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| 1 | Burden of celiac disease in the Mediterranean area显示文摘AIM: To estimate the burden of undiagnosed celiac disease (CD) in the Mediterranean area in terms of morbidity, mortality and health cost. METHODS: For statistics regarding the population of each country in the Mediterranean area, we accessed authoritative international sources (World Bank, World Health Organization and United Nations). The prevalence of CD was obtained for most countries from published reports. An overall prevalence rate of 1% cases/total population was finally estimated to represent the frequency of the disease in the area, since none of the available conf idence intervals of the reported rates significantly excluded this rate. The distribution of symptoms and complications was obtained from reliable reports in the same cohort. A standardized mortality rate of 1.8 was obtained from recent reports. Crude health cost was estimated for the years between symptoms and diagnosis for adults and children, and was standardized for purchasing power parity to account for the different economic prof iles amongst Mediterranean countries. RESULTS: In the next 10 years, the Mediterranean area will have about half a billion inhabitants, of which 120 million will be children. The projected number of CD diagnoses in 2020 is 5 million cases (1 million celiac children), with a relative increase of 11% compared to 2010. Based on the 2010 rate, there will be about 550 000 symptomatic adults and about 240 000 sick children: 85% of the symptomatic patients will suffer from gastrointestinal complaints, 40% are likely to have anemia, 30% will likely have osteopenia, 20% of children will have short stature, and 10% will have abnormal liver enzymes. The estimated standardized medical costs for symptomatic celiac patients during the delay between symptom onset and diagnosis (mean 6 years for adults, 2 years for children) will be about €4 billion (€387 million for children) over the next 10 years. A delay in diagnosis is expected to increase mortality: about 600 000 celiac patients will die in the next 10 years, with an excess of 44.4% vs age-and sexmatched controls. CONCLUSION: In the near future, the burden of CD will increase tremendously. Few Mediterranean countries are able to face this expanding epidemic alone. | Luigi Greco Laura Timpone Abdelhak Abkari Mona Abu-Zekry Thomas Attard Faouzi Bouguerrà Paskal Cullufi Aydan Kansu Dusanka Micetic-Turk Zrinjka Miak Eleftheria Roma Raanan Shamir Selma Terzic | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 2 | Occupational transmission of Acinetobacter baumannii from a United States serviceman wounded in Iraq to a health care worker显示文摘 | Whitman T J Qasba S S Timpone J G | 2008 | Clin Infect Dis2008，47，4： | 1 |
| 3 | A commonvariant in the FTO gene is associated with body mass indexand predisposes to childhood and adult obesity 显示文摘 | Frayling TM Timpon NJ Weedon MN | 2007 | Science2007，316，5826： | 1 |
| 4 | An analytical model of dissipated viscous and hysteretic energy due to interaction forces in a pneumatic tire: Theory and experiments显示文摘 | Brancati R Strano S Timpone F | 2011 | Mechanical Systems and Signal Processing2011，25，7： | 1 |
| 5 | Six-month incidence of bloodstream infections in intestinal transplant patients显示文摘 | Akhter K Timpone J Matsumoto C | 2012 | Transpl Infect Dis2012，14，： | 1 |
| 6 | Production of dietary fiber from the edible component of citrus fruits 显示文摘 | TIMPONE R D AVELLA M | 2002 | Fruit Proc2002，12，10： | 1 |
| 7 | Production of dietary fiber from the edible component of citrus fruits 显示文摘 | Timpon - R DAvella M | 2002 | Fruit - Processing2002，12，10： | 1 |
| 8 | An analytical model of dissipated viscous and hysteretic energy due to interaction forces in a pneumatic tire: Theory and experiments显示文摘 | Brancati R Strano S Timpone F | 2011 | Mechanical Systems and Signal Processing2011，25，7： | 1 |
| 9 | A membrane-based process for the clarification and the concentration of the cactus pear juice显示文摘 | Cassano A Conidi C Timpone R | 2007 | Journal of Food Engineering2007，80，3： | 1 |
| 10 | BK Polyomavirus Infection in the Renal Transplant Recipient显示文摘 | Gayle P. Balba Basit Javaid Joseph G. Timpone | 2013 | Infectious Disease Clinics of North America2013，，2： | 1 |
| 11 | HIV-associated intracranial aneurysmal vasculopathy in adults显示文摘 | Goldstein DA Timpone J Cupps TR | 2010 | J Rheumatol2010，37，2： | 1 |
| 12 | A membrane-based process for the clarification and the concentration of the cactus pear juice显示文摘 | CASSANO A CONIDI C TIMPONE R AVELLA M D DRIOLIA E | 2007 | Journal of Food Engineering2007，80，： | 1 |
| 13 | A common variant in the FTO gone is accosiated with body mass index and predisposes to childhood and adult obesity显示文摘 | Frayling T M Timpon N J Weedon M N | 2007 | Science2007，316，： | 1 |
| 14 | BK polyomavirus infection in the renal transplant recipient显示文摘 | Balba GP Javaid B Timpone JJ | 2013 | Infect Dis Clin North Am2013，27，2： | 1 |
| 15 | Six-month incidence of bloodstream infections in intestinal transplant patients显示文摘 | Akhter K Timpone J Matsumoto C | 2012 | Transpl Infect Dis2012，14，3： | 1 |
| 16 | A common variant in the FTO gene is accosiated with body mass index and predisposes to childhood and adult obesity显示文摘 | Frayling T M Timpon N J Weedon M N | | 0，，5826： | 1 |
| 17 | Radiologic case study diagnosis: atlantoaxial instability secondary to rheumatoid arthritis 显示文摘 | Timpone V Lomasney L Demos TC | 2006 | Orthopedics2006，29，11： | 1 |
| 18 | Production of dietary fiber from the edib component of citrus fruits显示文摘 | TIMPONE R D AVELLA M | 2002 | Fruit Proc2002，12，10： | 1 |
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