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| 1 | Correlation between the proportion of breast volume involved by locally advanced tumors and invasion of the skin and posterior structures显示文摘AIM: To evaluate any differences between the percentages of involved breast volume, pathologic attributes,and tumor marker expression of T3 and T4a-c tumors in locally advanced breast cancers(BC).METHODS: All patients with T3 N > 0 and T4a-c BC without evidence of distant metastasis(M0), presenting to the Breast Clinic from 1980 to 2010, were examinedto determine whether their BC's involved ≥ 50% of their breast volumes, defined by gross replacement of at least one hemisphere. Core needle biopsy or postmastectomy specimens from tumors involving a known percent of breast volume were evaluated for:(1)pathological grades and lympho-vascular invasion(LVI);(2) hormone receptor(ER/PR) expression > 0; and(3)epidermoid growth factor 2(her2) over-expression(3+)by immune-histochemical staining or fluorescent in situ hybridization.RESULTS: The data base included 98 patients with T3N> 0 M0 and 120 with T4a-c, any N disease, M0 disease. T3 tumor masses involved 50% or more of the breast in 23/98(24%), and T4a-c tumors 65/120(54%)(P < 0.001). Only 1% of T3 tumors and 23% of T4a-c tumors presented with total breast replacement. There were no significant differences between the pathological attributes and marker expression of the T3 and T4a-c tumors.CONCLUSION: These data suggest that erosion of the overlying skin or underlying chest wall by some BC may be due to neglect and delay, rather than inherent biological aggressiveness. | Parastoo B Dahi Komal P Dhiran Constantine A Axiotis Jeremy Weedon Mahmoud El-Tamer Gurinder Sidhu Albert S Braverman | 2012 | World Journal of Clinical Oncology2012，3，3： | 2 |
| 2 | Common variants inWFS1 confer risk of type 2 diabetes显示文摘 | Sandhu MS Weedon MN Fawcett KA | 2007 | Nat Genet2007，39，8： | 1 |
| 3 | Survival outcomes with the use of surgery in limited-stage small cell lung cancer:should its role be re-evaluated?显示文摘 | Schreiber D Rineer J Weedon J | 2010 | Cancer2010，116，： | 1 |
| 4 | Tube microstructure of recent and Jurassic serpulid polychaetes and the question of the Palaeozoic ' spirorbids' 显示文摘 | WEEDON M J | 1994 | Acta Palaeontologica Polonica1994，39，： | 1 |
| 5 | Trace element variation in Speleothem aragonite: Potential for palaeoenvironmental reconstruction显示文摘 | Finch A A Shaw P A Weedon G P Holmgren K | 2001 | Earth and Planetary Science Letters2001，186，： | 1 |
| 6 | Time domain inverse scattering using the local shape funetion(LSF) meth- od显示文摘 | Weedon W H Chew W C | 1993 | Inverse Problems1993，，9： | 1 |
| 7 | Maintenance treatment with long-actlng injectable risperidone in flrst-episode schizophrenia:a randomized effectiveness study显示文摘 | WEIDEN PJ SCHOOLER NR WEEDON JC | 2012 | J Clin Psychi-atry2012，73，9： | 1 |
| 8 | Statistical bias correction of global simulated daily precipitation and temperature for the application of hydrological models显示文摘 | PIANI C WEEDON G P BEST M | 2010 | J Hydrol2010，395，34： | 1 |
| 9 | Lactate levels in children with HIV/AIDS on highly active antiretroviral thetapy 显示文摘 | Desai N Mathur M Weedon J | 2003 | AIDS2003，17，10： | 1 |
| 10 | The Implicit Benefit of Learning Without Errors显示文摘 | Maxwell J P Masters R S W Kerr E Weedon E | 2001 | Quarterly Journal of Experimental Psychology2001，54，4： | 1 |
| 11 | Time-domain inverse scattering using the local shape function (LSF) method显示文摘 | Weedon WH Chew WC | 1993 | Inverse Probl1993，，9： | 1 |
| 12 | A common variant in the FTO gene is associated with body mass in- dex and predisposes to childhood and adult obesity 显示文摘 | Frayling T M Timpson N J Weedon M N | 2007 | Science2007，316，： | 1 |
| 13 | Genetic evidence that raised sex hormone binding globulin (SHBG)levels reduce the risk of type 2 diabetes 显示文摘 | Perry JR Weedon MN Langenberg C | 2010 | Hum Mol Genet2010，19，3： | 1 |
| 14 | A common va-riant in the FTO gene is associated with body mass index and predis-poses to childhood and adult obesity显示文摘 | FRAYLING TM TIMPSON NJ WEEDON MN | 2007 | Science2007，316，5826： | 1 |
| 15 | Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kit6,2(KCNJ11)and SUR1(ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes显示文摘 | Gloyn AL Weedon MN Owen KR | | 0，，02： | 1 |
| 16 | Common variants in WFS1 confer risk of type 2 diabetes显示文摘 | Sandhu MS Weedon MN Fawcett KA | | 0，，8： | 1 |
| 17 | A 3D Perfectly Matched Medium from Modified Maxwell' s Equations with Stretched Coordinates 显示文摘 | Chew W C Weedon W H | 1994 | Microwave Opt Techno Lett1994，13，7： | 1 |
| 18 | Survival outcomes with the use of surgery in hmited-stage small cell lung cancer: should its role be re-evaluated显示文摘 | Schreiber D Rineer J Weedon J | 2010 | Cancer2010，116，5： | 1 |
| 19 | Survival outcomes with the use of surgery in limited - stage small cell lung cancer:should its role be re -evaluated? 显示文摘 | Schreiber D Rineer J Weedon J | 2010 | Cancer2010，116，5： | 1 |
| 20 | 显示文摘 | Gloyn AL Weedon MN Owen KR | 2003 | Diabetes2003，52，2： | 1 |
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