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| 1 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 2 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 3 | Angiotensinogen g-ene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension显示文摘 | TIAGO A D SAMANI N J CANDY G P | 2002 | Circulation2002，106，12： | 1 |
| 4 | Diagnosis and management of laryngopharyngeal reflux disease显示文摘 | Pontes P Tiago R | 2006 | Curr Opin Otolaryngol Head Neck Surg2006，14，： | 1 |
| 5 | Target costing operationalization during product development:Model and application显示文摘 | Tiago P F Francisco J K N Michael R D | 2009 | Int J Production Economics2009，，118： | 1 |
| 6 | Enhanced cerebral ex- pression of MCT1 and MCT2 in a rat ischemia model occurs in ac- tivated microglial cells 显示文摘 | Tiago J M Karin P Fumihiko M | 2009 | J Cereb Blood Flow Met2009，29，50： | 1 |
| 7 | Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension 显示文摘 | Tiago A D Samani N J Candy G P | 2002 | Circulation2002，106，12： | 1 |
| 8 | Partial root zone drying:effects on growth and fruit quality of field-grown grapevines(Vitis vinifera)显示文摘 | Tiago P Carlos M L Rodrigues M L | 2003 | Functional Plant Biology2003，30，6： | 1 |
| 9 | Partial rootzone drying: effects on growth and fruit quality of field-grown grapevines显示文摘 | Tiago P Carlos D S Lopes M | 2003 | Functional Plant Biology2003，30，6： | 1 |
| 10 | Thermal characteristics analysis of an IGBT using a fiber bragg grating显示文摘 | BAZZO J P TIAGO L MARCIO V | 2012 | Optics and La- sers in Engineering2012，50，2： | 1 |
| 11 | Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension显示文摘 | TIAGO A D SAMANI N J CANDY G P | 2002 | Circulation2002，106，： | 1 |
| 12 | Association between an atrial natriuretic peptide gene polymorphism and normal blood pressure in subjects of African ancestry显示文摘 | Nkeh B Tiago A Candy G P | 2002 | Cardiovasc J S Aft2002，13，3： | 1 |
| 13 | Transvesical thoracoscopy: A natural orifice translumenal endoscopic approach for thoracic surgery显示文摘 | Estêv?o Lima Tiago Henriques-Coelho Carla Rolanda José M. Pêgo David Silva José L. Carvalho Jorge Correia-Pinto | 2007 | Surgical Endoscopy2007，，6： | 1 |
| 14 | Thermal characteristics analysis of an IGBT using a fiber brag grating 显示文摘 | BAZZO J P TIAGO L MARCIO V | 2012 | Opt Lasers Eng2012，50，2： | 1 |
| 15 | Control of stomatal aperture and carbon uptake by deficit irrigation in two grapevine cultivars显示文摘 | Claudia R de Souza Joao P Maroco Tiago P dos Santos | 2005 | Agriculture Ecosystems and Environment2005，，106： | 1 |
| 16 | Partial rootzone drying:effects on growth and fruit quality of field-grown grapevines(Vitis vinifera)显示文摘 | Tiago P dos Santos Carlos M Lopes M Lucília Rodrigues | 2003 | Functional Plant Biology2003，30，6： | 1 |
| 17 | An EFG method for the nonlinear analysis of plates undergoing arbitrarily large deformations显示文摘 | Tiago C Pimenta P M | 2008 | Engineering Analysis with Boundary Elements2008，32，49： | 1 |
| 18 | Direct-acting antivirals for chronic hepatitis C treatment: The experience of two tertiary university centers in Brazil显示文摘BACKGROUND Hepatitis C virus(HCV)treatment has undergone major changes in recent years.Previous interferon-based therapies have been replaced by oral direct-acting antivirals(DAA)regimens,with high sustained virologic response(SVR)rates,and a lower incidence of adverse events(AEs).AIM To evaluate the efficacy and safety of DAAs for HCV treatment in subjects from two tertiary university centers in Brazil.METHODS This is a multicenter retrospective cohort study of 532 patients with chronic hepatitis C(CHC),undergoing treatment with interferon-free regimens from November 2015 to November 2019.The therapeutic regimen was defined by the current Brazilian guidelines for HCV management at the time of treatment.Demographic,anthropometric,clinical,and laboratory variables were evaluated.SVRs were assessed at 12 to 24 wk after therapy by intention-to-treat(ITT),and modified ITT(m-ITT)analysis.AEs and serious adverse events(SAEs)were registered.In the statistical analysis,a P value of<0.05 was considered significant.RESULTS The mean age was 56.88 years,with 415(78.5%)being HCV genotype 1,followed by genotype 3(20.1%).Moreover,306(57.5%)subjects had cirrhosis,and a third of them had decompensated cirrhosis.Sofosbuvir(SOF)plus daclatasvir±ribavirin was the most frequently used treatment(66.9%),followed by SOF plus simeprevir(21.2%).The overall ITT SVR was 92.6%(493/532),while the m-ITT SVR was 96.8%(493/509).Variables associated with treatment failure via ITT evaluation were hepatic encephalopathy(OR:4.320;95%CI:1.920-9.721,P=0.0004),presence of esophageal varices(OR:2.381;95%CI:1.137-4.988,P=0.0215),previous portal hypertensive bleeding(OR:2.756;95%CI:1.173-6.471,P=0.02),higher model for end-stage liver disease scores(OR:1.143,95%CI:1.060–1.233,P=0.0005),lower serum albumin levels(OR:0.528,95%CI:0.322-0.867,P=0.0115),higher serum creatinine(OR:1.117,95%CI:1.056-1.312,P=0.0033),and international normalized ratio(INR)levels(OR:5.542,95%CI:2.023-15.182,P=0.0009).AEs were reported in 41.1%(211/514)of patients,and SAEs in 3.7%.The female gender,higher body mass index,esophageal varices,higher INR values,and longer treatment duration were independently associated with AE occurrence.CONCLUSION Treatment with oral DAAs attains a high SVR rate,with fewer SAEs in a real-life cohort of subjects with CHC,from two tertiary university centers in Brazil. | Mariana Sandoval Lourenço Patricia Momoyo Y Zitelli Marlone Cunha-Silva Arthur Ivan N Oliveira Cláudia P Oliveira Tiago Sevá-Pereira Flair JoséCarrilho Mario G Pessoa Daniel F Mazo | 2022 | World Journal of Hepatology2022，14，1： | 1 |
| 19 | Partial rootzone drying: effects on growth and fruit quality of field - grown grapevines ( Vitis vinifera) 显示文摘 | TIAGO P DOS SANTOS | 2003 | Functional Plant Biology2003，30，6： | 1 |
| 20 | Thermal characteristics analysis of an IGBT using a fiber bragg grating 显示文摘 | BAZZO J P TIAGO L MARCIO V | 2012 | Optics and Lasers in Engineering2012，50，2： | 1 |
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