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| 1 | Practical Method of Updating Stochastic Remaining Life of Pipelines Using ILI Data显示文摘 | Malyukova M G Timashev S A Maltsev I L | 2004 | American Society of Mechanical Engineers2004，，： | 1 |
| 2 | On classification of metabelian Lie algebras显示文摘 | Galitski Yu L Timashev D A | 1999 | J Lie Theory1999，9，： | 1 |
| 3 | Organoids: a novel modality in disease modeling显示文摘Limitations of monolayer culture conditions have motivated scientists to explore new models that can recapitulate the architecture and function of human organs more accurately.Recent advances in the improvement of protocols have resulted in establishing three-dimensional(3D)organ-like architectures called‘organoids’that can display the characteristics of their corresponding real organs,including morphological features,functional activities,and personalized responses to specific pathogens.We discuss different organoid-based 3D models herein,which are classified based on their original germinal layer.Studies of organoids simulating the complexity of real tissues could provide novel platforms and opportunities for generating practical knowledge along with preclinical studies,including drug screening,toxicology,and molecular pathophysiology of diseases.This paper also outlines the key challenges,advantages,and prospects of current organoid systems. | Zahra Heydari Farideh Moeinvaziri Tarun Agarwal Paria Pooyan Anastasia Shpichka Tapas KMaiti Peter Timashev Hossein Baharvand Massoud Vosough | 2021 | Bio-Design and Manufacturing2021，4，4： | 1 |
| 4 | Analysis of cross-correlations in electroencephalogram signals as an approach to proactive diagnosis of schizophrenia显示文摘 | Serge F. Timashev Oleg Yu. Panischev Yuriy S. Polyakov Sergey A. Demin Alexander Ya. Kaplan | 2011 | Physica A: Statistical Mechanics and its Applications2011，，： | 1 |
| 5 | Analysis of cross-correlations in electroencephalogram signals as anapproach to proactive diagnosis of schizophrenia 显示文摘 | Timashev Serge F Panischev 0leg Yu | 2012 | Physica A2012，4，391： | 1 |
| 6 | The investigation of perfluorination sulfocation exchange membrane structure by 19F NMR relaxation and paramagnetic probe methods显示文摘 | TIMASHEV S F RUSS | 1989 | J Phys Chem1989，63，1： | 1 |
| 7 | Fluctuation Dynamics of chemiluminescence in the Maillard reaction显示文摘 | Lakeev S G Voeikov V L Timashev S F | 2011 | Russian Journal of General Chemistry2011，81，1： | 1 |
| 8 | Analysisof cross -correlations in electroencephalogram signals asan approach to proactive diagnosis of schizophrenia 显示文摘 | Timashev SF Panischev OY Polyakov YS | 2012 | Physica A : Statistical Mechanics and Its Applications2012，391，4： | 1 |
| 9 | Blood protein types and their use in select0ion显示文摘 | Timashev I Z Ostapenko V I | 1978 | Animal Breed Abst1978，，46： | 1 |
| 10 | Biofabrication of size-controlled liver microtissues incorporated with ECM-derived microparticles to prolong hepatocyte function显示文摘Multicellular microtissues of primary human hepatocytes(PHHs)co-cultured with other supporting cell types are a promis-ing model for drug screening and toxicological studies.However,these liver microtissues(LMs)rapidly lose their functions during ex vivo culture.Here,in order to mimic the cellular and structural hepatic microenvironment,we co-cultured PHHs with human mesenchymal stromal cells(MSCs)and human umbilical vein endothelial cells(HUVECs)in the presence of cell-sized microparticles(MPs)derived from liver extracellular matrix(LEMPs).The microwell culture platform enabled biofabrication of size-controlled multicellular microtissues(PHH:HUVEC:MSC=3:2:1)with efficient LEMP incorporation(about 70%at a 2:1 ratio of cells:MP).The biofabricated liver microtissues(BLMs)were cultured ex vivo for 14 days and compared to the cell-only LM in terms of gene and protein expression,functional activity,cytochrome P450(CYP450)enzyme inducibility,and drug sensitivity.The results supported superior hepatic-related gene expression,functional activity,and polarity for PHH in BLM compared to LM.CYP450 enzyme inducibility and dose-responsive sensitivity to toxic drugs were significantly higher in the BLM group.In conclusion,microtissue engineering by incorporation of tissue-specific microparticles within a multicellular microtissue can offer some advantages for drug discovery studies and cell transplantation applications.In the near future,this approach could generate a scalable platform of several functional biofabricated microtissues representing different organs. | Zahra Heydari Ibrahim Zarkesh Mohammad-Hossein Ghanian Mahdokht HAghdaei Svetlana Kotova Ensieh Zahmatkesh Zahra Farzaneh Abbas Piryaei Iman Akbarzadeh Anastasia Shpichka Roberto Gramignoli Peter Timashev Hossein Baharvand Massoud Vosough | 2021 | Bio-Design and Manufacturing2021，4，4： | 0 |
| 11 | Multilayered organic semiconductors for high performance optoelectronic stimulation of cells显示文摘The efficiency of devices for bioelectronic applications,including cell and tissue stimulation,is heavily dependent on the scale and the performance level.With miniaturization of stimulation electrodes,achieving a sufficiently high current pulse to elicit action potentials becomes an issue.Herein we report on our approach of vertically stacking organic p-n junctions to create highlyefficient multilayered organic semiconductor(MOS)photostimulation device.A tandem arrangement substantially increases the photovoltage and charge density without sacrificing lateral area,while not exceeding 200-500 nm of thickness.These devices generate 4 times higher voltages and at least double the charge densities over single p-n junction devices,which allow using lower light intensities for stimulation.MOS devices show an outstanding stability in the electrolyte that is extremely important for forthcoming in vivo experiments.Finally,we have validated MOS devices performance by photostimulating fibroblasts and neuroblasts,and found that using tandem devices leads to more effective action potential generation.As a result,we obtained up to 4 times enhanced effect in cell growth density using 3 p-n layered devices.These results corroborate the conclusion that MOS technology not only can achieve parity with state-of-the-art silicon devices,but also can exceed them in miniaturization and performance for biomedical applications. | Aleksandr Markov Alexander Gerasimenko Annie-Kermen Boromangnaeva Sofia Shashova Elena Iusupovskaia Ulyana Kurilova Vita Nikitina Irina Suetina Marina Mezentseva Mikhail Savelyev Peter Timashev Dmitry Telyshev Xing-Jie Liang | 2023 | Nano Research2023，16，4： | 0 |
| 12 | 如何做出艰难的商业决策?显示文摘中国人常常用"运筹帷幄之中,决胜千里之外"来讲做出正确的部署和决策的重要性。但是,面对棘手的商业问题,做出决策从来没那么简单。一位朋友曾经告诉我,在做决策的时候只要有51%的决策是正确的就可以了。虽然朋友的说法颇具玩笑意味,但却让我在面临艰难决策的时候颇受启发。常言道:你不做主别人就会替你做主。在Veeam,我们坚信,即使是错误的决定也好过没有决定。错误可以修正,而机会却难再有第二次。 | Ratmir Timashev | 2016 | 装备制造2016，0，5： | 0 |
| 13 | Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation显示文摘Intelligent drug delivery system based on “stimulus-response”mode emerging a promising perspective in next generation lipidbased nanoparticle.Here,we classify signal sources into physical and physiological stimulation according to their origin. | Fuxue Zhang Bozhang Xia Jiabei Sun Yufei Wang Jinjin Wang Fengfei Xu Junge Chen Mei Lu Xin Yao Peter Timashev Yuanyuan Zhang Meiwan Chen Jing Che Fangzhou Li Xing-Jie Liang | 2023 | Research2023，，2： | 0 |
| 14 | 纳米技术在局部麻醉药物缓释和光响应控释中的应用显示文摘局部麻醉药物常用于手术中暂时性阻断患者的部分神经传导功能,产生麻醉作用,或在创伤后有针对性地对部分组织进行镇痛。相比于全身麻醉药,局部麻醉药对生理状况影响较小,既能保持患者神志清醒,又能减轻疼痛,然而其临床应用仍受系统毒性、局部组织毒性、作用时间、穿透性不足等方面的局限。纳米技术能帮助其穿透生理屏障,延长神经阻滞时间,降低毒副作用。此外,通过构建光响应释放体系,局部麻醉药物制剂能实现按需释放,提升了药物效果和安全性。然而,光响应释放体系也存在生产成本高、批次间均一性差、组织穿透性低等不足,应用仍然受限。本综述根据目前研究进展,对主要的几种剂型进行介绍和分析,希望能为局部麻醉药物的响应性释放提供新的思路。 | 王祉琪 Peter Timashev 梁兴杰 栾永 | 2023 | 药学学报2023，58，3： | 0 |
| 15 | The IL13α 2R paves the way for anti-glioma nanotherapy显示文摘Glioblastoma(GBM)is one of the most aggressive(grade IV)gliomas characterized by a high rate of recurrence,resistance to therapy and a grim survival prognosis.The long-awaited improvement in GBM patients'survival rates essentially depends on advances in the development of new therapeutic approaches.Recent preclinical studies show that nanoscale materials could greatly contribute to the improvement of diagnosis and management of brain cancers.In the current review,we will discuss how specific features of glioma pathobiology can be employed for designing efficient targeting approaches.Moreover,we willsummarize the main evidence for the potential of the IL-13R alpha 2 receptor(IL13α2R)targeting in GBM early diagnosis and experimental therapy. | Ilya V.Ulasov Anton Borovjagin Anastasia Laevskaya Margarita Kamynina Peter Timashev Laura Cerchia Elena A.Rozhkova | 2023 | Genes & Diseases2023，10，1： | 0 |
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