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| 1 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 2 | Coal and coal byproducts:A large and developable unconventional resource for critical materials—Rare earth elements显示文摘Rare earth elements(REEs) are critical materials and provide significant values to national security,energy production, environmental protection and economic growth. The supply of REEs in U.S. solely relies on import as domestic production of REEs was ceased because of the environmental concerns during mining and lack of competitiveness. Nonetheless, unconventional REEs-containing resources,including produced water. acid mine drainage, and coal and coal byproducts(C&CBs) contain significant amounts of REEs. However, the concentrations of REEs in these resources are several orders of magnitude lower than that of REEs ores. Thus, extraction of REEs from these materials is challenging. Here we report REEs extraction with environmentally friendly method that successfully concentrated REEs from312 ppm in fly ash to 99.4% in the final product. Especially, the five critically important REEs(Dy, Eu, Nd.Tb. and Y) account for up to ~63% of the total weight of all REEs in the final 99.4%-purity product. Coal fly ash is one of the major solid coal utilization byproducts, representing great potential resources for REEs extraction. Extraction of REEs from these unconventional resources could be the way to secure domestic supply of these critical materials. | Zaixing Huang Maohong Fan Hanjing Tiand | 2018 | Journal of Rare Earths2018，36，4： | 11 |
| 3 | Dietary seaweed-derived polysaccharides improve growth performance of weaned pigs through maintaining intestinal barrier function and modulating gut microbial populations显示文摘Background:Seaweed-derived polysaccharides(SDP)represent an attractive source of prebiotic nutraceuticals for the food and animal husbandry industry.However,the mechanism by which SDP from Enteromorpha mediates pig growth are not fully understood.This study aimed to investigate how SDP supplementation influences the growth performance and intestinal health in weaned pigs.Results:In Exp.1,240 weaned pigs were randomly assigned to four dietary treatments and fed with a basal diet or a basal diet containing 200,400 or 800 mg/kg SDP,respectively,in a 21-day trial.Pigs on the 400 or 800 mg/kg SDP-supplemented group had greater ADG and lower F/G ratio than those on the control group(P<0.05).In Exp.2,20 male weaned pigs were randomly assigned to two treatments and fed with a basal diet(CON group)or a basal diet supplemented with 400 mg/kg SDP(the optimum does from Exp.1),in a 21-day trial.Pigs fed the SDP diet had greater ADG,the concentrations of serum IL-6 and TNF-αand the activities of glutathione peroxidase,superoxide dismutase and catalase(P<0.05),and lower F/G,diarrhea rate,as well as serum D-lactate concentrations and diamine oxidase activity(P<0.05).Moreover,dietary SDP supplementation enhanced secretory immunoglobulin A content,villus height and villous height:crypt depth ratio in small intestine,as well as the lactase and maltase activities in jejunum mucosa(P<0.05).SDP supplementation elevated the mRNA levels of inflammatory responserelated genes(IL-6,TNF-α,TLR4,TLR6 and MyD88),and the mRNA and protein levels of ZO-1,claudin-1 and occludin in jejunum mucosa(P<0.05).Importantly,SDP not only increased the Lactobacillus population but also reduced the Escherichia coli population in cecum(P<0.05).Furthermore,SDP increased acetic acid and butyric acid concentrations in cecum(P<0.05).Conclusions:These results not only suggest a beneficial effect of SDP on growth performance and intestinal barrier functions,but also offer potential mechanisms behind SDP-facilitated intestinal health in weaned pigs. | Tiande Zou Jin Yang Xiaobo Guo Qin He Zirui Wang Jinming You | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 10 |
| 4 | Regional difference of annual precipitation and discharge variation over west China during the last 50 years显示文摘Using annual precipitation and discharge data measured in the past five decades,this paper analyzed the regional differences over west China in terms of climate and discharge variations,and investigated the relationship between the regional characteristics and the activities of South and East Asian sum-mer monsoon. Results revealed that the precipitation and discharge in the upper reaches of the Yellow River (Central West China) have a negative correlation with those in Xinjiang (northwest China) and the Yarlung Zangbo River (the upper reaches of the Brahmaputra Rive,southwest China) regions. The geographical patterns of precipitation and discharge variations are different over west China,i.e. the regional climate displays the alteration of dry-wet-dry or wet-dry-wet from north to south in west China. The negative correlation of annual discharges between Xinjiang and the upper reaches of the Yellow River is found statistically significant in the decadal scale,and that between the Yarlung Zangbo River and the upper reaches of the Yellow River is found active in the interannual scale. The regional char-acteristics indicate that the discharge/precipitation variations in the upper reaches of the Yellow River are dominated by the East Asian summer monsoon while their variations in Xinjiang are affected by both the west wind and East Asian summer monsoon. | DING YongJian YE BaiSheng HAN TianDing SHEN YongPing LIU ShiYin | 2007 | Science China Earth Sciences2007，50，6： | 7 |
| 5 | Changes in physical features of Glacier No. 1 of the Tianshan Mountains in response to climate change显示文摘This study analyzes the changes in glacier zones and snow composition of Glacier No.1 in the Tianshan Mountains of China since 1961,and their possible relations with climate.It is found that precipitation dominated the snow composition and that air temperature and precipitation controlled the distribution of glacier zones,but interannual change in precipitation had a relatively large effect on glacier zones and snow composition during 1963–1981 (P10) and 1963–1989 (P11).However,during 1982–2007 (P20) and 1990–2007 (P21),the air temperature rise (0.57°C/10 a for P20,0.76°C/10 a for P21) was more influential than the precipitation increase (51.3 mm/10 a for P20),and air temperature was principally responsible for the evolution of glacier zones and snow composition most probably resulting from recent climate warming. | LI XiangYing DING YongJian YE BaiSheng HAN TianDing | 2011 | Chinese Science Bulletin2011，56，26： | 6 |
| 6 | Investigation into dynamic response of regional sites to seismic waves using shaking table testing显示文摘This study addresses the changes in acceleration,pore water pressure and Fourier spectrums of different types of seismic waves with various amplitudes via large-scale shaking table tests from two sites:a sand-containing regional site and an all-clay site.Comparative analyses of the test results show that the pore water pressures in sand-soil layers of the regional site initially increase and then decrease as the amplitudes of the seismic accelerations increase.The actions of the vertical and vibrational seismic waves contribute to greater pore water pressures.The amplification coefficient of the sand-layer regional site becomes smaller as the seismic waves grow stronger,so that both sites are capable of filtering high frequencies and amplifying low frequencies of seismic waves.This is more apparent with the increase in the peak value of the acceleration,and the natural vibration frequencies of both sites decrease with the transmission of the seismic waves from the basement to the ground surface.The decreasing frequency value of the sand-containing regional site is smaller than that of the all-clay site. | Li Yadong Cui Jie Guan Tianding Jing Liping | 2015 | Earthquake Engineering and Engineering Vibration2015，14，3： | 3 |
| 7 | The surface velocity feature of Glacier No.1 at the headwater of Urumqi River,Tianshan Mountain显示文摘The movement of a glacier can redistribute glacier mass balance and change water and thermal conditions of the glacier.Thus,the glacier can maintain its dynamic balance.Surface velocity of a glacier is a basic feature of glacier movement.With successive monthly observations from 2006 to 2008,we obtained spatial and temporal variations for surface velocity of Glacier No.1 at the headwater of Urumqi River,Tianshan Mountain.Dynamic simulation was used to verify the findings.Results show that altitudinal distribution of glacier velocity was influenced by synthetic effects such as glacier thickness,slope,and bedrock morphology.However,seasonal variation was influenced by changing glacier thickness. | ZaiMing Zhou ZheFan Jing ShuHui Zhao TianDing Han ZhongQin Li | 2009 | Research in Cold and Arid Regions2009，1，6： | 3 |
| 8 | Hydrological effects of alpine permafrost in the headwaters of the Urumqi River,Tianshan Mountains显示文摘Against the background of climate change, alpine permafrost active layers have shown a gradual thickening trend and the hydrothermal conditions have undergone significant changes in the Tianshan Mountains and the Qinghai-Tibet Plateau, China. At the ice-free cirque basins in the headwaters of the Urumqi River(hereafter referred to as the Ice-Free Cirque) in eastern Tianshan, China, the hydrological effects of the alpine permafrost active layers appear to have also exhibited significant changes recently. The increasing trend of local precipitation is clear in May and June. The onset of winter and spring snowmelt runoff clearly lags behind increases of air temperature, and the runoff peak appears near the beginning of the melting season, which results in the spring runoff increasing. In summer, runoff decreases strongly and the maximum runoff occurs earlier. In our analysis of meteorological and hydrologic data from 1959 to 2010, the runoff and precipitation changes are significantly correlated. In the initial stage of runoff, the runoff-producing process is mainly under the control of the soil water content and soil temperature in the 0–30 cm active layers. Spring precipitation and snowmelt water are mainly involved in the processes of infiltration and evaporation while some melt water infiltrates into the seasonal thawed layer and stays above the frozen layers. During the strong ablation period in summer, the runoff-generating process is mainly controlled by soil water content in the active layers deeper than 60 cm. In the active layer, precipitation and seasonal snowmelt water infiltrates, migrates, collects, and then forms runoff. | TianDing Han HongZheng Pu Peng Cheng KeQin Jiao | 2016 | Research in Cold and Arid Regions2016，8，3： | 3 |
| 9 | Global and local information combined to detect singular points in fingerprint images显示文摘An algorithm is proposed,which combines global and local information of fingerprint images to detect singular points.It's mathematically proven that normal lines of gradient of double orientation field(GDOF) pass through singular points.Normal lines of GDOF use rather global information to detect candidate singular points.Fingerprint image is divided into blocks and normal lines of GDOF are drawn.The number of normal lines that pass through each block is accumulated.The block that has the maximum number corresponds to a candidate singular point.It can be seen as a kind of Hough transform(HT).As candidate singular points detected by global information may have a little warp from their real positions,it's necessary to use local information to refine their positions.Poincare index is chosen,and uses local information to refine the candidate singular points.This makes our algorithm more robust to noise than methods that only use local information.What's more,the pairs of the detected singular points are used to classify fingerprint.Experimental results show that our algorithm performs well and fast enough for real time application in databases NIST-4. | FAN LingLing WANG ShuGuang GUO TianDe | 2013 | Science China(Information Sciences)2013，56，6： | 2 |
| 10 | Temporal properties of pattern adaptation of relay cells in the lateral geniculate nucleus of cats显示文摘The temporal properties of pattern adaptation of relay cells induced by repeated sinusoidal drifting grating were investigated in the dorsal lateral geniculate nucleus (dLGN) of cats. The results showed that the response amplitude declined and the response latency prolonged when relay cells were pattern-adapted in dLGN, like the similar findings in visual cortex. However, in contrast to the result in cortex, the response phase of relay cells advanced. This implies that an inhibition with relatively long latency may participate in the pattern adaptation of dLGN cells and the adaptation in dLGN may be via a mechanism different from that of visual cortex. | YANG Yupeng JIN Jianzhong ZHOU Yifeng SHOU Tiande | 2001 | Chinese Science Bulletin2001，46，17： | 2 |
| 11 | The periodic wave solutions and solitary wave solutions for a class of nonlinear partial differential cquations显示文摘 | ZHOU Yubin WANG Mingliang MIAO Tiande | 2004 | Physics Letters A2004，323，12： | 1 |
| 12 | Invasive neuroendocrine carcinoma of the breast显示文摘 | BingWei TianDing YanXing WeiWei ZhenTian FengTang SusanAbraham KhaziNayeemuddin KellyHunt YunWu | 2010 | Cancer2010，，19： | 1 |
| 13 | B-Spline-Based Curve Fitting to Cam Pitch Curve Using Reinforcement Learning显示文摘Directly applying the B-spline interpolation function to process plate cams in a computer numerical control(CNC)system may produce verbose tool-path codes and unsmooth trajectories.This paper is devoted to addressing the problem of B-splinefitting for cam pitch curves.Considering that the B-spline curve needs to meet the motion law of the follower to approximate the pitch curve,we use the radial error to quantify the effects of thefitting B-spline curve and the pitch curve.The problem thus boils down to solving a difficult global optimization problem tofind the numbers and positions of the control points or data points of the B-spline curve such that the cumulative radial error between thefitting curve and the original curve is minimized,and this problem is attempted in this paper with a double deep Q-network(DDQN)reinforcement learning(RL)algorithm with data points traceability.Specifically,the RL envir-onment,actions set and current states set are designed to facilitate the search of the data points,along with the design of the reward function and the initialization of the neural network.The experimental results show that when the angle division value of the actions set isfixed,the proposed algorithm can maximize the number of data points of the B-spline curve,and accurately place these data points to the right positions,with the minimum average of radial errors.Our work establishes the theoretical foundation for studying splinefitting using the RL method. | Zhiwei Lin Tianding Chen Yingtao Jiang Hui Wang Shuqin Lin Ming Zhu | 2023 | Intelligent Automation & Soft Computing2023，，5： | 1 |
| 14 | Applications of the weighted scheme for GNLS equation in solving soliton solutions显示文摘 | Zhang Tiande Cao Qingjie G W Price | 1998 | The Korean Journal of Computational and Applied Mathematics1998，5，3： | 1 |
| 15 | Spatial and seasonal distribution of organochlorine pesticides in the sediments of the Yangtze Estuary显示文摘 | Yangyang Li Junfeng Niu Zhenyao Shen Chi Zhang Zhengzao Wang Tiande He | 2014 | Chemosphere2014，，： | 1 |
| 16 | Applications of the weighted scheme for GNLS equations in solving soliton solutions显示文摘 | Zhan Tiande Cao Qing Price G W | 1998 | Korean J Comput Appl Math1998，5，3： | 1 |
| 17 | The periodic wave solutions and solitary wave solutions for a class of nonlinear par- tial differential equations 显示文摘 | Zhou Yubin Wang Mingliang Miao Tiande | 2004 | Phys Lett A2004，，323： | 1 |
| 18 | Rock2 regulates Cdc25A through ubiquitin proteasome system in hepato-cellular carcinoma cells 显示文摘 | LIU Tiande YU Xin LI Guohui | 2012 | Experimental Cell Re-search2012，16，： | 1 |
| 19 | UpregulationofIL-23 expression in patients with chronic hepatitis B is mediated by the HBx/ERK/NF-κB pathway显示文摘 | XiaL TianD HuangW etal | 2012 | J Immunol2012，188，2： | 1 |
| 20 | The long noncoding RNA,Jpx,is a mo-lecular switch for X chromosome inactivation显示文摘 | TianD Sun S Lee JT ei al | 2010 | Cell2010，，3： | 1 |
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