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| 1 | Study on the distribution of non-point source pollution in the watershed of Miyun reservoir, Beijing, China 显示文摘 | Wang Xiaoyan Li Tingfang Xu Qian | 2001 | Water Science and Technology2001，44，7： | 1 |
| 2 | Study on the distribution of non-point source pollution in the watershed of Miyun reservoir, Beijing, China 显示文摘 | Wang Xiaoyan Li Tingfang Xu Qian | 2001 | Water Science and Technology2001，44，7： | 1 |
| 3 | Relative efficiency and productivi- ty: a preliminary exploration of public hospitals in Beijing, China显示文摘 | Li Hao Dong Siping Liu Tingfang | 2014 | BMC Health Services Research2014，14，1： | 1 |
| 4 | Advanced nano drug delivery systems for neuroprotection against ischemic stroke显示文摘Ischemic stroke(IS)represents a significant threat to brain health due to its elevated mortality and disability rates.The efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier(BBB)and limited bioavailability.Conversely,advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug concentrations.This review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of IS.By examining these systems,researchers and clinicians can gain valuable insights and innovative concepts,illuminating the potential of advanced neuroprotective nano drug delivery systems.Leveraging these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS. | Chenchen Xie Jun Liao Ning Zhang Yuhan Sun Yi Li Liyan Xiong Yingnan Zhang Xiaoyan Liu Wei Su Heming Chen Ping Zeng Xiaoqing Zhang Ying Lu Tingfang Wang Chuan Zhang | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 5 | PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis显示文摘Glaucoma is the leading cause of irreversible blindness worldwide.In the pathogen-esis of glaucoma,activated microglia can lead to retinal ganglion cells(RGCs)apoptosis and death,however,the molecular mechanisms remain largely unknown.We demonstrate that phospholipid scramblase 1(PLSCR1)is a key regulator promoting RGCs apoptosis and their clearance by microglia.As evidenced in retinal progenitor cells and RGCs of the acute ocular hypertension(AOH)mouse model,overexpressed PLSCR1 induced its translocation from the nucleus to the cytoplasm and cytomembrane,as well as elevated phosphatidylserine exposure and reactive oxygen species generation with subsequent RGCs apoptosis and death.These damages were effectively attenuated by PLSCR1 inhibition.In the AOH model,PLSCR1 led to an increase in M1 type microglia activation and retinal neuroinflammation.Upregulation of PLSCR1 resulted in strongly elevated phagocytosis of apoptotic RGCs by activated microglia.Taken together,our study provides important insights linking activated microglia to RGCs death in the glaucoma pathogenesis and other RGC-related neurodegenerative diseases. | Jingyi Luo Qing Lian Deliang Zhu Minglei Zhao Tingfang Mei Bizhi Shang Zeqiu Yang Chujun Liu Wenchang Xu Lan Zhou Keling Wu Xinqi Liu Yuhua Lai Fuxiang Mao Weihua Li Chengguo Zuo Kang Zhang Mingkai Lin Yehong Zhuo Yizhi Liu Lin Lu Ling Zhao | 2023 | Genes & Diseases2023，10，4： | 0 |
| 6 | PRIMPOL competes with RAD51 to resolve G-quadruplexinduced replication stress via its interaction with RPA显示文摘PRIMPOL(primase-polymerase)is a recently discovered DNA primase-polymerase involved in DNA damage tolerance and replication stress response in eukaryotic cells.However,the detailed mechanism of the PRIMPOL response to replication stress remains elusive.Here,we demonstrate that replication-related factors,including replication protein A(RPA),regulate the accumulation of PRIMPOL in subnuclear foci in response to replication stress induced by replication inhibitors.Moreover,PRIMPOL works at G-quadruplexes(G4s)in human cells to resolve the replication stress induced by G4s.The formation of PRIMPOL foci persists throughout the cell cycle.We further demonstrate that PRIMPOL competes with RAD51 to resolve G4-induced replication stress.In conclusion,our results provide novel insight into the mechanism of PRIMPOL in G4s to resolve replication stress and competition between PRIMPOL(repriming)-and RAD51(fork reversal)-mediated pathways,which indicates a new strategy to improve the tumor response to DNA-damaging chemotherapy by targeting the PRIMPOL pathway. | Tingfang Li Lu Tang Haomeng Kou Feng Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 7 | Analysis of electrochemical performance of lithium carbon fluorides primary batteries after storage显示文摘Lithium carbon fluorides(Li/CFx)primary batteries are of highly interests due to their high specific energy and power densities.The shelf life is one of the major concerns when they are used as backup power,emergency power and storage power in landers,manned spacecraft or military applications.In this work,real-time storage tests are carried out for both energy-type and power-type Li/CFx pouch batteries at 25℃.Accelerated storage tests are performed at elevated temperature of 55℃.The electrochemical tests are conducted throughout the aging period of 0-365 days for various batteries to study the effects of temperature on both type of batteries.The observed electrochemical behaviors are explained with the evidences from multiple characterizations for post-tested samples. | Wen Liu Tingfang Yan Rui Guo Guoju Dang Yong Li Haijuan Pei Qibin Yan Jingying Xie | 2021 | Journal of Materiomics2021，7，6： | 0 |
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