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| 1 | Current approaches to reduce or eliminate mitochondrial DNA mutations显示文摘Mitochondrial DNA(mt DNA)mutations have been implicated in a broad range of disorders which severely affect human health(Wallace,1999).Some drugs have been developed to slow down pathological changes of mitochondrial disorders.However,there is no effective treatment for patients with mt DNA mutations.mt DNA is less protected and has fewer repair mechanisms than nuclear DNA(n DNA).Such a reality results in a much higher | Liang Yang Tingfang Mei Xiaobing Lin Haite Tang Yi Wu Rui Wang Jinglei Liu Zahir Shah Xingguo Liu | 2016 | Science China(Life Sciences)2016，59，5： | 3 |
| 2 | Retrieval study of 1-dropsonde's motion显示文摘 | Fand Hanxian Huang Sixun Wang Tingfang | 2004 | Journal of Hydrodynamics:Ser A2004，19，1： | 1 |
| 3 | Synthesis of New Catalytic Material Molybdenum Nitride in Mixture of Nitrogen and Hydrogen显示文摘 | XIE Guohuang BAI Tingfang AN Lidun WANG Hanqin 1) (Lanzhou Institute of Chemical physics The Chinese Academy of Sciences Lanzhou 730000) YOU Jinmao (Department of Chemistry Qufu Normal University Qufu 273165) Keywords Synthesis Mo | 1997 | 分子催化1997，，02： | 1 |
| 4 | Study on the distribution of non-point source pollution in the watershed of Miyun reservoir, Beijing, China 显示文摘 | Wang Xiaoyan Li Tingfang Xu Qian | 2001 | Water Science and Technology2001，44，7： | 1 |
| 5 | Study of MO2N catalyst activity and stability in CO oxidation显示文摘 | Guohuang Xie Tingfang Bai Lidun An Hanqing Wang Jinmao You | 1998 | Reaction Kinetics and Catalysis Letters1998，，2： | 1 |
| 6 | Study on the distribution of non-point source pollution in the watershed of Miyun reservoir, Beijing, China 显示文摘 | Wang Xiaoyan Li Tingfang Xu Qian | 2001 | Water Science and Technology2001，44，7： | 1 |
| 7 | CD39 is an ecto-(Ca2+,Mg2+)-apyrase显示文摘 | Wang Tingfang Guidotti G | 1996 | J Biolog Chem1996，271，17： | 1 |
| 8 | GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice显示文摘GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. Here we investigated the role of GPR54 in T cell and immune tolerance. GPR54 deficiency led to an enlarged thymus, an increased number of thymocytes, and altered thymic micro-architecture starting around puberty, indicating GPR54 function in T-cell development through its regulatory effect on the gonadal system. However, flow cytometry revealed a significant reduction in the peripheral regulatory T cell population and a moderate decrease in CD4 single-positive thymocytes in prepubertal Gpr54^(-/-) mice. These phenotypes were confirmed in chimeric mice with GPR54 deficient bone marrow-derived cells. In addition, we found elevated T cell activation in peripheral and thymic T cells in Gpr54^(-/-) mice. When intact mice were immunized with myelin oligodendrocyte glycoprotein, a more severe experimental autoimmune encephalomyelitis(EAE) developed in the Gpr54^(-/-) mice. Interestingly, aggravated EAE disease was also manifested in castrated and bone marrow chimeric Gpr54^(-/-) mice compared to the respective wild-type control,suggesting a defect in self-tolerance resulting from GPR54 deletion through a mechanism that bypassed sex hormones. These findings demonstrate a novel role for GPR54 in regulating self-tolerant immunity in a sex hormone independent manner. | Roumei Xing Fang Liu Yiqing Yang Xueqin Cui Tongtong Wang Ling Xie Yongliang Zhao Lei Fang Tingfang Yi Biao Zheng Mingyao Liu Huaqing Chen | 2018 | Science China(Life Sciences)2018，61，6： | 1 |
| 9 | Influence of shaped and modified Hβ zeolite on etherification of FCC light gasoline 显示文摘 | Hu Tingfang Chen Jinpeng Wang Haiyan | 2006 | Microporous Mesoporous Materials2006，94，123： | 1 |
| 10 | Influence of shaping condition on etherification performanceof Hβ zeolite 显示文摘 | Hu Tingfang Chen Jinpeng Wang Haiyan | 2006 | Petroleum Science and Technology2006，24，12： | 1 |
| 11 | Advanced nano drug delivery systems for neuroprotection against ischemic stroke显示文摘Ischemic stroke(IS)represents a significant threat to brain health due to its elevated mortality and disability rates.The efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier(BBB)and limited bioavailability.Conversely,advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug concentrations.This review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of IS.By examining these systems,researchers and clinicians can gain valuable insights and innovative concepts,illuminating the potential of advanced neuroprotective nano drug delivery systems.Leveraging these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS. | Chenchen Xie Jun Liao Ning Zhang Yuhan Sun Yi Li Liyan Xiong Yingnan Zhang Xiaoyan Liu Wei Su Heming Chen Ping Zeng Xiaoqing Zhang Ying Lu Tingfang Wang Chuan Zhang | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 12 | PRIMPOL competes with RAD51 to resolve G-quadruplexinduced replication stress via its interaction with RPA显示文摘PRIMPOL(primase-polymerase)is a recently discovered DNA primase-polymerase involved in DNA damage tolerance and replication stress response in eukaryotic cells.However,the detailed mechanism of the PRIMPOL response to replication stress remains elusive.Here,we demonstrate that replication-related factors,including replication protein A(RPA),regulate the accumulation of PRIMPOL in subnuclear foci in response to replication stress induced by replication inhibitors.Moreover,PRIMPOL works at G-quadruplexes(G4s)in human cells to resolve the replication stress induced by G4s.The formation of PRIMPOL foci persists throughout the cell cycle.We further demonstrate that PRIMPOL competes with RAD51 to resolve G4-induced replication stress.In conclusion,our results provide novel insight into the mechanism of PRIMPOL in G4s to resolve replication stress and competition between PRIMPOL(repriming)-and RAD51(fork reversal)-mediated pathways,which indicates a new strategy to improve the tumor response to DNA-damaging chemotherapy by targeting the PRIMPOL pathway. | Tingfang Li Lu Tang Haomeng Kou Feng Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 13 | Mechanism Analysis of ' 7·21' Extremely Heavy Rainstorm Process in 2012 in Beijing显示文摘Extremely heavy rainstorm occurred in Beijing on July 21,2012,which was the most serious since 1961.Based on analyzing the precipitation characteristics,formation mechanism of the rainstorm process was analyzed.Results showed that when the precipitation process occurred,it was stable east-high and west-low situation at 500 hPa,and there was a steady stream of water vapor transportation at middle and low layers and strong vertical ascending motion at 700 hPa.The distribution of physical quantity field(relative humidity,vorticity and divergence)showed that they were all benefited to the formation of rainstorm.Then,falling zone of rainstorm and the movement of rain belt,generation,development and weakening of precipitation were analyzed.Finally,according to circulation situation and the distribution of physical quantity at each layer,vertical distribution of physical quantity and distribution of water vapor and jet stream, '7·21' rainstorm model was summarized. | Mao Weiping Yan Yan Wang Tingfang Zhang Youshu | 2015 | Meteorological and Environmental Research2015，6，1： | 0 |
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