计,检验了两种旨在增进父母跟孩子(5-8岁)对实景模型里的实物的共同注意的干预措施。在一种干预里,家庭使用手电筒去探索昏暗的实景模型,由此限制其视野;在另一种干预里,研究者给家庭提供引导标示提示,使其将注意力集中在特定的实景模型的特征上。结果显示,相较于控制器,用手电筒去探究实景模型馆的家庭明显更可能形成共同注意;而且,这些家庭一旦建立对某物的共同注意,他们就更可能参与到对此物的学习谈论中,由此表明在基于实物的学习环境里,比如在自然历史博物馆,相对简单地操作共同注意是一种支持家庭学习的有效手段。 | Kaleen Tison Povis Kevin Crowley 张莉 | 2016 | 中国博物馆2016，，2： | 4 |
| 4 | De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature显示文摘BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.RESULTS Emerging evidence suggests that the liver is an immunologically privileged organ able to support immunosuppression discontinuation in carefully selected recipients. Malignancies are often detected in liver transplant patients undergoing daily immunosuppression regimens. Post-transplant lymphoproliferative diseases and skin tumors are the most detected de novo malignancies in the pediatric and adult OLT population, respectively. To date, immunosuppression withdrawal has been achieved in up to 40% and 60% of well-selected adult and pediatric recipients, respectively. In both populations, a clear benefit of immunosuppression weaning protocols on de novo malignancies is difficult to ascertain because data have not been specified in most of the clinical experiences. CONCLUSION The selected populations of tolerant pediatric and adult liver transplant recipients greatly benefit from immunosuppression weaning. There is still no strong clinical evidence on the usefulness of immunosuppression withdrawal in OLT recipients on malignancies. An interesting focus is represented by the complete reconstitution of the immunological pathways that could help in decreasing the incidence of de novo malignancies and may also help in treating liver transplant patients suffering from cancer. | Tommaso Maria Manzia Roberta Angelico Carlo Gazia Ilaria Lenci Martina Milana Oludamilola T Ademoyero Domiziana Pedini Luca Toti Marco Spada Giuseppe Tisone Leonardo Baiocchi | 2019 | World Journal of Gastroenterology2019，25，35： | 3 |
| 5 | Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients显示文摘 | Martínez-Llordella Marc Lozano Juan José Puig-Pey Isabel Orlando Giuseppe Tisone Giuseppe Lerut Jan Benítez Carlos Pons Jose Antonio Parrilla Pascual Ramírez Pablo Bruguera Miquel Rimola Antoni Sánchez-Fueyo Alberto | 2008 | Journal of Clinical Investigation2008，，8： | 3 |
| 6 | Impact of immunosuppression minimization and withdrawal in long-term hepatitis C virus liver transplant recipients显示文摘AIM:To investigate the effects of different immunosuppressive regimens and avoidance on fibrosis progression in hepatitis C virus(HCV)liver transplant(LT)recipients.METHODS:We retrospectively compared the liver biopsies of well-matched HCV LT recipients under calcineurin inhibitors(CNI group,n=21)and mycophenolate(MMF group,n=15)monotherapy,with those patients who successfully withdrawn immunosuppression(IS)therapy from at least 3 years(TOL group,n=10).To perform the well-matched analysis,all HCV transplanted patients from December 1993 were screened.Only those HCV patients who reached the following criteria were considered for the analysis:(1)at least3 years of post-operative follow-up;(2)patients with normal liver graft function under low dose CNI monotherapy(CNI group);(3)patients with normal liver graft function under antimetabolite(Micophenolate Mofetil or coated mycophenolate sodium)monotherapy(MMF group);and(4)recipients with normal liver function without any IS.We excluded from the analysis recipients who were IS free or under monotherapy for<36 mo,recipients with cirrhosis or with unstable liver function tests.RESULTS:Thirty six recipients were enrolled in the study.Demographics,clinical data,time after LT and baseline liver biopsies were comparable in the three groups.After six years of follow-up,there was no worsening of hepatic fibrosis in the MMF group(2.5±1.5Ishak Units vs 2.9±1.7 Ishak Units,P=0.5)and TOL group(2.7±10.7 vs 2.5±1.2,P=0.2).In contrast,a significant increase in the fibrosis score was observed in the CNI group(2.2±1.7 vs 3.9±1.6,P=0.008).The yearly fibrosis progression rate was significantly worse in the CNI group(0.32±0.35)vs MMF group(0.03±0.31,P=0.03),and TOL group(-0.02±0.27,P=0.02).No differences have been reported in grading scores for CNI group(2.79±1.9,P=0.7),MMF group(3.2±1.5,P=0.9)and TOL group(3.1±1.4,P=0.2).Twenty four patients were treated with low dose ribavirin(8TOL,7 MMF,9 CNI).The hepatitis C titers were comparable in the three groups.No episodes of rejection have been reported despite differences of liver function test in the three groups during the observational period.CONCLUSION:IS withdrawal and MMF monotherapy is safe and seems to be associated with the slowest fibrosis progression in HCV LT recipients. | Tommaso Maria Manzia Roberta Angelico Paolo Ciano Jon Mugweru Kofi Owusu Daniele Sforza Luca Toti Giuseppe Tisone | 2014 | World Journal of Gastroenterology2014，20，34： | 3 |
| 7 | Granulo-monocyto apheresis is more effective in mild ulcerative colitis than in moderate to severe disease显示文摘AIM:To evaluate whether the effectiveness of Granulomonocyto apheresis(GMA),a technique that consists of the extracorporeal removal of granulocytes and monocytes from the peripheral blood,might vary according to the severity of ulcerative colitis(UC)in patients with mild to moderate-severe disease UC activity.METHODS:We retrospectively reviewed prospectively collected data of patients undergoing GMA at our inflammatory bowel disease centre who had at least a 6 mo of follow-up.The demographics,clinical and laboratory data were extracted from the patients’charts and electronic records.The severity of UC was scored according to the Modified Truelove Witts Severity Index(MTWSI).A clinical response was defined as a decrease from baseline of≥2 points or a value of MTWSI≤2 points.RESULTS:A total of 41(24 males/17 females;meanage 47 years)patients were included in the study.After GMA cycle completion,21/28(75%)of mild UC patients showed a clinical response compared with 7/13(54%)of patients with moderate to severe disease(P=0.27).At 6-mo,14/28(50%)of the mild UC patients maintained a clinical response compared with 2/13(15%)of the patients with moderate to severe disease(P=0.04).After the GMA cycle completion and during the 6-mo follow up period,13/16(81%)and 9/16(56%)of mild UC patients with intolerance,resistance and contraindications to immunosuppressants and/or biologics showed a clinical response compared with 2/6(33%)and 0/6(0%)of patients with moderate to severe disease activity with these characteristics(P=0.05and P=0.04,respectively).CONCLUSION:Patients with mild UC benefit from GMA more than patients with moderate to severe disease in the short-term period.GMA should be considered a valid therapeutic option in cases of contraindications to immunosuppressants,corticosteroids and/or biologics. | Chiara De Cassan Edoardo Savarino Piero Marson Tiziana Tison Giorgia Hatem Giacomo Carlo Sturniolo Renata D'Incà | 2014 | World Journal of Gastroenterology2014，20，45： | 2 |
| 8 | Chronic rejection after liver transplantation:Opening the Pandora’s box显示文摘Chronic rejection(CR)of liver allografts causes damage to intrahepatic vessels and bile ducts and may lead to graft failure after liver transplantation.Although its prevalence has declined steadily with the introduction of potent immunosuppressive therapy,CR still represents an important cause of graft injury,which might be irreversible,leading to graft loss requiring re-transplantation.To date,we still do not fully appreciate the mechanisms underlying this process.In addition to T cell-mediated CR,which was initially the only recognized type of CR,recently a new form of liver allograft CR,antibody-mediated CR,has been identified.This has indeed opened an era of thriving research and renewed interest in the field.Liver biopsy is needed for a definitive diagnosis of CR,but current research is aiming to identify new non-invasive tools for predicting patients at risk for CR after liver transplantation.Moreover,the minimization or withdrawal of immunosuppressive therapy might influence the establishment of subclinical CR-related injury,which should not be disregarded.Therapies for CR may only be effective in the“early”phases,and a tailored management of the immunosuppression regimen is essential for preventing irreversible liver damage.Herein,we provide an overview of the current knowledge and research on CR,focusing on early detection,identification of non-invasive biomarkers,immunosuppressive management,re-transplantation and future perspectives of CR. | Roberta Angelico Bruno Sensi Tommaso M Manzia Giuseppe Tisone Giuseppe Grassi Alessandro Signorello Martina Milana Ilaria Lenci Leonardo Baiocchi | 2021 | World Journal of Gastroenterology2021，27，45： | 2 |
| 9 | Experimental data and theoretical model ing of gas flows through metal capillary leaks 显示文摘 | Tison S A | 1993 | Vacuum1993，44，： | 2 |
| 10 | The Tor Vergata weaning off immunosuppression protocol in stable HCV liver transplant patients: The updated follow up at 78 months显示文摘 | Giuseppe Orlando Tommaso Manzia Leonardo Baiocchi Alberto Sanchez-Fueyo Mario Angelico Giuseppe Tisone | 2008 | Transplant Immunology2008，，1： | 2 |
| 11 | Feature Fusion to Improve Road Network Extraction in High Resolution SAR Images 显示文摘 | Lisini G Tison C Tupin F | 2006 | IEEE Geoscience and Remote Sensing Letters2006，3，2： | 1 |
| 12 | Quality of life and long - term follow- up after kidney transplantation: A 30 - year clinical study 显示文摘 | Pisani F Vennarecci G Tisone G | 1997 | Transplantation Proceedings1997，29，： | 1 |
| 13 | Acquired hepatoeerebral degeneration 显示文摘 | Meissner W Tison F | 2011 | Handb Clin Neurol2011，100，： | 1 |
| 14 | Vibrio aestuarianus: a new species from estuarine waters and shellfish显示文摘 | Tison DL Seidler RJ | 1983 | International Journal of Systematic and Evolutionary Microbiology1983，33，： | 1 |
| 15 | Low-dose hepatitis B immunoglobulin given 'on demand' in combination with lamivudine:a highly cost-effective approach to prenent recurrent hepatitis B virus infection in the long-term follow-up after liver transplantation显示文摘 | Paolo DD Tisone G Piccolo P | 2004 | Transplantation2004，77，8： | 1 |
| 16 | Fuzzy Behavior of Mechanical Systems with Uncertain Boundary Condi- tions 显示文摘 | Cherki A Plessis G Lallemand B Tison T Level P | 2000 | Computer Methods in Applied Mechanics and Engineering2000，189，： | 1 |
| 17 | Clinical drug monitoring by microdialysis:application to levodopa therapy in Parkinson's disease显示文摘 | O'Connell Mr Tison F Quinn NP | 1996 | Br J Clin Phannacol1996，42，6： | 1 |
| 18 | Effects of mycophenolate mofetil introduction in liver transplant patients: results from an observational, non‐interventional, multicenter study ( LOBSTER )显示文摘 | Hans J. Schlitt Sven Jonas Tom M. Ganten Gerrit Grannas Christian Moench Falk Rauchfuss Aiman Obed Giuseppe Tisone Antonio D. Pinna Giorgio E. Gerunda Susanne Beckebaum | 2013 | Clin Transplant2013，，3： | 1 |
| 19 | Growth of Legionella pneumophila in association with blue-green algae (Cyanobacteria)显示文摘 | Tison DL Pope DH Cherry WB | 1980 | Appl Environ Microbiol1980，39，： | 1 |
| 20 | 低压电气装置的电能效率(英文)显示文摘从定义上而言,能效可以分为两种类型:旨在减少能源消耗的被动能效(passive energy efficiency)和旨在控制能源消耗的主动能效(active energy efficiency)。给出在低压电气装置中实现主动能效所采用的迭代过程的基本特性。根据迭代过程的结果,可以对低压电气装置的配置概况进行定义,给出已经做了什么、还可以做些什么的整体概述。从而可以在能效方面实现对低压电气装置进行分类。IEC60364提供了支持此理念的最佳国际标准化平台。 | Etienne TISON | 2011 | 建筑电气2011，30，10： | 1 |
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