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| 1 | Observation of ocean current response to 1998 Hurricane Georges in the Gulf of Mexico显示文摘The ocean current response to a hurricane on the shelf-break is examined. The study area is the DeSoto Canyon in the northeast Gulf of Mexico, and the event is the passage of 1998 Hurricane Georges with a maximum wind speed of 49 m/s. The data sets used for analy- sis consist of the mooring data taken by the Field Program of the DeSoto Canyon Eddy Intrusion Study, and simultaneous winds ob- served by NOAA (National Oceanic and Atmospheric Administration) Moored Buoy 42040. Time-depth ocean current energy density images derived from the observed data show that the ocean currents respond almost immediately to the hurricane with important differ- ences on and off the shelf. On the shelf, in the shallow water of 100 m, the disturbance penetrates rapidly downward to the bottom and forms two energy peaks, the major peak is located in the mixed layer and the secondary one in the lower layer. The response dissipates quickly after external forcing disappears. Off the shelf, in the deep water, the major disturbance energy seems to be trapped in the mixed layer with a trailing oscillation; although the disturbance signals may still be observed at the depths of 500 and 1 290 m. Verti- cal dispersion analysis reveals that the near-initial wave packet generated off the shelf consists of two modes. One is a barotropic wave mode characterized by a fast decay rate of velocity amplitude of 0.020 s-1, and the other is baroclinic wave mode characterized by a slow decay rate of 0.006 9 s-1. The band-pass-filtering and empirical function techniques are employed to the frequency analysis. The results indicate that all frequencies shift above the local inertial frequency. On the shelf, the average frequency is 1.04f in the mixed layer, close to the diagnosed frequency of the first baroclinic mode, and the average frequency increases to 1.07f in the thermocline. Off the shelf, all frequencies are a little smaller than the diagnosed frequency of the first mode. The average frequency decreases from 1.035f in the mixed layer to 1.02f in the thermocline, implying a trend for the shift in frequency of the oscillations towards f with the depth. | ZHENG Quanan LAI Ronald J HUANG Nortlen E PAN Jiayi LIU W Timothy | 2006 | Acta Oceanologica Sinica2006，25，1： | 20 |
| 2 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 3 | Interaction of obesity and inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) is a chronic inflammatory condition of unknown etiology that is thought to result from a combination of genetic, immunologic and environmental factors. The incidence of IBD has been increasing in recent decades, especially in developing and developed nations, and this is hypothesized to be in part related to the change in dietary and lifestyle factors associated with modernization. The prevalence of obesity has risen in parallel with the rise in IBD, suggesting a possible shared environmental link between these two conditions. Studies have shown that obesity impacts disease development and response to therapy in patients with IBD and other autoimmune conditions. The observation that adipose tissue produces pro-inflammatory adipokines provides a potential mechanism for the observed epidemiologic links between obesity and IBD, and this has developed into an active area of investigative inquiry. Additionally, emerging evidence highlights a role for the intestinal microbiota in the development of both obesity and IBD, representing another potential mechanistic connection between the two conditions. In this review we discuss the epidemiology of obesity and IBD, possible pathophysiologic links, and the clinical impact of obesity on IBD disease course and implications for management. | Jason W Harper Timothy L Zisman | 2016 | World Journal of Gastroenterology2016，22，35： | 6 |
| 4 | Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B显示文摘AIM:To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS:A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was performed.Patients were excluded if they had received previous treatment with another nucleoside or nucleotide analogue,were pregnant or less than 18 years old. RESULTS:Out of 336 patients,163 patients fulfilled the selection criteria.Range of follow up was 3-46 mo (mean 26 mo).134 patients(82.2%)had pre-treatment biopsies,with 26 patients(16.0%)demonstrating F3-4 fibrosis.In total,153 patients(93.9%)achieved at least Partial Virological Suppression(PVS),with 134 patients (82.2%)achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1%and 96.4%,respectively.3 patients(1.8%)failed to achieve PVS,while 5 patients(3.0%)developed virological rebound.128 patients(78.5%)maintained CVS throughout follow up.Predictors of CVS included lower baseline DNA level(P=0.001),hepatitis B virus e antigen negative status(P=0.001)and increasing age at treatment(log rank 0.001).No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION:Entecavir monotherapy is efficacious and safe in an Australian tertiary care setting.Resistance and rebound rates are very low.This is similar to data from controlled and uncontrolled trials around the world. | Farzan Fahrtash-Bahin Viraj C Kariyawasam Timothy Gray Karen Byth Jacob George Mark W Douglas | 2013 | World Journal of Gastroenterology2013，19，5： | 5 |
| 5 | The temporal price relationship between S&P 500 futures prices and the S&P 500 index显示文摘 | Kawaller Ira G Paul D Koch Timothy W Koch | 1987 | Journal of Finance1987，5，： | 2 |
| 6 | Delegated Monitors, Large and Small:Germany's Banking System, 1800- 1914 显示文摘 | Guinnane Timothy W | 2002 | Journal of Economic Literature2002，40，1： | 1 |
| 7 | Product platform design:method and application 显示文摘 | Timothy W Simpson Jonathan R A Maier Farrokh Mistree | 2001 | Engineering Design2001，13，1： | 1 |
| 8 | Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes 显示文摘 | Timothy C H Simon W D | 2011 | Diabetes Ther2011，2，3： | 1 |
| 9 | Representation of skew in time-stepped two-dimensional finite-element models of electrical machines显示文摘 | Stephen W Timothy J F Alhertus FV | 1995 | IEEE Transactions on Industry Applications1995，31，5： | 1 |
| 10 | Evolving space-filling curves to distribute radial basis functions over an inputspace显示文摘 | Timothy D C | 1994 | IEEE Transactions on Neural Networks1994，5，： | 1 |
| 11 | Influence of agr on fibrinogen binding in Staphylococcus aureus Newman显示文摘 | Christiane W Damien M Timothy J | 1996 | Infect Immun1996，64，8： | 1 |
| 12 | Effective product family design using physical programming显示文摘 | Achille Messas Michael P Martinez Timothy W Simpson | 2002 | Engineering Optimization2002，，34： | 1 |
| 13 | Biology of Influenza a Virus显示文摘 | Timothy K Cheung W Leo L | 2007 | Ann N Y Acad Sci2007，1102，： | 1 |
| 14 | Evolving space filling curves to distribute radial basis functions over an in- put space 显示文摘 | Bruce A W Timothy D C | 1994 | IEEE Transactions on Neural Net- works1994，，5： | 1 |
| 15 | A variationbased method for product family design显示文摘 | Raviraj U Nayak Wei Chen Timothy W Simpson | 2002 | Engineering Optimization2002，34，1： | 1 |
| 16 | Family caregiver burden: Results of a longitudinal study of breast cancer patients and their primary family caregivers 显示文摘 | Eva Q Dong C Timothy W | 2004 | CAMJ2004，170，12： | 1 |
| 17 | Tillage effects on soil hydraulic properties in space and time:State of the science显示文摘 | Mark W S Timothy R G James C A | 2008 | Soil and Tillage Research2008，99，1： | 1 |
| 18 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 19 | Vibrational spectra and DFT calculations of squalene显示文摘 | Hye JC Taylor W Timothy P | 2013 | Journal of MolecularStructure2013，1032，： | 1 |
| 20 | Experimental studies in the LENS supersonic and hypersonic tunnels for hypervelocity vehicle performance and code validation 显示文摘 | Michael S H Timothy P W Matthew M | 2008 | AIAA2008，2505，： | 1 |
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