|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Radiation Exposure from Diagnostic Imaging Studies Among Patients with Inflammatory Bowel Disease in a Safety-Net Health-Care System显示文摘 | Jason K. Hou Hoda M. Malaty Selvi Thirumurthi | 2014 | Digestive Diseases and Sciences2014，，： | 1 |
| 2 | Complete mucostatic impression: A new attempt显示文摘 | Bindhoo YA Thirumurthy VR Kurien A | 2012 | J Pro- sthodont2012，21，3： | 1 |
| 3 | Comparative Evaluation of Topical versus Intrastromal Voriconazole as an Adjunct to Natamycin in Recalcitrant Fungal Keratitis显示文摘 | Namrata Sharma Jacob Chacko Thirumurthy Velpandian Jeewan S. Titiyal Rajesh Sinha Gita Satpathy Radhika Tandon Rasik B. Vajpayee | 2012 | Ophthalmology2012，，： | 1 |
| 4 | Reaction Cross Sections in Si of Light Proton-Halo Can-didates 12Nand 17Ne显示文摘 | WARNER R E THIRUMURTHY H WOODROFFE J | 1998 | Nucl Phys1998，635，： | 1 |
| 5 | Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders显示文摘 | Pop-Eleches C Thirumurthy H Habyarimana JP | 2011 | AIDS2011，25，6： | 1 |
| 6 | Does deep sedation with propofol affect adenoma detection rates in average risk screening colonoscopy exams?显示文摘AIM To determine the effect of sedation with propofol on adenoma detection rate(ADR) and cecal intubation rates(CIR) in average risk screening colonoscopies compared to moderate sedation.METHODS We conducted a retrospective chart review of 2604 firsttime average risk screening colonoscopies performed at MD Anderson Cancer Center from 2010-2013. ADR and CIR were calculated in each sedation group. Multivariable regression analysis was performed to adjust for potential confounders of age and body mass index(BMI). RESULTS One-third of the exams were done with propofol(n = 874). Overall ADR in the propofol group was significantly higher than moderate sedation(46.3% vs 41.2%, P = 0.01). After adjustment for age and BMI differences, ADR was similar between the groups. CIR was 99% for all exams. The mean cecal insertion time was shorter among propofol patients(6.9 min vs 8.2 min; P < 0.0001).CONCLUSION Deep sedation with propofol for screening colonoscopy did not significantly improve ADR or CIR in our population of average risk patients. While propofol may allow for safer sedation in certain patients(e.g., with sleep apnea), the overall effect on colonoscopy quality metrics is not significant. Given its increased cost, propofol should be used judiciously and without the implicit expectation of a higher quality screening exam. | Selvi Thirumurthi Gottumukkala S Raju Mala Pande Joseph Ruiz Richard Carlson Katherine B Hagan Jeffrey H Lee William A Ross | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 1 |
| 7 | Development and validation of a simple liquid chromatogra-phic method with ultraviolet detection for the determination of imatinib in biological samples显示文摘 | Thirumurthy Velpandian Rajani Mathur Nitin K Agarwal | 2004 | Journal of Chromatography B2004，804，2： | 1 |
| 8 | Helicobacter pylori infection in India from a western perspective显示文摘 | Thirumurthi S Graham DY | 2012 | Indian J Med Res2012，136，4： | 1 |
| 9 | MDM2-mediated degradation of SIRT6 pbospborylated by AKTI promotes tumorigenesis and lrasluzumab resistance in breast cancer显示文摘 | Thirumurthi U Sben J Xia W | 2014 | Sci Signal2014，7，336： | 1 |
| 10 | MDM2-mediated degradationof SIRT6 phosphorylated by AKT1 promotes tumorigenesisand trastuzumab resistance in breast cancer显示文摘 | Thirumurthi U Shen J Xia W | 2014 | Sciencesignaling2014，7，336： | 1 |
| 11 | Binding site analysis of CCR2 through in silico methodologies: docking, CoMFA, and CoMSIA 显示文摘 | GUGAN K CHANGDEV G G THIRUMURTHY M | 2011 | Chem Biol Drug Des2011，78，1： | 1 |
| 12 | How to deal with large colorectal polyps: snare, endoscopic mucosal resection, and endoscopic submucosal dissection; resect or refer?显示文摘 | Selvi Thirumurthi Gottumukkala S. Raju | 2016 | Current Opinion in Gastroenterology2016，，： | 1 |
| 13 | Ocular manifestations of central insulin resistance显示文摘Central insulin resistance, the diminished cellular sensitivity to insulin in the brain, has been implicated in diabetes mellitus, Alzheimer’s disease and other neurological disorders. However, whether and how central insulin resistance plays a role in the eye remains unclear. Here, we performed intracerebroventricular injection of S961, a potent and specific blocker of insulin receptor in adult Wistar rats to test if central insulin resistance leads to pathological changes in ocular structures. 80 mg of S961 was stereotaxically injected into the lateral ventricle of the experimental group twice at 7 days apart, whereas buffer solution was injected to the sham control group. Blood samples, intraocular pressure, trabecular meshwork morphology, ciliary body markers, retinal and optic nerve integrity, and whole genome expression patterns were then evaluated. While neither blood glucose nor serum insulin level was significantly altered in the experimental or control group, we found that injection of S961 but not buffer solution significantly increased intraocular pressure at 14 and 24 days after first injection, along with reduced porosity and aquaporin 4 expression in the trabecular meshwork, and increased tumor necrosis factor α and aquaporin 4 expression in the ciliary body. In the retina, cell density and insulin receptor expression decreased in the retinal ganglion cell layer upon S961 injection. Fundus photography revealed peripapillary atrophy with vascular dysregulation in the experimental group. These retinal changes were accompanied by upregulation of pro-inflammatory and pro-apoptotic genes, downregulation of anti-inflammatory, anti-apoptotic, and neurotrophic genes, as well as dysregulation of genes involved in insulin signaling. Optic nerve histology indicated microglial activation and changes in the expression of glial fibrillary acidic protein, tumor necrosis factor α, and aquaporin 4. Molecular pathway architecture of the retina revealed the three most significant pathways involved being inflammation/cell stress, insulin signaling, and extracellular matrix regulation relevant to neurodegeneration. There was also a multimodal crosstalk between insulin signaling derangement and inflammation-related genes. Taken together, our results indicate that blocking insulin receptor signaling in the central nervous system can lead to trabecular meshwork and ciliary body dysfunction, intraocular pressure elevation, as well as inflammation, glial activation, and apoptosis in the retina and optic nerve. Given that central insulin resistance my lead to neurodegenerative phenotype in the visual system, targeting insulin signaling may hold promise for vision disorders involving the retina and optic nerve. | Muneeb A.Faiq Trina Sengupta Madhu Nath Thirumurthy Velpandian Daman Saluja Rima Dada Tanuj Dada Kevin C.Chan | 2023 | Neural Regeneration Research2023，18，5： | 0 |
| 14 | 向HIV感染高危女性分发自我检测工具对男性性伴接受HIV检测和采取安全性行为的影响显示文摘在撒哈拉以南非洲地区促进男性接受HIV检测是进行综合预防的基础。HIV自我检测已被证明具有较高的可接受性,但对于如何分发自我检测工具尚缺少最佳策略。肯尼亚在Kisumu的两个机构开展了一项队列研究,招募18.39岁的HIV阴性女性来为男性性伴分发唾液HIV快速自我检测工具,一个机构为产前及产后护理门诊,另一个机构为女性性工作者随访点。 | Thirumurthy H Masters SH Mavedzenge SN 薛辉 | 2016 | 中华预防医学杂志2016，50，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员