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| 1 | Upper gastrointestinal bleeding risk scores: Who, when andwhy?显示文摘Upper gastrointestinal bleeding(UGIB) remains a significant cause of hospital admission. In order to stratify patients according to the risk of the compli-cations, such as rebleeding or death, and to predict the need of clinical intervention, several risk scores have been proposed and their use consistently recommended by international guidelines. The use of risk scoring systems in early assessment of patients suffering from UGIB may be useful to distinguish high-risks patients, who may need clinical intervention and hospitalization, from low risk patients with a lower chance of developing complications, in which management as outpatients can be considered. Although several scores have been published and validated for predicting different outcomes, the most frequently cited ones are the Rockall score and the Glasgow Blatchford score(GBS). While Rockall score, which incorporates clinical and endoscopic variables, has been validated to predict mortality, the GBS, which is based on clinical and laboratorial parameters, has been studied to predict the need of clinical intervention. Despite the advantages previously reported, their use in clinical decisions is still limited. This review describes the different risk scores used in the UGIB setting, highlights the most important research, explains why and when their use may be helpful, reflects on the problems that remain unresolved and guides future research with practical impact. | Sara Monteiro Tiago Cúrdia Gonçalves Joana Magalhães JoséCotter | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 5 |
| 2 | Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil显示文摘AIM To identify environmental risk factors associated with the development of Crohn's disease(CD) in order to reassess the hygiene hypothesis.METHODS A hospital-based, case-control study was carried out with CD patients(n = 145) and controls(n = 163)representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water(P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender(OR = 2.09), under age 40(OR = 3.10), white(OR = 2.32), from a small family in childhood(OR = 2.34) and adulthood(OR = 3.02), absence of viral infections in childhood(OR = 2.23), exposure to enteric pathogens(OR = 2.41), having had an appendectomy(OR = 2.47) and prior or current smoker(OR = 2.83/1.12). CONCLUSION Most variables supporting the 'hygiene hypothesis' are associated with the development of CD but are not independent predictors of the diagnosis. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 3 | Pseudomelanosis duodeni associated with chronic renal failure显示文摘Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different drugs.We report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin index.Gastroduodenal endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the moment.In addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological study.Even though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined. | Marcia Henriques de Magalhes Costa Maria da Gloria Fernandes Pegado Cleber Vargas Maria Elizabeth C Castro Kalil Madi Tiago Nunes Cyrla Zaltman | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 4 | Study of Ball Bearing Torque under Elastohydrodynamic Lubrication 显示文摘 | Tiago C Beatriz G Armando C | 2011 | TribologyInternational2011，44，： | 1 |
| 5 | Growth and proteolytic activity of hairy roots from Centaurea calcitrapa-effect of nitrogen and sucrose显示文摘 | Pedro M L L Susana de C Tiago M M | 2002 | Enzyme and Microbial Technology2002，31，3： | 1 |
| 6 | Friction torque in grease lubricated thrust ball bearings 显示文摘 | Tiago C Beatriz G Armando C | 2011 | Tribology In- ternational2011，44，： | 1 |
| 7 | Growth and proteolytic activity of hairy roots from Centaurea calcitrapa: effect of nitrogen and sucrose 显示文摘 | Pedro M L L Susana D C Tiago M M | 2002 | Enzyme Microb Technol2002，31，： | 1 |
| 8 | Scanning electron microscopy and microbiological evaluation of equine burn wound repair after platelet-rich plasma gel treatment显示文摘 | Maciel F B De Rossi R Tiago J C Modolo | 2012 | Burns:Journal of the International Society for Burn Injuries2012，38，7： | 1 |
| 9 | Peroxynitrite induces F-actin depolymerization and blockade of myosin ATPase stimulation 显示文摘 | Tiago T Ramos S Aureliano M Gutierrez-Merino C | 2006 | BBRC2006，342，1： | 1 |
| 10 | Faulting of salt-withdrawing basins during early halokinesis: Effects on the Paleogene Rio Doce Can- yon system (Espirto Santo Basin, Brazil) 显示文摘 | Tiago M A Joe C Richard J D | 2009 | AAPG Bulletin2009，93，5： | 1 |
| 11 | Lactobacillus paracasei isolated from grape sourdough:acid,bile,salt,and heat tolerance after spray drying with skim milk and cheese whey显示文摘 | EUNICE C I TIAGO S JULIANAU G L | 2015 | European Food Research Technology2015，240，： | 1 |
| 12 | Evaluation and treatment of pediatric ADHD显示文摘 | Denisco S Tiago C Kravitz C | 2005 | Nurse Pract2005，30，8： | 1 |
| 13 | Faulting of salt-withdra-wing basins during early halokinesis:Effects on the Paleogene Rio Doce Canyon system (Espirto Santo Basin,Brazil)显示文摘 | Tiago M A Joe C Richard J D | | 0，，05： | 1 |
| 14 | An EFG method for the nonlinear analysis of plates undergoing arbitrarily large deformations显示文摘 | Tiago C Pimenta P M | 2008 | Engineering Analysis with Boundary Elements2008，32，49： | 1 |
| 15 | Exercise trainingprevents the microvascular rarefaction in hypertension balancingangiogenic and apoptotic factors role of microRNAs 16, 21,and 126 显示文摘 | Tiago Fernandes Flavio C Magalhaes | 2012 | Hypertension2012，59，2： | 1 |
| 16 | Is It Possible to Predict the Presence of Intestinal Angioectasias?显示文摘 | Tiago Cúrdia Gon?alves Joana Magalh?es Pedro Boal Carvalho Maria Jo?o Moreira Bruno Rosa José Cotter Spiros D. Ladas | 2014 | Diagnostic and Therapeutic Endoscopy2014，，： | 1 |
| 17 | Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil显示文摘BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be multifactorial.The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases.AIM To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development indices.METHODS A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was applied.Logistic regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),respectively.CONCLUSION This is the first examining environmental exposures as risk factors for inflammatory bowel disease in Brazil.Most of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman | 2020 | World Journal of Gastroenterology2020，26，25： | 1 |
| 18 | Server consolida?tion with migration control for virtualized data centers显示文摘 | TIAGO C F MARCO AS N RODRIGO N C | 2011 | Future Gen?eration Comp Syst2011，27，8： | 1 |
| 19 | Growth and proteolytic activity of hairy roots from Centaurea calcitrapa: effect of nitrogen and sucrose 显示文摘 | PEDRO M L LOURENCO S C TIAGO M M | 2002 | Enzyme and Microbial Technology2002，31，3： | 1 |
| 20 | Exercise Training Prevents the Microvascular rarefaction in Hypertension balancing Angiogenic and Apeptotic Factors Role of MicroRNAs - 16, - 21, and - 126显示文摘 | Tiago Femandes Flavio C Magalhaes | 2012 | Hypertension2012，59，2： | 1 |
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