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| 1 | Is the severity of gastroesophageal reflux dependent on hiatus hernia size?显示文摘AIM: To determine if the severity of gastroesophageal reflux disease is dependent on the size of a hiatus hernia. METHODS: Seventy-five patients with either a small(n = 25), medium(n = 25) or large(n = 25) hiatus hernia(assessed by high resolution esophageal manometry) were investigated using 24-h esophageal monitoring and a self-assessed symptom questionnaire. The questionnaire comprised the following items, each graded from 0 to 3 according to severity: heartburn; pharyngeal burning sensation; acid regurgitation; and chest pain. RESULTS: The percentage total reflux time was significantly longer in the group with hernia of 5 cm or more compared with the group with a hernia of < 3 cm(P < 0.002), and the group with a hernia of 3 to < 5 cm(P < 0.04). Pharyngeal burning sensation, heartburn and acid regurgitation were more common with large hernias than small hernias, but the frequency of chest pain was similar in all three hernia groups. CONCLUSION: Patients with a large hiatus hernia are more prone to have pathological gastroesophageal reflux and to have more acid symptoms than patients with a small hiatus hernia. However, it is unlikely that patients with an absence of acid symptoms will have pathological reflux regardless of hernia size. | Thomas Franzén Lita Tibbling | 2014 | World Journal of Gastroenterology2014，20，6： | 14 |
| 2 | Non-invasive investigation of inflammatory bowel disease显示文摘The assessment of inflammatory activity in intestinal disease in man can be done using a variety of different techniques. These range from the use of non - invasive acute phase inflammatory markers measured in plasma such as C reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) (both of which give an indirect assessment of disease activity) to the direct assessment of disease activity by intestinal biopsy performed during endoscopy in association with endoscopic scoring systems. Both radiology and endoscopy are conventional for the diagnosis of inflammatory bowel disease (IBD).However these techniques have severe limitations when it comes to assessing functional components of the disease such as activity and prognosis. Here we briefly review the value of two emerging intestinal function tests. Intestinal permeability, although ideally suited for diagnostic screening for small bowel Crohns disease, appears to give reliable predictive data for imminent relapse of small bowel Crohns disease and it can be used to assess responses to treatment. More significantly it is now clear that single stool assay of neutrophil specific proteins (calprotectin, lactoferrin) give the same quantitative data on intestinal inflammation as the 4 - day faecal excretion of 111lndium labelled white cells. Faecal calprotectin is shown to be increased in over 95% of patients with IBD and correlates with clinical disease activity. It reliably differentiates between patients with IBD and irritable bowel syndrome. More importantly, at a given faecal calprotectin concentration in patients with quiescent IBD,the test has a specificity and sensitivity in excess of 85% in predicting clinical relapse of disease. This suggests that relapse of IBD is closely related to the degree of intestinal inflammation and suggests that targeted treatment at an asymptomatic stage of the disease may be indicated. | JA Tibble IBjarnason | 2001 | World Journal of Gastroenterology2001，7，4： | 10 |
| 3 | Diagnostic accuracy and clinical application of faecal calprotectin in adult patients presenting with gastrointestinal symptoms in primary care显示文摘 | Polychronis Pavlidis Fergus JQ Chedgy Jeremy A Tibble | 2013 | Scandinavian Journal of Gastroenterology2013，，9： | 2 |
| 4 | Principles of albumin and IgG analysis in neurological disorders of reference values 显示文摘 | Tibbling G Link H | 1977 | Scand J Lab Invest1977，37，5： | 1 |
| 5 | Nitrogenase activity in marine sediments from a temperate salt marsh lagoon:modulation by complex polysaccharides,ammonium and oxygen显示文摘 | Tibbles B J Lucas MI Coyne VE | | 0，，01： | 1 |
| 6 | Intestinal permeability and inflammation in patients on NSAIDs显示文摘 | Sigthorsson G Tibble J Hayllar J | 1998 | Gut1998，43，： | 1 |
| 7 | SYK and LYN mediate Bcell receptorindependent calciuminduced apoptosis in DT40 lymphoma Bcells显示文摘 | Zhu D Tibbles H Vassilev A | 2002 | Leuk Lymphoma2002，43，： | 1 |
| 8 | A comparative study of the effects of retinoic acid given during the critical period for inducing spina bifida in mice and hamsters显示文摘 | Tibbles L Wiley MJ | 1988 | Teratology1988，37，2： | 1 |
| 9 | 显示文摘 | Hagg MK Tibbling LL Effects on facial dysfunction and swallowing capaclty of intraoral stimulation early and late after stroke | 2015 | Neu- roRehabilitation2015，36，1： | 1 |
| 10 | Trauma in pregnancy 显示文摘 | Cusick SS Tibbles CD | 2007 | Emerg Med Clin North Am2007，25，3： | 1 |
| 11 | The stress-activated protein kinase pathways 显示文摘 | Tibbles L A Woodgett J R | 1999 | CMLS1999，55，10： | 1 |
| 12 | Principles of albumin and IgG analysis in neurological disorders of reference values显示文摘 | Tibbling G Link H | 1997 | Scand J Lab Invest1997，37，5： | 1 |
| 13 | Analysis of micro - scale EDM process 显示文摘 | Katz Z Tibbles C J | 2004 | Int J Manuf Technol2004，23，5： | 1 |
| 14 | Hyperbaric-oxygen therapy显示文摘 | Tibbles PM Edelsberg JS | | 0，，： | 1 |
| 15 | Principles of albumin and IgG analysis in neurological disorders of reference values显示文摘 | Tibbling G Link H | 1997 | Scand J Lab Invest1997，37，5： | 1 |
| 16 | The stress-activated protein kinase pathways显示文摘 | TIBBLES L A WOODGETT J R | 1999 | Cell Mot Life Sci1999，55，10： | 1 |
| 17 | Trauma in pregnancy 显示文摘 | Cusick SS Tibbles CD | 2007 | Emerg Med Clin North Am2007，25，3： | 1 |
| 18 | Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10显示文摘 | Tibbles LA Spurrell JCL Bowen GP | 2002 | J Virol2002，，4： | 1 |
| 19 | Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease显示文摘 | Tibble J Sigthorsson G Foster R | 2002 | Gastroenterology2002，123，： | 1 |
| 20 | A comparative study of the effects of retinoic acid given during the critical period for inducing spina bi- fida in mice and hamsters 显示文摘 | Tibbles L Wiley MJ | 1988 | Teratology1988，37，2： | 1 |
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