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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior显示文摘服的外皮为集成是必要的并且为大多数行为被要求的信息处理。当神经原从室的地区连续地移居联合进特定的外皮的层时,服的外皮的精致地精确的 laminar 组织在胚胎的开发期间产生。当时指南为设计神经原移植责骂的光线的神经胶质行为, pre-formed 脉管的网络为 GABAergic interneuron 移植提供支持和指导暗示。这研究提供新奇概念、机械学的卓见进 vascular-neuronal 相互作用的这个范例,揭示伽马氨基丁酸并且它经由胚胎的前脑 endothelial 房间的调停受体的发信号的新机制。与二个新 endothelial 房间的使用,特定的有条件的老鼠 GABA 小径当模特儿(Gabrb3 Tie2-Cre 和 Vgat 我们显示出的 Tie2-Cre ), 从 endothelial 房间的伽马氨基丁酸版本的那部分或完全的损失在 embryogenesis 期间导致脉管的缺点并且损害长途的移植并且外皮的 interneurons 放。使不安的 endothelial 的下游的效果导出房间的伽马氨基丁酸发信号是批评的,导致上次修改到外皮的电路和坚持的行为的赤字。而且,我们说明在支持他们血大脑障碍性质的迁居, angiogenesis 和获得的前脑 endothelial 房间发信号的伽马氨基丁酸的激活的新机制。我们的调查结果揭开并且阐明在从表明小径的古典 neuronal 伽马氨基丁酸是不同的并且在 neuropsychiatric 疾病的病原学和 pathophysiology 上打开新灯的 CNS 表明小径的新奇 endothelial 伽马氨基丁酸例如孤独性光谱混乱,癫痫,焦虑,消沉和精神分裂症。 | Suyan Li Peeyush Kumar Sampada Joshee Timo Kirschstein Sivan Subburaju Jahan S Khalili Jonas Kloepper Chuang Du Abdallah Elkhal Gabor Szabo Rakesh K Jain Rudiger Kohling Anju Vasudevan | 2018 | Cell Research2018，28，2： | 3 |
| 3 | Association of Helicobacter pylori IgA antibodies with the risk of peptic ulcer disease and gastric cancer显示文摘AIM: To compare the prevalence of Helicobacter pylori (Hpylori) IgG and IgA antibodies between adult subjects,with defined gastric diseases, nondefined gastric disorders and those representing the population.METHODS: Data on H pylori IgG and IgA antibodies,determined by enzyme immunoassay, were analyzed in 3 252 subjects with DGD including 482 patients with gastric ulcer, 882 patients with duodenal ulcer, 1 525patients with chronic gastritis only and 363 subjects with subsequent gastric cancer, 19 145 patients with NoDg and4 854 POPUL subjects. The age-adjusted prevalences were calculated for 1- and 20-year age cohorts.RESULTS: The prevalences of IgG antibodies were equally high (89-96%) in all 20-year age cohorts of the DGD groups, whereas the prevalences of IgG antibodies were lower and increased by age in the POPUL and NoDg groups. The prevalences of IgA antibodies were also higher in the DGD groups; among them CA (84-89%) and GU groups (78-91%) showed significantly higher prevalences than DU (68-77%) and CG patients (59-74%) (OR 2.49, 95%CI 1.86-3.34 between the GU and DU groups). In the CA, GU, and DU groups, the IgA prevalences showed only minor variation according to age, while they increased by age in the CG, POPUL, and NoDg groups (P≤0.0001). The IgA response, but not the IgG response, was associated with an increased risk of CA (OR 2.41, 95%CI 1.79-3.53) and GU (OR 2.57,95%CI 1.95-3.39) in comparison with CG patients.CONCLUSION: An IgA antibody response during H pylori infection is significantly more common in CA and GU patients as compared with CG patients. | Timo U Kosunen Kari Seppl Seppo Sarna Arpo Aromaa Paul Knekt Jarmo Virtamo Anniina Salomaa-Rsnen Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，43： | 3 |
| 4 | Effect of decentlation and tilt on the image quality of aspherie intraocular lens designsin amodel eye显示文摘 | Timo E Katja S | 2009 | J Cataract Refract Sur2009，35，10： | 1 |
| 5 | Application of Artificial Neural Networks in Process Fault Diagnosis显示文摘 | | 1993 | Automatica1993，29，： | 1 |
| 6 | Depression is associated with poorer outcome of lumbar spinal stenosis surgery显示文摘 | Sanna S Timo A Olavi A | 2007 | Eur Spine J2007，16，7： | 1 |
| 7 | Depression is associated with poorer outcome of lumbar spinal stenosis surgery显示文摘 | Sanna S Timo A Olavi A | 2007 | Eur Spine J2007，16，7： | 1 |
| 8 | Energy-efficient reservation-based medium access control protocol for wireless sensor networks 显示文摘 | MIKKO K JUKKA S TIMO D | 2010 | Journal of EURASIP Journal on Wireless Communications and Networking2010，57，： | 1 |
| 9 | A randomized outcome study of enteral versus intravenous nimodipine in 171 patients after acute aneurysmal subarachnoid hemorrhage显示文摘 | VILLE S PETROS N K TIMO K | 2012 | World Neurosurg2012，78，12： | 1 |
| 10 | Adenovirus type 5 early region 1B 156R protein promotes cell transformation independently of repression of p53-stimulated transcription 显示文摘 | Timo S Thomas DB | 2007 | J Virol2007，81，1： | 1 |
| 11 | 显示文摘 | Timo thy S Haddad R S Hong G J | 1999 | Polymer Preprints1999，40，1： | 1 |
| 12 | Neural Networks in Process Faulet Diagnosis显示文摘 | Timo S | 1991 | IEEE Trans Control Systems Magazine1991，21，4： | 1 |
| 13 | Robust texture classification by subsets of local binary patterns显示文摘 | Timo O Matti P Maricor S | 2000 | Pattern Recognition2000，3，： | 1 |
| 14 | Valproic acid combined with 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 in the treatment of patients with myelodysplastic syndromes 显示文摘 | Timo S Timo T Eeva J | | Haematologica0，92，8： | 1 |
| 15 | State-Space Optimization of ETL Workflows显示文摘 | Alkis S Panos V Timos S | 2005 | IEEE Transactions on Knowledge & Data Engineering2005，17，10： | 1 |
| 16 | Space aver- aging on a gas-solid drag model for numerical simula- tions of a CFB riser 显示文摘 | SRUJAL S JOUNI R TIMO H | 2012 | Powder Technology2012，218，： | 1 |
| 17 | Use of a virtual 3D software of tibial plateau fracture reconstruction显示文摘 | Eduardo MS Tobias H Timo S | 2010 | Injury2010，41，6： | 1 |
| 18 | Hierachically compressedwavelet synopses显示文摘 | Dimitris S Antonios D Timos S | 2009 | The VLDB Journal2009，18，1： | 1 |
| 19 | Absorption of N-phenylpropenoyl-L amino acids in healthy humans by oral administration of cocoa 显示文摘 | Timo S Roman L Daniela K | 2008 | Mol Nutr Food Res2008，52，： | 1 |
| 20 | Depression is associated with poorer outcome of lumbar spinal stenosis surgery显示文摘 | Sanna S Timo A Olavi A | 2007 | Eur Spine[J]2007，16，7： | 1 |
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