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| 1 | Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research. | Clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd | 2019 | World Journal of Gastroenterology2019，25，28： | 16 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Efficient soft-output demodulation of MIMO QPSK via semidefinite re-laxation 显示文摘 | Nekuii M Kisialiou M Timothy N D | 2011 | IEEE Transactions on Signal Processing2011，5，8： | 1 |
| 4 | Trehalose biosynthesis in Rhizobium leguminosarum:trifolii and its role in desiccation tolerance显示文摘 | Helen J M Holiday D Timothy A | 2007 | Applied and Environmental Microbiology2007，73，12： | 1 |
| 5 | Retinol-binding protein 4 and insulin resistance in lean,obese,and diabetic subjects显示文摘 | Timothy E Graham M D Yang Q | 2006 | N Engl J Med2006，354，： | 1 |
| 6 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 7 | An overview of the municipal waste incineration industry in Asia and the former Soviet Union显示文摘 | TIMOTHY R CROCKETT BODE M A | 1996 | Journal of Hazardous Material1996，47，： | 1 |
| 8 | A few parts in 10^8 geodetic baseline repeatability in Gulf of California using the Global Positioning System (GPS)显示文摘 | Tralli M D and Timothy H D | 1988 | Geophys Res Lett1988，15，4： | 1 |
| 9 | Role of dendritic cells in antibody-dependent enhancement of dengue virus infection 显示文摘 | Kobpom D Bonnie M Timothy H | 2008 | Journal of virology2008，，30： | 1 |
| 10 | PI3K/Akt regulates early differentiation in human laryngeal keratinocytes 显示文摘 | Raduwan D Timothy C Bettie M | 2005 | In Vitro Cellular & Development Bio Ani2005，41，3： | 1 |
| 11 | Liquefaction Resistance using CPT and field case histories显示文摘 | TIMOTHY D STARK SCOTT M Olson | 1995 | Journal of Geotechnical Engineering1995，121，12： | 1 |
| 12 | Surface Analysis near and within the Tipton, Kansas, Tornado on 29 May 2008 显示文摘 | Lee B D Catherine A F Timothy M S | 2011 | Mon Wea Rev2011，139，： | 1 |
| 13 | Effect of temperature on the fate of genes encoding tetracycline resistance and the integrase of Class 1 integrons within anaerobic and aerobic digesters treating municipal wastewater solids显示文摘 | David L D Timothy M L | | Environment Science & Technology0，44，： | 1 |
| 14 | Morals? Who Cares About Morals? 显示文摘 | Fernando M Pinguelo Timothy D Cedrone | 2009 | Seton Hall Journal of Sports and Entertainment Law2009，，19： | 1 |
| 15 | Efficacy of difloxacin in calves experimentally infected with Mannheimia haemolytica显示文摘 | Timothy W J Olchowy D V M phD | 2000 | American Journal of Veterinary Research2000，61，6： | 1 |
| 16 | Production of germline transgenic Pacific salmonids with dramatically increased growth performance显示文摘 | Robert H D Timothy Y Y Edward M D | 1995 | Canadian Journal of Fisheries and Aquatic Sciences1995，52，7： | 1 |
| 17 | Material estimation with terahertz time-domain spectroscopy显示文摘 | TIMOTHY D D RICHARD G B DANIEL M M | 2001 | Journal of Optical Society of America A2001，18，7： | 1 |
| 18 | Laparoscopic Intraperitoneal Onlay Inguinal Herniorrhaphy显示文摘 | Vogt DM Timothy M | 1998 | Am J Surg1998，176，6： | 1 |
| 19 | Liquefaction resistance using CPT and field case histories显示文摘 | TIMOTHY D STARK M SCOTT M | 1995 | Journal of Geotechnical Engineering ASCE1995，121，12： | 1 |
| 20 | Role of cell cycle in mediating sensitivity to radiothraphy显示文摘 | PAWLIK M D KHANDAN K | 2004 | Int J Radioat Oncol Biol Phys2004，59，4： | 1 |
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